- Technique for preparing erythrosin B
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The invention discloses a technique for preparing erythrosin B. The technique comprises the steps of 1, making fluorescein which serves as the start material react with iodate to generate erythrosine under the action of a solvent and a catalyst; 2, making the erythrosine prepared in step 1 react with alkali to generate the erythrosine B under the action of a solvent. The technique has the advantages that operation is easy, cost is low, yield is high, pollution is light, and iodine utilization rate is high. The technique is suitable for industrial production and is suitable for production of most relevant enterprises.
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Paragraph 0048; 0051; 0052; 0053; 0054
(2017/04/19)
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- Single label comparative hybridization
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The present invention provides methods of detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, the present invention provides advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples. Moreover, invention methods are also useful for the detection or diagnosis of de novo genetic aberrations associated with post-natal developmental abnormalities.
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