16474-43-4

Basic information

• Product Name: tert-Butyl trimethylacetate
• Synonyms: tert-Butyl trimethylacetatetert-Butyl pivalate;tert-Butyl trimethyl;Propanoic acid, 2,2-dimethyl, 1,1-dimethylethyl ester;T-BUTYL PIVALATE;TERT-BUTYL TRIMETHYLACETATE;TERT-BUTYL PIVALATE;tert-Butyl trimethylacetate,98%
• CAS NO: 16474-43-4
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.24
• Mol File: 16474-43-4.mol

Chemical Properties

• Boiling Point: 134-135 °C
• Flash Point: >62°(144°F)
• Appearance: Clear colorless/Liquid, Darkening During Storage
• Density: 0.813
• Vapor Pressure: 5.65mmHg at 25°C
• Refractive Index: 1.391-1.393
• CAS DataBase Reference: tert-Butyl trimethylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl trimethylacetate(16474-43-4)
• EPA Substance Registry System: tert-Butyl trimethylacetate(16474-43-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 16474-43-4(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
Tert-Butyl trimethylacetate is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to serve as a building block in the development of new medications, contributing to the advancement of pharmaceutical research and drug discovery.
2. Used in Chemical Synthesis:
In the field of organic chemistry, tert-Butyl trimethylacetate can be utilized as a reagent in various chemical reactions. Its ester group can participate in a range of reactions, such as hydrolysis, transesterification, and nucleophilic acyl substitution, making it a versatile compound for the synthesis of different organic molecules.
3. Used in Solvent Applications:
Tert-Butyl trimethylacetate, due to its solubility properties, can be employed as a solvent in various industrial processes. Its ability to dissolve a wide range of substances makes it suitable for use in the production of paints, coatings, and adhesives, as well as in the purification and separation of certain chemicals.
4. Used in Flavor and Fragrance Industry:
Tert-Butyl trimethylacetate may also find applications in the flavor and fragrance industry. Its unique odor and taste profile can be harnessed to create new and distinct scents for use in the production of perfumes, colognes, and other fragrance products.

Synthesis Reference(s)

Journal of the American Chemical Society, 99, p. 6756, 1977 DOI: 10.1021/ja00462a049

InChI:InChI=1/C9H18O2/c1-8(2,3)7(10)11-9(4,5)6/h1-6H3

Upstream product

• 677-22-5 tert-butylmagnesium chloride 
• 3282-30-2 pivaloyl chloride 
• 75-98-9 Trimethylacetic acid 
• 4195-19-1 pivaloyl imidazole 
• 75-65-0 tert-butyl alcohol 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 28058-96-0 S-tert-butyl 2,2-dimethyl-thiopropanoate 
• 540-88-5 acetic acid tert-butyl ester 
• 598-98-1 Methyl pivalate 
• 243990-73-0 2,2-dimethyl-propionic acid 1-(2,5-dichloro-phenyl)-2,2-bis-methylsulfanyl-vinyl ester 
• 497265-64-2 N-tert-butoxy-N-chloro-2,2-dimethylpropanamide 
• 106129-11-7 tert-butyl 2,2-dimethylpropanohydroxamate 
• 5176-27-2 N-tert-butyloxycarbonyl-pyrrole 

Downstream Products

• 91873-86-8 3,3-Dimethyl-1-o-tolyl-butane-1,2-dione 
• 7332-96-9 1-phenyl-3,3-dimethyl-1,2-butanedione 
• 134-81-6 benzil 
• 926-05-6 tert-butyl nitrate 
• 75-98-9 Trimethylacetic acid 
• 3938-95-2 2,2-dimethyl-propanoic acid ethyl ester 

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