cas 16533-45-2, 2-CARBOXY-3-ETHYL NITROBENZOATE | Articles data ｜lookchem

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16533-45-2

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1-(CYCLOHEXYLOXYCARBONYLOXY)ETHYL 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL]BENZIMIDAZOLE-7-CARBOXYLATE AND COMPOSITIONS AND METHODS OF PHARMACEUTICAL USE THEREOF
1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1 H-tetrazol-5-y l)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.
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(2008/06/13)

Benzimidazole derivatives and their use
Novel imidazole derivatives of the formula (I): STR1 wherein R1 is an optionally substituted alkyl group, R2 and R3 are independently a group capable of forming an anion or a group which can be changed thereinto, ring A is a benzene ring optionally having, besides the group shown by R2, further substituents, and X shows linkage of phenylene group and phenyl group directly or through a spacer whose atomic length is not more than 2 and a salt thereof, show antagonistic actions to angiotensin II, thus being useful as therapeutics for cardiovascular diseases.
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(2008/06/13)

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Chemical Properties

Melting Point: 157 oC**
Boiling Point: 415.5±35.0 °C(Predicted)
Density: 1.421±0.06 g/cm3 (20 oC 760 Torr), Calc.*
Storage Temp.:Sealed in dry,Room Temperature
PKA: 1.90±0.30(Predicted)
PSA: 109.42000
LogP: 1.99290

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