16533-45-2

Basic information

• Product Name: 2-CARBOXY-3-ETHYL NITROBENZOATE
• Synonyms: 2-CARBOXY-3-ETHYL NITROBENZOATE;2-(Ethoxycarbonyl)-6-nitrobenzoic acid;2-Carboxy-3-nitrobenzoic acid ethyl ester;1-Ethyl-3-nitrophthalate;2-(Ethoxycarbonyl)-6-nitrobenzoic Acid 2-
• CAS NO: 16533-45-2
• Molecular Formula: C₁₀H₉NO₆
• Molecular Weight: 239.19
• Mol File: 16533-45-2.mol

Chemical Properties

• Melting Point: 157℃
• Boiling Point: 415.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.421±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.90±0.30(Predicted)
• CAS DataBase Reference: 2-CARBOXY-3-ETHYL NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CARBOXY-3-ETHYL NITROBENZOATE(16533-45-2)
• EPA Substance Registry System: 2-CARBOXY-3-ETHYL NITROBENZOATE(16533-45-2)

Safety Data

• Hazardous Substances Data: 16533-45-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystalline powder

Upstream product

• 64-17-5 ethanol 
• 603-11-2 3-nitrophthalic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 139481-41-7 ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 
• 136285-69-3 ethyl 3-amino-2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>benzoate 
• 136285-67-1 ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]amino-3-nitrobenzoate 
• 136285-65-9 ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate 
• 603-81-6 2,3-diaminobenzoic acid 
• 124340-67-6 2-(4-Acetylamino-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-75-6 2-(2,3-Dimethoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-66-5 2-Biphenyl-4-yl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-55-2 2-(2-Methoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-68-7 2-(4-Dimethylamino-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-56-3 2-(2-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-63-2 2-(4-Methoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-59-6 N'-<2-(N,N-dimethylamino)ethyl>-2-(3'-methoxyphenyl)-1H-benzimidazole-4-carboxamide 
• 124340-54-1 2-o-Tolyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 

Relevant articles and documents

1-(CYCLOHEXYLOXYCARBONYLOXY)ETHYL 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL]BENZIMIDAZOLE-7-CARBOXYLATE AND COMPOSITIONS AND METHODS OF PHARMACEUTICAL USE THEREOF

1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1 H-tetrazol-5-y l)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.

Benzimidazole derivatives and their use

Novel imidazole derivatives of the formula (I): STR1 wherein R1 is an optionally substituted alkyl group, R2 and R3 are independently a group capable of forming an anion or a group which can be changed thereinto, ring A is a benzene ring optionally having, besides the group shown by R2, further substituents, and X shows linkage of phenylene group and phenyl group directly or through a spacer whose atomic length is not more than 2 and a salt thereof, show antagonistic actions to angiotensin II, thus being useful as therapeutics for cardiovascular diseases.