Isonitrile intermediates for the preparation of tri-substituted imidazole compounds with multiple therapeutic properties
The invention relates to a novel group of isonitrile compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.
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Page 25
(2010/01/31)
Imine intermediates for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties
The invention relates to a novel group of iminc compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.
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Page 25
(2010/01/31)
Formamide intermediates for the preparation of tri-substituted imidazole compounds with multiple therapeutic properties
The invention relates to a novel group of formamide compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.
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Page 25
(2010/02/05)
Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes
Pyrimidine analogs of the pyridinylimidazole class of CSBP/p38 kinase inhibitors were prepared in an effort to reduce the potent inhibition of hepatic cytochrome P450 observed for the pyridinyl compounds. The substitution of pyrimidin-4-yl, 2-methoxypyrimidin-4-yl, or 2- methylaminopyrimidin-4-yl for pyridin-4-yl effectively dissociates CSBP/p38 kinase from P450 inhibition for this series and furthermore achieves an increase in oral activity.
Adams, Jerry L.,Boehm, Jeffrey C.,Kassis, Shouki,Gorycki, Peter D.,Webb, Edward F.,Hall, Ralph,Sorenson, Margaret,Lee, John C.,Ayrton, Andrew,Griswold, Don E.,Gallagher, Timothy F.
p. 3111 - 3116
(2007/10/03)
Imidazole compounds, use and process of making
Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
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(2008/06/13)
Compounds
Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
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(2008/06/13)
Pyridyl imidazole compounds and compositions
Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
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(2008/06/13)
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