67751-23-9

Basic information

• Product Name: 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE
• Synonyms: BUTTPARK 43\57-38;1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE;4-(DIMETHYLAMINO)-1,1-DIMETHOXYBUT-3-EN-2-ONE;4-(Dimethylamino)-1,1-dimethoxybut-3-en-2-one, 95+%;[(1E)-4,4-Dimethoxy-3-oxobut-1-en-1-yl]dimethylamine;E-1,1-Dimethoxy-4-dimethylaminobut-3-en-2-one;1,1-DiMethoxyI-4-diMethylaMinobut-3-en-2-one;4-Dimethylamino-1,1-dimethoxy-3-butene-2-one
• CAS NO: 67751-23-9
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.21
• Mol File: 67751-23-9.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 110 °C
• Flash Point: 81.6 °C
• Appearance: /
• Density: 1.008 g/cm³
• Vapor Pressure: 0.184mmHg at 25°C
• Refractive Index: 1.453
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.42±0.70(Predicted)
• CAS DataBase Reference: 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE(67751-23-9)
• EPA Substance Registry System: 1,1-DIMETHOXY-4-DIMETHYLAMINOBUT-3-EN-2-ONE(67751-23-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 67751-23-9(Hazardous Substances Data)

Usage

Uses

4-Dimethylamino-1,1-dimethoxybut-3-en-2-one is used in the preparation of substituted anthranilic amide derivatives as VEGF modulators against cancer and other disorders.

InChI:InChI=1/C8H15NO3/c1-9(2)6-5-7(10)8(11-3)12-4/h5-6,8H,1-4H3/b6-5-

Upstream product

• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 165807-05-6 4-(dimethoxymethyl)pyrimidin-2-amine 
• 25746-87-6 acetal dimethylique du pyrimidine-4 carboxaldehyde 
• 156825-33-1 4-(dimethoxymethyl)-2-(2-pyridyl)pyrimidine 
• 914347-52-7 5-bromo-4-(dimethoxymethyl)pyrimidin-2-amine 
• 874279-26-2 4-(dimethoxymethyl)-2-(methylsulfonyl)pyrimidine 
• 180869-36-7 4-dimethoxymethyl-2-methylsulfanylpyrimidine 
• 27258-32-8 1-methyl-1H-pyrazole-3-carbaldehyde 
• 180869-38-9 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine 

Relevant articles and documents

A PESTICIDALLY ACTIVE MIXTURE COMPRISING PYRAZOLOPYRIDINE ANTHRANILAMIDE COMPOUND, OXIDES OR SALTS THEREOF

The present invention relates to a pesticidal active mixture comprising pyrazolopyridine anthranilamide compound of formula (I), oxides or a salt thereof, Formula (I) wherein, R1, R2, R3, R4, Z and E are as defined in the description, and at least one insecticidally active compound (II) or at least one fungicidally active compound (III).

A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

The mechanistic target of rapamycin (mTOR) plays a pivotal role in growth and tumor progression and is an attractive target for cancer treatment. ATP-competitive mTOR kinase inhibitors (TORKi) have the potential to overcome limitations of rapamycin derivatives in a wide range of malignancies. Herein, we exploit a conformational restriction approach to explore a novel chemical space for the generation of TORKi. Structure-activity relationship (SAR) studies led to the identification of compound 12b with a ～450-fold selectivity for mTOR over class I PI3K isoforms. Pharmacokinetic studies in male Sprague Dawley rats highlighted a good exposure after oral dosing and a minimum brain penetration. CYP450 reactive phenotyping pointed out the high metabolic stability of 12b. These results identify the tricyclic pyrimido-pyrrolo-oxazine moiety as a novel scaffold for the development of highly selective mTOR inhibitors for cancer treatment.

PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME.

The present invention provides novel pyrazolopyridine-diamides of Formula (I), wherein, the definition of W1, W2, A1, A2, A3, B1, B2, D, Z1, E, R1, R2, R3, R4, m and n is as described in the description. The present invention also relates to the composition, combination, use and method of application of the compounds of Formula (I).