- Preparation method of 2-nitroimidazole
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The invention discloses a preparation method of 2-nitroimidazole. The method comprises the following steps: carrying out selective bromination on imidazole as an initial raw material in an imidazole ionic liquid, introducing bromine atoms to the 2-site of the imidazole ring to generate 2-bromoimidazole, and carrying out a nitrosation reaction under the action of a catalyst to obtain 2-nitroimidazole. Based on the defects of difficultly available and expensive raw material 2-aminoimidazole sulfate, risk in use of fluoroboric acid, high copper sulfate consumption and environmental pollution caused by high copper sulfate consumption in the prior art, a new synthesis route is developed, wherein the raw materials are easy to obtain, the steps are short, the cost is low, and the method is environmentally friendly.
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Paragraph 0029; 0030; 0032; 0033; 0035; 0036
(2020/05/01)
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- PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives
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This paper describes a mild phenyliodine diacetate mediated method for selective chlorination, bromination, and iodination of indole C-H bonds using sodium halide as a source for analogous halogenations. The combination of NaX and phenyliodine diacetate provides an invincible system for halogenation of indoles. This protocol was compatible with a wide array of indole substrates and provides straight forward access to potential halogenated arenes.
- Himabindu, Vittam,Parvathaneni, Sai Prathima,Rao, Vaidya Jayathirtha
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p. 18889 - 18893
(2018/11/27)
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- INHIBITORS OF POLO-LIKE KINASE
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The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
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Page/Page column 261
(2012/04/23)
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- PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE
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The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
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Page/Page column 129; 130
(2011/07/09)
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- An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions
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1-Butyl-3-methylpyridinium tribromide, [BMPy]Br3 proves to be a highly efficient, regioselective reagent/solvent for nuclear bromination of various anilines and phenols. The synthesis and characterization of the room temperature ionic liquid [BMPy]Br3 (2) is described. The bromination was carried out in the absence of organic solvents and in most cases the only extraction solvent needed was water. The spent 1-butyl-3-methylpyridinium bromide (1) was easily recycled.
- Borikar, Sanjay P.,Daniel, Thomas,Paul, Vincent
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scheme or table
p. 1007 - 1009
(2009/05/11)
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- THE SYNTHESIS OF VIRIDAMINE, A PENICILLIUM VIRIDICATUM MYCOTOXIN
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The synthesis of viridamine, involving the condensation of 2-(3,3-dimethylallyl)-4(5)-formylimidazole with cyclo-glycyl-L-valyl is described.Different methods for the preparation of the imidazole intermediate were investigated.
- Bond, Roy F.,Bredenkamp, Martin W.,Holzapfel, Cedric W.
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p. 2551 - 2566
(2007/10/02)
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