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Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) is a cyclopentylamine derivative with the molecular formula C5H11NO. It features a unique stereochemistry of (1R,3R)-rel, which is crucial for its biological activity and potential applications in the fields of organic chemistry and pharmaceuticals. Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) serves as a valuable building block in the synthesis of other organic compounds and as a starting material for the development of new drugs.

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  • 167298-58-0 Structure
  • Basic information

    1. Product Name: Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI)
    2. Synonyms: Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI);Trans-3-Aminocyclopentanol(WX600109)
    3. CAS NO:167298-58-0
    4. Molecular Formula: C5H11NO
    5. Molecular Weight: 101.14694
    6. EINECS: N/A
    7. Product Categories: VARIOUSAMINE
    8. Mol File: 167298-58-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 179.4±33.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.084±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 15.06±0.40(Predicted)
    10. CAS DataBase Reference: Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI)(167298-58-0)
    12. EPA Substance Registry System: Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI)(167298-58-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 167298-58-0(Hazardous Substances Data)

167298-58-0 Usage

Uses

Used in Organic Chemistry:
Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) is used as a building block in the synthesis of various organic compounds. Its unique structure and stereochemistry allow for the creation of a wide range of molecules with diverse properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) is used as a starting material for the development of new drugs. Its specific stereochemistry plays a vital role in determining the compound's biological activity, making it a promising candidate for the design and synthesis of innovative pharmaceutical agents.
Used in Drug Synthesis:
Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) is utilized in the synthesis of drugs targeting specific medical conditions. Its unique structure and stereochemistry enable the development of drugs with improved efficacy, selectivity, and reduced side effects.
Used in Chiral Chemistry:
In the field of chiral chemistry, Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) is employed as a chiral building block for the synthesis of enantiomerically pure compounds. Its specific stereochemistry allows for the creation of chiral molecules with distinct biological activities and properties.
Used in Analytical Chemistry:
Cyclopentanol,3-amino-,(1R,3R)-rel-(9CI) can be used as a chiral reference standard in analytical chemistry. Its unique stereochemistry makes it a valuable tool for the identification and quantification of enantiomers in various samples.

Check Digit Verification of cas no

The CAS Registry Mumber 167298-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,2,9 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 167298-58:
(8*1)+(7*6)+(6*7)+(5*2)+(4*9)+(3*8)+(2*5)+(1*8)=180
180 % 10 = 0
So 167298-58-0 is a valid CAS Registry Number.

167298-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Trans-3-Aminocyclopentanol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:167298-58-0 SDS

167298-58-0Relevant articles and documents

Synthesis of Guanine α-Carboxy Nucleoside Phosphonate (G-α-CNP), a Direct Inhibitor of Multiple Viral DNA Polymerases

Maguire, Nuala M.,Ford, Alan,Balzarini, Jan,Maguire, Anita R.

, p. 10510 - 10517 (2018)

The synthesis of guanine α-carboxy nucleoside phosphonate (G-α-CNP) is described. Two routes provide access to racemic G-α-CNP 9, one via base construction and the other utilizing Tsuji-Trost allylic substitution. The latter methodology was also applied to the enantiopure synthesis of both antipodes of G-α-CNP, each of which showing interesting antiviral DNA polymerase activity. Additionally, we report an improved multigram scale preparation of the cyclopentene building block 10, starting material for the preferred Tsuji-Trost route to 9.

Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols

Lee, Jaeyong,Ban, Jeong Woo,Kim, Jeongseok,Yang, Sehun,Lee, Geumwoo,Dhorma, Lama Prema,Kim, Mi-Hyun,Ha, Min Woo,Hong, Suckchang,Park, Hyeung-Geun

, p. 1647 - 1651 (2022/03/03)

The highly enantioselective aza-Michael reaction of tert-butyl β-naphthylmethoxycarbamate to cyclic enones has been accomplished by using a new cinchona alkaloid derived C(9)-urea ammonium catalyst under phase-transfer catalysis conditions with up to 98% ee at 0 °C. The resulting aza-Michael adducts can be converted to versatile intermediates by selective deprotection and the cyclic 1,3-aminoalcohols by diastereoselective reduction with up to 32:1, which have been widely used as important pharmacophores in pharmaceutical development.

KRAS G12C Inhibitor compound and application thereof

-

Paragraph 0141-0142; 0146-0148, (2021/05/12)

The invention provides a KRAS G12C inhibitor compound and an application thereof, and particularly provides a compound as shown in a formula (I), and an optical isomer, a hydrate, a solvate or pharmaceutically acceptable salt thereof. The compound can be used as a KRAS G12C inhibitor and is used for treating diseases related to the activity or expression quantity of KRAS G12C.

Preparation method of (1R,3S)-3-aminocyclopentanol and intermediate thereof

-

, (2020/05/05)

The invention discloses a preparation method of (1R,3S)-3-aminocyclopentanol and an intermediate thereof. The invention provides a preparation method of a compound as shown in a formula I'-1. The preparation method comprises a step: re-crystallizing a mixture of compounds as shown in the formula I'-1 and the formula I'-2 in a solvent, wherein the solvent is a mixed solvent of a poor solvent and agood solvent, the poor solvent is a ketone solvent and methanol, and the good solvent is water. The preparation method is high in reaction yield, and a single-configuration product with high optical purity can be obtained.

Preparation method of (1R,3S)-3-amino-1-cyclopentanol and salt thereof

-

Paragraph 0163-0169, (2020/03/16)

The invention discloses a preparation method of (1R,3S)-3-amino-1-cyclopentanol and a salt thereof, and relates to the field of organic synthesis. In the method, a chiral source in an N-Acyl hydroxylamine compound is used as chiral induction, and an asymm

Preparation of optically-pure cyclic amino alcohol and salt thereof

-

Paragraph 0093-0104, (2020/01/12)

The invention relates to the field of chemical pharmacy, in particular to a method for preparing an optically-pure cyclic amino alcohol and a salt thereof. The method comprises: 1) catalytic hydrogenation: a compound (12) is subjected to catalytic hydroge

Preparation method of optically pure cyclic amino alcohol and salt thereof

-

Paragraph 0098-0103, (2020/01/25)

The invention relates to the field of chemical pharmacy, particularly to a preparation method of optically pure cyclic amino alcohol and a salt thereof. The method comprises 1) hydrolysis: hydrolyzinga compound (12) to obtain a compound (13), and 2) catalytic hydrogenation: carrying out catalytic hydrogenation on the compound (13) obtained in the hydrolysis step to obtain a compound (1).

Method for preparing single-configuration 3-aminocyclopentanol through chiral resolution

-

, (2019/08/12)

The invention relates to a method for preparing a single-configuration 3- aminocyclopentanol through chiral resolution. Specifically, the invention discloses a chiral splitting method of 3-aminocyclopentanol. The preparation method is simple to operate, a

A (1 R, 3 S) -3 - amino-cyclopentanol hydrochloride preparation method (by machine translation)

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Paragraph 0034; 0038, (2019/05/08)

The invention discloses a (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride of the preparation method, the method using chiral carboxylic acid with hydroxylamine to form the amide as chiral source, in copper catalyzed oxidation in the reaction system to rapidly obtain a chiral Diels - alder reaction product, after passes through the reduction reaction and alkaline deprotection reaction, and acidified after reaction to obtain the target product. Chiral inducing reagent chiral carboxylic acid by simple acidification, extraction processing can be reclaimed and reused. This kind of (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride preparation method has high operation safety and high selectivity, raw materials are easy, and the cost is low, the reaction time is short and simple process flow and the like. (by machine translation)

Intermediate for preparing bictegravir and preparation method thereof

-

Paragraph 0110; 0111, (2019/01/08)

The invention relates to the technical field of a drug, and concretely relates to an intermediate for preparing bictegravir and a preparation method thereof. The present invention provides two novel types of compounds and three routes for preparation of a compound (VI). Through substrate induction, chiral catalysis or synergistic effect of substrate induction and chiral catalysis, the stereoselectivity of a Diels-Alder reaction can be greatly improved, and a high chiral purity of a common intermediate (III) can be obtained; cut-out of N-O bond and reduction the double bond use catalytic hydrogenation, which can be environmentally friendly; the reaction conditions are mild, the yield is higher than the existing preparation method, the method is economic and effective, and is adapted to large-scale industrial production.

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