167366-05-4Relevant articles and documents
Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies
Herzon, Seth B.,Menges, Fabian S.,Surovtseva, Yulia V.,Tirla, Alina,Wernke, Kevin M.,Xue, Mengzhao
supporting information, p. 15824 - 15833 (2021/10/02)
Colibactin is a genotoxic metabolite produced by commensal-pathogenic members of the human microbiome that possess the clb (aka pks) biosynthetic gene cluster. clb+ bacteria induce tumorigenesis in models of intestinal inflammation and have been causally
SUBSTITUTED HETEROCYCLICS WITH THERAPEUTIC ACTIVITY IN HIV
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Paragraph 0319-0322, (2021/05/29)
Substituted heterocyclic substituted pyrrole carboxamide compounds such as those represented by Formula I or Formula II are provided herein. Such compounds, or pharmaceutically acceptable salts thereof, can be used in the treatment of HIV infection and re
Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core
Pop, Laura,Lassalas, Pierrik,Bencze, Laszlo Csaba,Tosa, Monica Ioana,Nagy, Botond,Irimie, Florin Dan,Hoarau, Christophe
experimental part, p. 474 - 481 (2012/07/28)
Stereoselective preparative enzymatic acylation and hydrolysis/methanolysis of various C-substituted rac-thiazol-2-yl-methanols were achieved for the preparation of enantiopure or enantiomerically enriched, naturally occurring 2-hydroxymethylthiazoles. The absolute configurations of the resulting secondary alcohols were determined by a detailed 1H NMR study of Mosher's derivatives.
SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS
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Page/Page column 14, (2010/12/29)
Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independentl
FLUORINATED AMINOTRIAZOLE DERIVATIVES
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Page/Page column 46, (2010/12/29)
The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
HETEROCYCLIC DERIVATIVE AND USE THEREOF
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Page/Page column 119, (2011/01/11)
The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like. An sGC activation drug containing a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.
AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS
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Page/Page column 71, (2009/07/18)
The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2- (fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography
Siméon, Fabrice G.,Brown, Amira K.,Zoghbi, Sami S.,Patterson, Velvet M.,Innis, Robert B.,Pike, Victor W.
, p. 3256 - 3266 (2008/02/09)
2-Fluoromethyl analogs of (3-[(2-methyl-1,3-thiazol-4yl)ethynyl]pyridine) were synthesized as potential ligands for metabotropic glutamate subtype-5 receptors (mGluR5s). One of these, namely, 3-fluoro-5-(2-(2-(fluoromethyl) thiazol-4-yl)ethynyl)benzonitri
Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
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Page/Page column 9, (2008/06/13)
Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy
Nicolaou,King,Finlay,He,Roschangar,Vourloumis,Vallberg,Sarabia,Ninkovic,Hepworth
, p. 665 - 697 (2007/10/03)
A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),