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4-Bromo-2-formylthiazole, a chemical compound with the molecular formula C5H3BrNOS, is a thiazole derivative characterized by a five-membered aromatic heterocycle containing both sulfur and nitrogen atoms. It is recognized for its versatility in organic chemistry and drug discovery, serving as a reagent in the synthesis of pharmaceuticals, agrochemicals, and various biologically active compounds. Its potential antimicrobial and antibacterial properties further contribute to its significance in the development of new drug candidates.

167366-05-4

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167366-05-4 Usage

Uses

Used in Organic Synthesis:
4-Bromo-2-formylthiazole is used as a reagent in organic synthesis for the preparation of pharmaceuticals and agrochemicals, owing to its unique structural features and reactivity.
Used in Pharmaceutical Industry:
In the Pharmaceutical Industry, 4-Bromo-2-formylthiazole is utilized as an intermediate in the synthesis of biologically active compounds, contributing to the development of novel therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the Agrochemical Industry, 4-Bromo-2-formylthiazole serves as an intermediate, playing a crucial role in the creation of new agrochemical products.
Used in Drug Discovery:
4-Bromo-2-formylthiazole is used in drug discovery for its potential antimicrobial and antibacterial properties, making it a valuable candidate for the development of new antimicrobial drugs to combat resistant infections.

Check Digit Verification of cas no

The CAS Registry Mumber 167366-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,3,6 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 167366-05:
(8*1)+(7*6)+(6*7)+(5*3)+(4*6)+(3*6)+(2*0)+(1*5)=154
154 % 10 = 4
So 167366-05-4 is a valid CAS Registry Number.

167366-05-4 Well-known Company Product Price

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  • Aldrich

  • (699284)  4-Bromothiazole-2-carboxaldehyde  96%

  • 167366-05-4

  • 699284-1G

  • 959.40CNY

  • Detail

167366-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromo-2-formylthiazole

1.2 Other means of identification

Product number -
Other names 4-bromo-1,3-thiazole-2-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:167366-05-4 SDS

167366-05-4Relevant articles and documents

Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies

Herzon, Seth B.,Menges, Fabian S.,Surovtseva, Yulia V.,Tirla, Alina,Wernke, Kevin M.,Xue, Mengzhao

supporting information, p. 15824 - 15833 (2021/10/02)

Colibactin is a genotoxic metabolite produced by commensal-pathogenic members of the human microbiome that possess the clb (aka pks) biosynthetic gene cluster. clb+ bacteria induce tumorigenesis in models of intestinal inflammation and have been causally

SUBSTITUTED HETEROCYCLICS WITH THERAPEUTIC ACTIVITY IN HIV

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Paragraph 0319-0322, (2021/05/29)

Substituted heterocyclic substituted pyrrole carboxamide compounds such as those represented by Formula I or Formula II are provided herein. Such compounds, or pharmaceutically acceptable salts thereof, can be used in the treatment of HIV infection and re

Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core

Pop, Laura,Lassalas, Pierrik,Bencze, Laszlo Csaba,Tosa, Monica Ioana,Nagy, Botond,Irimie, Florin Dan,Hoarau, Christophe

experimental part, p. 474 - 481 (2012/07/28)

Stereoselective preparative enzymatic acylation and hydrolysis/methanolysis of various C-substituted rac-thiazol-2-yl-methanols were achieved for the preparation of enantiopure or enantiomerically enriched, naturally occurring 2-hydroxymethylthiazoles. The absolute configurations of the resulting secondary alcohols were determined by a detailed 1H NMR study of Mosher's derivatives.

SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS

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Page/Page column 14, (2010/12/29)

Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independentl

FLUORINATED AMINOTRIAZOLE DERIVATIVES

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Page/Page column 46, (2010/12/29)

The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

HETEROCYCLIC DERIVATIVE AND USE THEREOF

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Page/Page column 119, (2011/01/11)

The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like and useful as an sGC activation drug, or an agent for the prophylaxis and/or treatment of diseases such as hypertension, ischemic cardiac disease, cardiac failure, kidney disease, arteriosclerotic disease, atrial fibrillation, pulmonary hypertension, diabetes, diabetic complications, metabolic syndrome, peripheral arterial obstruction, erectile dysfunction and the like. An sGC activation drug containing a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof, as an active ingredient.

AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS

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Page/Page column 71, (2009/07/18)

The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.

Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2- (fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography

Siméon, Fabrice G.,Brown, Amira K.,Zoghbi, Sami S.,Patterson, Velvet M.,Innis, Robert B.,Pike, Victor W.

, p. 3256 - 3266 (2008/02/09)

2-Fluoromethyl analogs of (3-[(2-methyl-1,3-thiazol-4yl)ethynyl]pyridine) were synthesized as potential ligands for metabotropic glutamate subtype-5 receptors (mGluR5s). One of these, namely, 3-fluoro-5-(2-(2-(fluoromethyl) thiazol-4-yl)ethynyl)benzonitri

Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors

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Page/Page column 9, (2008/06/13)

Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.

Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy

Nicolaou,King,Finlay,He,Roschangar,Vourloumis,Vallberg,Sarabia,Ninkovic,Hepworth

, p. 665 - 697 (2007/10/03)

A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),

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