17200-29-2Relevant articles and documents
An efficient synthesis of benzoxazoles using silica-supported tin exchanged silicotungstic acid catalyst
Srivani,Venkateswar Rao,Sai Prasad,Lingaiah
, p. 119 - 123 (2010)
An efficient method for the preparation of benzoxazoles by reacting aminophenols with orthoesters in the presence of silica-supported tin exchanged silicotungstic acid catalyst under mild conditions with high yield and selectivity is demonstrated. The catalysts were characterized by FT-IR and pyridine adsorbed FT-IR. The catalyst exhibited consistent activity upon recycling and is highly active compared to other catalysts. The role of Lewis acidity of the catalysts and plausible reaction mechanism is presented.
Visible Light-Induced Copper-Catalyzed C—H Arylation of Benzoxazoles?
Ma, Xiaodong,Zhang, Guozhu
supporting information, p. 1299 - 1303 (2020/08/05)
A general method for visible light-induced copper-catalyzed arylation of sp2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzooxazole and benzothiazole can be arylated. Furthermore, electron-poor heterocycles such as thiophene possessing one electron-withdrawing group can also be arylated.
Room-temperature palladium-catalyzed direct 2-alkenylation of azole derivatives with alkenyl bromides
Yao, Yun-Xin,Fang, Dong-Mei,Gao, Feng,Liang, Xiao-Xia
supporting information, p. 68 - 71 (2018/12/05)
Pd-catalyzed direct C2-alkenylation of azole derivatives proceeds efficiently under mild conditions, and the reaction of substituted benzoxazoles, oxazole and benzothiazole occurred even at room temperature. The substrate scope of the reaction was turned out to include mono-, di- and trisubstituted alkenyl bromides. To validate the scalability of this method, 5-Methyl-2-(prop-1-en-2-yl)benzoxazole (3c) was prepared on one-gram scale at room temperature.
Cu-Catalyzed Direct C-P Bond Formation through Dehydrogenative Cross-Coupling Reactions between Azoles and Dialkyl Phosphites
Hore, Soumyadip,Srivastava, Abhijeet,Singh, Ravi P.
, p. 6868 - 6878 (2019/06/14)
A direct dehydrogenative cross-coupling of azoles [C(sp2)-H] with dialkyl phosphites [P(O)-H] to access 2-phosphonated azoles using Cu(I)/Cu(II) as catalyst and K2S2O8/di-tert-butylperoxide as oxidant has been achieved. A remarkable advantage over reported procedures includes that oxazoles, imidazoles, benz(ox/othi/imid)azoles, and indole are found to react under optimized reaction conditions to provide corresponding adducts in high yields. The mechanistic insight of cross-coupling was obtained by deuterium kinetic isotope effect studies.
Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase
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Paragraph 0072, (2019/03/08)
The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).
PROCESS FOR THE PREPARATION OF SUVOREXANT AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF SUVOREXANT
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Paragraph 0118-0119, (2016/07/05)
A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)
Process for the preparation of an intermediate for an orexin receptor antagonist
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Paragraph 10; 11, (2017/02/02)
The present invention is directed to processes for preparing an intermediate for a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.
Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers
Li, Yanrong,Wang, Mengshi,Fan, Wei,Qian, Fen,Li, Guigen,Lu, Hongjian
, p. 11743 - 11750 (2016/12/09)
The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO3 as an inexpensive catalyst at levels as low as 1.0 mol %. In
Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids
Chen, Lijun,Ju, Lin,Bustin, Katelyn A.,Hoover, Jessica M.
supporting information, p. 15059 - 15062 (2015/10/12)
A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.
Direct C-H iodination of 1,3-azoles catalysed by CuBr2
Zhao, Xia,Ding, Fang,Li, Jingyu,Lu, Kui,Lu, Xiaoyu,Wang, Bin,Yu, Peng
supporting information, p. 511 - 513 (2015/02/19)
A mild method was developed for the direct C-H iodination of 1,3-azoles catalysed by CuBr2. Compared with the traditional metalation/iodination sequences carried out with nBuLi or TMPLi (TMP = 2,2,6,6-tetramethylpiperidino), a relatively weaker base, LiOtBu, was used in the presence of 1,10-phenanthroline. Five series of 1,3-azoles, including benzoxazole, benzothiozole, N-methyl-benzoimidazole, 5-phenyloxazole and 2-phenyl-1,3,4-oxadiazole were tested and afforded the corresponding iodination products.
