172527-71-8Relevant articles and documents
Method for synthesizing fluopyram
-
Paragraph 0040; 0056-0058; 0072; 0088-0090, (2021/11/10)
The method comprises the following steps: 2, 3 -dichloro-trifluorotoluene is subjected to fluorination, cyano substitution, hydrolysis, hydroxymethylation, and esterification to obtain the intermediate 5. Another 2, 3 - dichloro -5 -trifluoromethylpyridine is reacted with malonic acid diester to give intermediate 6. After the intermediate 5 is condensed with the intermediate 6, hydrolysis, decarboxylation, and final hydrogenation dechlorination are performed to obtain fluopyram. The method has the characteristics of simple operation, cheap and accessible raw materials, no participation of isomers 1 isomers in subsequent reaction and easy removal. Non-flammable and explosive, highly toxic or non-volatile agents commonly used in the existing synthetic method are not used in each reaction step, and harm to operating personnel and in the environment is avoided. , The yield of the product reaches above 50%, and the purity is 98% or more.
Convenient routes to trifluoromethyl-substituted pyridyl-isothiocyanates and isocyanates starting from 2,3-dichloro-5-trifluoromethyl pyridine
Fodor, Elena,Maftei, Catalin-Vasile,Mangalagiu, Ionel,Jones, Peter G.,Daniliuc, Constantin-Gabriel,Franz, M. Heiko,Neda, Ion
experimental part, p. 559 - 564 (2011/08/22)
A convenient preparative route for the synthesis of 3-chloro-2- (isothiocyanatoethyl)-5-(trifluoromethyl)pyridine (1) and 3-chloro-2- (isocyanatoethyl)-5-(trifluoromethyl)pyridine (2) has been developed, involving 5 steps starting from 2, 3-dichloro-5-(trifluoromethyl)pyridine (3). All intermediates and final products were obtained in good yields and purity. The structure of one intermediate, 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl) malonate, was confirmed by X-ray crystallography.
Process for the Preparation of a 2-Pyridylethylcarboxamide Derivative
-
Page/Page column 12, (2008/06/13)
Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carbox-amide derivative of general formula (I) or a salt thereof 5 Intermediate of general formula (II) Intermediate of general formula (III).