658066-35-4

Basic information

• Product Name: Fluopyram
• Synonyms: N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide; T6NJ B2MVR BXFFF& CG EXFFF; luopyram; N-[2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide; N-{2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]ethyl}-α,α,α-trifluoro-o-toluamide
• CAS NO: 658066-35-4
• Molecular Formula: C₁₆H₁₁ClF₆N₂O
• Molecular Weight: 396.7148
• Mol File: 658066-35-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 432.3°C at 760 mmHg
• Flash Point: 215.2°C
• Density: 1.42g/cm³
• Vapor Pressure: 1.12E-07mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: Fluopyram(CAS DataBase Reference)
• NIST Chemistry Reference: Fluopyram(658066-35-4)
• EPA Substance Registry System: Fluopyram(658066-35-4)

Safety Data

• Hazardous Substances Data: 658066-35-4(Hazardous Substances Data)

Usage

General Description

Fluopyram is a broad-spectrum fungicide and nematicide that belongs to the group of succinate dehydrogenase inhibitors (SDHI). It is used to control a wide variety of fungal diseases in various crops, including cereals, fruits, vegetables, and ornamentals. Fluopyram works by inhibiting the succinate dehydrogenase enzyme, which disrupts the energy production in the target organisms, ultimately leading to their death. It has a relatively low toxicity to mammals and non-target organisms, making it an attractive option for integrated pest management programs. However, it is important to use fluopyram responsibly and according to label instructions to minimize the risk of resistance development and environmental impact.

Upstream product

• 658066-44-5 2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1-ethanamine 
• 312-94-7 2-trifluoromethylbenzoyl chloride 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 433-97-6 2-trifluoromethylbenzoic acid 
• 360-64-5 2-(trifluoromethyl)benzamide 
• 895525-70-9 N-hydroxymethyl-2-(trifluoromethyl)benzamide 
• 895525-76-5 dimethyl [3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[2-(trifluoromethyl)benzoyl]amino}methyl)malonate 
• 157764-10-8 2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile 
• 75806-84-7 2-bromo-3-chloro-5-(trifluoromethyl)pyridine 
• 1450903-41-9 2-(trifluoromethyl)-N-vinylbenzamide 
• 895525-74-3 C₂₂H₁₉ClF₆N₂O₅ 
• 916420-45-6 2-chloro-6-trifluoromethylbenzamide 
• 129604-28-0 2-chloro-6-trifluoromethylbenzonitrile 
• 54773-19-2 1,2-dichloro-3-(trifluoromethyl)benzene 

Downstream Products

• 1431755-58-6 N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1-methoxyethyl}-2-(trifluoromethyl)benzamide 
• 1431842-78-2 N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene}-2-(trifluoromethyl)benzamide 
• 1431755-59-7 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1-{[2-(trifluoromethyl)benzoyl]amino}ethyl acetate 

Relevant articles and documents

Method for hydrolyzing and decarboxylating aromatic dicarboxylic ester

The invention discloses a method for hydrolyzing and decarboxylating aromatic dicarboxylic ester. The method comprises the following steps: adding aromatic dicarboxylic ester, an acid catalyst, water and an alcohol solvent into a high-pressure reaction kettle with an automatic pressure relief device, carrying out heat-preservation decarboxylation reaction for 3-6 hours under constant pressure, recovering the solvent under negative pressure after the reaction is completed, cooling, crystallizing, and centrifugally drying to obtain a decarboxylation product. According to the method, a constant-pressure one-pot hydrolysis decarboxylation method is adopted, the problems of material decomposition and coking caused by traditional high-temperature hydrolysis decarboxylation are solved, the operation process is simplified, the production efficiency is improved, meanwhile, the amount of waste salt is reduced, and the environment-friendly treatment cost is reduced. The hydrolyzing and decarboxylating method has the characteristics of low cost, high yield, simple process operation and the like, and is suitable for large-scale production.

Method for synthesizing fluopyram

The invention provides a method for synthesizing fluopyram, which uses commercially available 2 - bromoethylamine hydrobromide as a starting raw material, generates cyclopropylamine by self nucleophilic substitution reaction under basic conditions, and then reacts with o-trifluorobenzoyl chloride to prepare the key intermediate cyclopropylamine -1 -(2 - (trifluoromethyl) phenyl) methyl ketone. 2,3 -dichloro -5 -trifluoromethylpyridine was reacted with cyclopropylamine -1 -based (2 - (trifluoromethyl) phenyl) methyl ketone after the action of alkyllithium to give fluopyram. 1st-step and 2nd-step reactions are one-pot reaction, the reaction yield is high, the synthesis process is simple, the product purity is high, and the method has huge application value.

Synthesis method of benzamide compound (by machine translation)

The synthesis method of N - [2 - [3 -(trifluoromethyl)-pyridin - 2 2-yl] ethyl] - 2 - (Trifluoromethyl-)-ethyl- Trifluoromethyl-2,3 -trifluoromethyl) benzamide,) yields, chloro - 5 5 5-(trifluoromethyl pH＝2-5 pyri- 2 2-based N,N -Trifluoromethyl-3 -Trifluoromethyl) - 2 -ethyl,trifluoromethyl-3 -benzamide,).) - 2 - The synthesis method employed in the present invention is obtained by catalytic hydrogenation . The N - [2 - [3 - reaction mother liquid 2 - (obtained by the present invention is synthesized by a method of, synthesizing)% N - [2 - [3 -chloro - 5 5 5-(trifluoromethylpyridin - 2 2-methyl-).trifluoromethylpyridine]) as a starting material under the action, of a, catalyst and a base by, catalytic hydrogenation to obtain a compound] - 2 - (g - 5) 5 5-] (] - 2 - (trifluormethyl) pyridine)-2-). trifluoromethylbenzenesulfonamide. (by machine translation)