173025-79-1

Basic information

• Product Name: 4-(4-TrifluoroMethoxyphenyl)phenol
• Synonyms: 4-(4-TrifluoroMethoxyphenyl)phenol;4'-(Trifluoromethoxy)-[1,1'-biphenyl]-4-ol
• CAS NO: 173025-79-1
• Molecular Formula: C₁₃H₉F₃O₂
• Molecular Weight: 254.2045696
• Mol File: 173025-79-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-TrifluoroMethoxyphenyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-TrifluoroMethoxyphenyl)phenol(173025-79-1)
• EPA Substance Registry System: 4-(4-TrifluoroMethoxyphenyl)phenol(173025-79-1)

Safety Data

• Hazardous Substances Data: 173025-79-1(Hazardous Substances Data)

Upstream product

• 139301-27-2 4-trifluoromethoxyphenylboronic acid 
• 106-41-2 4-bromo-phenol 
• 5720-07-0 4-methoxyphenylboronic acid 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 777063-53-3 4-methoxy-4′-(trifluoromethoxy)-1,1′-biphenyl 

Downstream Products

• 220616-04-6 (R)-1-Benzyloxy-3-(4'-trifluoromethoxy-biphenyl-4-yloxy)-propan-2-ol 
• 220616-11-5 3-((2S)-2-(N-hydroxyamino)-3-((4'-(trifluoromethoxy)(1,1'-biphenyl)-4-yl)oxy)propyl)-5,5-dimethyl-2,4-imidazolidinedione 
• 220616-06-8 C₃₃H₃₈F₃NO₈ 
• 364731-97-5 C₃₁H₃₈F₃N₃O₉ 
• 173025-60-0 4-[3-(4-trifluoromethoxybiphenyl-4'-oxy)propoxy]-1,3-diaminobenzene 
• 1263417-22-6 4-[(1S)-(2-benzyloxy-1-{triisopropylsilyloxymethyl}ethyl)oxy]-4'-trifluoromethoxy-1,1'-biphenyl 

Relevant articles and documents

Exploiting Coupling of Boronic Acids with Triols for a pH-Dependent click-Declick Chemistry

Click-like condensation of boronic acids with specifically designed triols (boronate-triol coupling) produces stable diamantane adducts in aqueous medium, which can be controllably cleaved to initial components under acidic conditions or by using boric acid as a chemical trigger. This novel click-declick strategy allows for the creation of temporary covalent connections between two or more modular units, which was demonstrated by the synthesis of new fluorophore-labeled natural molecules (peptides, steroids), supramolecular assemblies, modified polymers, boronic acid scavengers, solid-supported organocatalysts, biodegradable COF-like materials, and dynamic combinatorial libraries.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Photopolymerizable oxetane derivative and liquid-crystal composition containing it

Provided are a liquid-crystal compound and a liquid-crystal composition containing the compound, of which the advantages are that they show nematic hybrid orientation on a rubbed TAC substrate, they are polymerizable in open air and they readily give a po

ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.

The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERbeta selectivity on the order of 20-70-fold.

Ionic Liquid Acceleration of Solid-Phase Suzuki-Miyaura Cross-Coupling Reactions

(Equation Presented) Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki-Miyaura cross-coupli

Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770

Modification of the biphenyl portion of MMP inhibitor 2a gave analogue 2i which is greater than 1000-fold selective against MMP-2 versus MMP-1. The stereospecific synthesis of both enantiomers of 2i was achieved beginning with (S)- or (R)-benzyl glycidyl ether. The (S)-enantiomer, 11 (ABT-770), is orally bioavailable and efficacious in an in vivo model of tumor growth. Elsevier Science Ltd. All rights reserved.