17321-35-6

Basic information

• Product Name: 3-Iodo-6-methoxypyridazine
• Synonyms: 3-Iodo-6-methoxypyridazine;3-Iodo-6-methoxy-1,2-diazine;Pyridazine,3-iodo-6-methoxy-
• CAS NO: 17321-35-6
• Molecular Formula: C₅H₅IN₂O
• Molecular Weight: 236.01
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 17321-35-6.mol

Chemical Properties

• Boiling Point: 334°Cat760mmHg
• Flash Point: 155.8°C
• Appearance: /
• Density: 1.935g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Iodo-6-methoxypyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-6-methoxypyridazine(17321-35-6)
• EPA Substance Registry System: 3-Iodo-6-methoxypyridazine(17321-35-6)

Safety Data

• Hazardous Substances Data: 17321-35-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Iodo-6-methoxypyridazine is used as a building block in organic synthesis for its versatile reactivity and structural features. Its unique combination of a pyridazine core, methoxy group, and iodine atom allows for the creation of a variety of complex organic molecules, making it a valuable component in the synthesis of pharmaceuticals and other bioactive compounds.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-Iodo-6-methoxypyridazine is employed as a key intermediate for the development of novel pharmaceuticals. Its presence in various drug candidates contributes to their biological activities, including anti-inflammatory and antimicrobial properties. Researchers leverage its structural attributes to design and optimize new therapeutic agents with improved efficacy and selectivity.
Used in Anti-Inflammatory Agents:
3-Iodo-6-methoxypyridazine is utilized as an anti-inflammatory agent due to its ability to modulate inflammatory pathways and reduce the associated symptoms. Its incorporation into pharmaceutical formulations can provide relief from inflammation and related conditions, offering a promising avenue for the treatment of various inflammatory diseases.
Used in Antimicrobial Agents:
3-Iodo-6-methoxypyridazine also serves as an antimicrobial agent, exhibiting activity against a range of microorganisms, including bacteria and fungi. The presence of the iodine atom and the methoxy group on the pyridazine core contributes to its antimicrobial properties, making it a valuable component in the development of new antibiotics and antifungal medications to combat drug-resistant infections.
Overall, 3-Iodo-6-methoxypyridazine is a multifaceted chemical entity with broad applications across various industries, particularly in the pharmaceutical sector, where its unique structural features and pharmacological activities are harnessed to advance the discovery and development of innovative therapeutic agents.

InChI:InChI=1/C5H5IN2O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 20698-04-8 3,6-diiodopyridazine 
• 67-56-1 methanol 

Downstream Products

• 68321-53-9 3-(phenylethynyl)-6-methoxypyridazine 
• 4578-42-1 3-methoxy-6-phenylpyridazine 
• 1019331-16-8 3-ethynyl-6-methoxypyridazine 
• 173088-61-4 (E)-p-nitrophenyl 3-(2-methoxy-5-pyridazinyl)acrylate 
• 99984-42-6 6-methoxy-3-(phenylsulfanyl)pyridazine 

Relevant articles and documents

First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents

Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular c

New water-soluble duocarmycin derivatives: Synthesis and antitumor activity of A-ring pyrrole compounds bearing β-heteroarylacryloyl groups

A series of A-ring pyrrole compounds of duocarmycin bearing 4'-methoxy- β-heteroarylacryloyl groups were synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 18

Synthesis of some 3,6-disubstituted pyridazines

Some novel 3-halo-6-(4-substituted-phenoxy)pyridazines and 3,6-di-(4- substituted-phenoxy)pyridazines were synthesized from 3,6-dichloropyridazine or 3,6-diiodopyridazine. 3,6-Diiodopyridazine was prepared from 3,6- dichloropyridazine using hydriodic acid/iodine monochloride.

DC-89 derivatives

Provided are DC-89 derivatives represented by the formula: STR1 wherein X represents Cl or Br, R represents hydrogen or COR1, and W represents STR2 and pharmaceutically acceptable salts thereof. The compounds of the present invention have excellent anti-tumor activity and are useful as anti-tumor agents.