4578-42-1

Basic information

• Product Name: 3-methoxy-6-phenylpyridazine
• Synonyms: 3-methoxy-6-phenylpyridazine
• CAS NO: 4578-42-1
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• Mol File: 4578-42-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 382.109°C at 760 mmHg
• Flash Point: 138.962°C
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-methoxy-6-phenylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-6-phenylpyridazine(4578-42-1)
• EPA Substance Registry System: 3-methoxy-6-phenylpyridazine(4578-42-1)

Safety Data

• Hazardous Substances Data: 4578-42-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 748, 1995 DOI: 10.1021/jo00108a049

InChI:InChI=1/C11H10N2O/c1-14-11-8-7-10(12-13-11)9-5-3-2-4-6-9/h2-8H,1H3

Upstream product

• 1722-10-7 3-chloro-6-methoxypyridazine 
• 100-59-4 phenylmagnesium chloride 
• 591-50-4 iodobenzene 
• 17321-35-6 3-methoxy-6-iodopyridazine 
• 98-80-6 phenylboronic acid 
• 20375-65-9 3-chloro-6-phenylpyradazine 
• 124-41-4 sodium methylate 

Downstream Products

• 10330-57-1 3-methoxy-4-methyl-6-phenylpyridazine 
• 332135-30-5 (3-methoxy-6-phenylpyridazin-4-yl)(phenyl)methanol 
• 64657-93-8 4-benzyl-3-methoxy-6-phenyl-pyridazine 
• 1015480-94-0 3-methoxy-6-phenyl-4-pyridazinylboronic acid 
• 1015480-97-3 3-methoxy-6-phenyl-4-(pyrimidin-5-yl)pyridazine 
• 1015480-96-2 3-methoxy-6-phenyl-4-(pyridin-2-yl)pyridazine 
• 852617-62-0 4-iodo-3-methoxy-6-phenyl-pyridazine 
• 13300-09-9 4-methyl-6-phenylpyridazin-3(2H)-one 
• 28657-39-8 3-chloro-4-methyl-6-phenylpyridazine 
• 25905-77-5 minaprine 
• 14959-34-3 3-bromo-6-phenylpyridazine 
• 2166-31-6 6-phenylpyridazin-3-ol 

Relevant articles and documents

Core-Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties

In this work on the design and studies of luciferins related to the blue-hued coelenterazine, the synthesis of heterocyclic analogues susceptible to produce a photon, possibly at a different wavelength, is undertaken. Here, the synthesis of O-acetylated derivatives of imidazo[1,2-b]pyridazin-3(5 H)-one, imidazo[2,1-f][1,2,4]triazin-7(1 H)-one, imidazo[1,2-a]pyridin-3-ol, imidazo[1,2-a]quinoxalin-1(5 H)-one, benzo[f]imidazo[1,2-a]quinoxalin-3(11 H)-one, imidazo[1′,2′:1,6]pyrazino[2,3-c]quinolin-3(11 H)-one, and 5,11-dihydro-3 H-chromeno[4,3-e]imidazo[1,2-a]pyrazin-3-one is described thanks to extensive use of the Buchwald–Hartwig N-arylation reaction. The acidic hydrolysis of these derivatives then gave solutions of the corresponding luciferin analogues, which were studied. Not too unexpectedly, even if these were “dressed” with substituents found in actual substrates of the nanoKAZ/NanoLuc luciferase, no bioluminescence was observed with these compounds. However, in a phosphate buffer, all produced a light signal, by chemiluminescence, with extensive variations in their respective intensity and this could be increased by adding a quaternary ammonium salt in the buffer. This aspect was actually instrumental to determine the emission spectra of many of these luciferin analogues.

Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents

A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.

Pyridazine and Pyrrole Compounds, Processes For Obtaining Them and Uses

The present invention relates to nonlinear oligopyridazine compounds, to processes for obtaining them, to their uses, and also to their reduction to oligopyrroles and to the uses of the pyridazinylpyrrole and oligopyrrole compounds obtained. The invention relates in particular to the uses as medicaments, in particular for treating pathologies such as cancer, bacterial infections or parasitic infections, and also the uses in the materials, environmental, electronics and optics field.