1756-18-9

Basic information

• Product Name: alpha,beta-dihydroxyisovaleric acid
• Synonyms: alpha,beta-dihydroxyisovaleric acid;2,3-dihidroxy-3-methyl-butanoate;2,3-Dihydroxyisovaleric acid;2,3-dihydroxy-3-methylbutanoic acid
• CAS NO: 1756-18-9
• Molecular Formula: C₅H₁₀O₄
• Molecular Weight: 134.13
• Mol File: 1756-18-9.mol

Chemical Properties

• Boiling Point: 332.2 °C at 760 mmHg
• Flash Point: 168.9 °C
• Appearance: /
• Density: 1.326 g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: alpha,beta-dihydroxyisovaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: alpha,beta-dihydroxyisovaleric acid(1756-18-9)
• EPA Substance Registry System: alpha,beta-dihydroxyisovaleric acid(1756-18-9)

Safety Data

• Hazardous Substances Data: 1756-18-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
alpha,beta-dihydroxyisovaleric acid is used as an intermediate compound for the synthesis of various pharmaceuticals and biologically active molecules. Its ability to form hydrogen bonds and interact with other molecules makes it a valuable building block in drug development.
Used in Chemical Synthesis:
alpha,beta-dihydroxyisovaleric acid is used as a key component in the synthesis of complex organic molecules, particularly in the fields of organic chemistry and materials science. Its unique functional groups allow for a wide range of reactions and modifications, leading to the creation of novel compounds with specific properties.
Used in Research and Development:
alpha,beta-dihydroxyisovaleric acid serves as a valuable research tool for studying the properties and reactivity of dihydroxy monocarboxylic acids. It can be used to investigate various chemical reactions, mechanisms, and the development of new synthetic methods.
Used in Analytical Chemistry:
alpha,beta-dihydroxyisovaleric acid can be employed as a reference compound or standard in analytical chemistry for the calibration of instruments and the development of new analytical techniques. Its distinct chemical properties make it suitable for various analytical applications.

InChI:InChI=1/C5H10O4/c1-5(2,9)3(6)4(7)8/h3,6,9H,1-2H3,(H,7,8)

Upstream product

• 541-47-9 3-Methylbutenoic acid 
• 1578-05-8 1,1,3-tribromo-3-methyl-butan-2-one 
• 7664-93-9 sulfuric acid 
• 4374-53-2 3,3-dimethyl-oxirane-2-carboxylic acid 
• 7732-18-5 water 
• 5369-63-1 ethyl 3,3-dimethyl-oxirane-2-carboxylate 

Downstream Products

• 80567-47-1 methyl-(+/-)-2,3-dihydroxy-3-methylbutyrate 
• 19451-56-0 D(-)-α,β-dihydroxyisovaleric acid 
• 78-84-2 isobutyraldehyde 
• 6546-31-2 α-oxo-β-hydroxyisovaleric acid 
• 594-61-6 2-methyllactic acid 
• 20818-81-9 2-hydroxy-2-methylpropanal 
• 37504-91-9 methyl (R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-carboxylate 
• 37504-90-8 (R)-α,β-dihydroxyisovaleric methyl ester 
• 109275-23-2 (S)-(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methylamine 
• 109275-22-1 (R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-carboxamide 
• 109275-24-3 (S)-N-<(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>acetamide 
• 86562-72-3 S(-)methyl-3 butanetriol-1,2,3 
• 82010-40-0 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3,3-dimethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl ester 
• 82010-48-8 2,2,2-Trifluoro-N-[(2S,3R,5S)-5-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-tetrahydro-furan-3-yl]-acetamide 

Relevant articles and documents

Kinetics and Mechanism of the Oxidation of Unsaturated Carboxylic Acids by Methyltributylammonium Permanganate in Methylene Chloride Solutions

The product obtained when permanganate is reduced by unsaturated carboxylic acids under anhydrous conditions is manganese(III).The rate of reaction, which is subject to acid catalysis, exhibits a Hammet ρ value of 1.11 and inverse secondary isotope effects (kH/kD = 0.96-0.98) when the hydrogens on the double bond are replaced by deuterium.The involvement of a free-radical process is indicated by the formation of polymer during the oxidation of acrylic and methacrylic acids.The reaction is believed to be initiated by formation of an organometallic complex in which the double bond is a η2 ligand on manganese.Rearrangement of this complex results in the formation of a reactive manganate(V) cyclic diester, which undergoes a rapid (free-radical) reduction to manganese(III).

Synthesis of Enantiomerically Pure Forms of N-Acyl Derivatives of C-Methyl Analogues of the Aminodeoxy Sugar L-Acosamine from Noncarbohydrate Precursors

The 2S,3R diol 2a and the 3R α-ketol 5b, prepared in fermenting baker's yeast from cinnamaldehyde and α-methylcinnamaldehyde, are converted into the chiral N-trifluoroacetyl deoxy C-methyl-branched amino sugars 15b,c and 19b.Key intermediates in the synthesis are the C4 and C5 chiral aldehydes 9a and 17a and the α,β-unsaturated carbonyl compounds 11a and 18, which upon threo stereoselective addition of ammonia, eventually give 15b,c and 19b.The sterochemistry and the conformations of the aminodeoxy sugar derivatives and of the intermediate lactones are deduced byNMR studies.