5369-63-1Relevant articles and documents
Preparation method of calcium [beta]-hydroxy-[beta]-methylbutyrate
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Paragraph 0025; 0027-0052, (2020/07/24)
The invention discloses a preparation method of calcium [beta]-hydroxy-[beta]-methylbutyrate, which comprises the following steps: S1) condensation reaction: adding ethyl chloroacetate and acetone into a solvent, and dropwisely adding an alkali solution to obtain a 3, 3-dimethyl oxide-2-carboxylic acid ethyl ester solution; S2) hydrolysis reaction: adding an aqueous solution of alkali into a solution of 3, 3-dimethyl oxide-2-carboxylic acid ethyl ester, and performing acidifying to obtain 3, 3-dimethyl oxide-2-carboxylic acid; S3) hydrogenation reaction: adding 3, 3-dimethyl oxide-2-carboxylicacid into the Pt/C alcohol system, and performing hydrogenation to obtain [beta]-hydroxy-[beta]-methylbutyrate acid; and S4) salifying reaction: adding water, calcium salt and a catalyst into the organic solution of [beta]-hydroxy-[beta]-methylbutyrate acid to react, and performing filtering, pulping and drying to prepare the finished product calcium [beta]-hydroxy-[beta]-methylbutyrate. The preparation method disclosed by the invention is simple in process, easy to operate, environment-friendly, free of pollution, safe in calcium reagent, free of residue, low in cost, safe to operate, easy for industrial large-scale production, high in conversion rate and good in product quality.
Synthetic studies towards pectenotoxin-2: Synthesis of the nonanomeric 10-epi-ABCDE ring segment by kinetic spiroketalization
Aho, Jatta E.,Piisola, Antti,Syam Krishnan,Pihko, Petri M.
supporting information; experimental part, p. 1682 - 1694 (2011/05/04)
The synthesis of the nonanomeric 10-epi-ABCDE ring system of pectenotoxin-2 has been achieved by using a kinetic spiroketalization reaction. The synthesis of the spiroketalization precursor was achieved through a cross-metathesis/ hydrogenation sequence.
Alternative protocol for oxidation in water: An effective epoxidation system promoted by the combination of Oxone and an amphiphilic ketone
Masuyama, Araki,Yamaguchi, Takashi,Abe, Manabu,Nojima, Masatomo
, p. 213 - 216 (2007/10/03)
Epoxidation of cyclooctene and other alkenes with Oxone was promoted effectively in an aqueous micellar solution of an amphiphilic ketone, which was easily derived from hepta(ethylene glycol) monodecyl ether.