17747-43-2

Basic information

• Product Name: 3-ACETOXYPYRIDINE
• Synonyms: 3-Pyridinol, acetate;3-Pyridinyl acetate;3-PYRIDYL ACETATE;3-ACETOXYPYRIDINE;Acetoxypyridine;3-Aceyoxy pyridine;3-ACETOXYPYRIDINE 99%;Acetic acid 3-pyridyl ester
• CAS NO: 17747-43-2
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• EINECS: 241-742-7
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Compounds
• Mol File: 17747-43-2.mol

Chemical Properties

• Boiling Point: 92 °C9 mm Hg(lit.)
• Flash Point: 213 °F
• Appearance: /
• Density: 1.141 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.125mmHg at 25°C
• Refractive Index: n20/D 1.503(lit.)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 3.76±0.10(Predicted)
• CAS DataBase Reference: 3-ACETOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETOXYPYRIDINE(17747-43-2)
• EPA Substance Registry System: 3-ACETOXYPYRIDINE(17747-43-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 17747-43-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Acetoxypyridine is used as a versatile intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and medicines due to its chemical reactivity and structural properties.
Used in Agrochemical Industry:
In agrochemicals, 3-Acetoxypyridine is utilized as a key intermediate, playing a crucial role in the production of pesticides and other agricultural chemicals to enhance crop protection and yield.
Used in Dye and Pigment Industry:
3-Acetoxypyridine is used as a precursor in the manufacturing of dyestuffs, where its chemical structure contributes to the color and stability of the dyes produced.
Used in Antioxidant Production:
As an intermediate in the production of antioxidants, 3-Acetoxypyridine helps in creating compounds that prevent oxidation in various applications, thus extending the shelf life and performance of products.
Used in Rubber Chemical Industry:
3-Acetoxypyridine is employed in the synthesis of rubber chemicals, enhancing the properties of rubber materials and contributing to the development of improved rubber products.
Used in Materials Science:
3-Acetoxypyridine has potential applications in materials science, particularly for the development of new polymers and materials with unique properties, such as enhanced strength, flexibility, or resistance to environmental factors.
However, due to its hazardous nature, 3-Acetoxypyridine requires careful handling to prevent irritation to the skin, eyes, and respiratory system, as well as to minimize potential adverse effects on human health and the environment.

InChI:InChI=1/C7H7NO2/c1-6(9)10-7-3-2-4-8-5-7/h2-5H,1H3

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 81211-94-1 C₉H₁₀N₂O₃ 
• 74-86-2 acetylene 
• 155164-63-9 2-acetyl-4,5-dichloropyridazin-3(2H)-one 
• 142-08-5 2-hydroxypyridin 
• 56000-40-9 2,4,6-Trimethyl-benzenesulfonate3-acetoxy-1-amino-pyridinium; 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 16197-93-6 (S)-1-phenylethyl acetate 
• 16197-92-5 (R)-1-phenethyl acetate 
• 56000-40-9 2,4,6-Trimethyl-benzenesulfonate3-acetoxy-1-amino-pyridinium; 
• 78-93-3 butanone 
• 111-13-7 hexyl-methyl-ketone 
• 105621-26-9 3-Acetoxy-4-benzyl-4H-pyridine-1-carboxylic acid methyl ester 
• 105621-27-0 3-Acetoxy-4-benzyl-4H-pyridine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 76509-17-6 3-benzyloxypyridine 
• 7295-76-3 3-methoxypyridine 
• 15128-91-3 3-hydroxy-2,6-dinitropyridine 
• 26372-53-2 N-(3-Hydroxy-2-pyridyl)-acetamid-acetat 
• 92609-05-7 (7R,8R)-7-Methyl-1-aza-tricyclo[4.4.0.0^2,8]dec-3-en-5-one 
• 109-00-2 3-HYDROXYPYRIDINE 
• 105462-24-6 risedronic acid 

Relevant articles and documents

COMPARISON OF ANALYTICAL PYROLYSIS TECHNIQUES IN THE CHARACTERIZATION OF CHITIN.

The results of various analytical pyrolysis techniques with on-line and off-line detection have been examined with respect to characteristicity and contents of information, using chitin as a model polymer. Curie-point pyrolysis-low-energy electron impact mass spectrometry (cPy-EIMS), using normal and preheated telescopic glass tube sample holders, was applied, as well as Curie-point pyrolysis-gas chromatography/mass spectrometry, with electron impact ionization and chemical ionization (cPy-GC/EIMS, cPy-GC/CIMS).

Spectroscopic and Crystallographic Characterization of the R3N+?C?H???X Interaction

As appreciation for nonclassical hydrogen bonds has progressively increased, so have efforts to characterize these interesting interactions. Whereas several kinds of C?H hydrogen bonds have been well-studied, much less is known about the R3Nsu

Preparation method of 2,3-dichloropyridine

The invention provides a preparation method of 2,3-dichloropyridine. The 2,3-dichloropyridine is prepared by a one-pot method, pyridine alkyl ester serves as a raw material, and synthesis is conductedby a mode of performing chlorination, performing hydrolysis and performing chlorination again; the chlorination is substitution reaction, substitution on a benzene ring is relatively easy, the alkylester group can protect the site of the first-time chlorination reaction to be at 2 position, the hydrolysis reaction is mild in condition and rapid in reaction compared with the prior art, the second-time chlorination is to substitute the hydroxyl, the reaction is easy and the reaction condition is relatively mild. The preparation method provided by the invention is simple in operation, few threewastes are generated in the production process, requirements on equipment are low and the yield is high.

Structures, Lewis Acidities, Electrophilicities, and Protecting Group Abilities of Phenylfluorenylium and Tritylium Ions

The isolation, characterization, and the first X-ray structures of a fluorenylium ion and its Lewis adducts with nitrogen- and phosphorus-centered Lewis bases are reported. Kinetics of the reactions of a series of fluorenylium ions with reference π-, σ-, and n-nucleophiles of various sizes and nucleophilicities allowed the interplay between electronic and structural parameters on the electrophilicities of these planarized tertiary carbenium ions to be elucidated. Structure–reactivity correlations and extensive comparisons of their reactivities with those of di- and triarylcarbenium ions are described. Quantitative determination of the electrofugalities of fluorenylium ions revealed to which extent they are complementing tritylium ions as protecting groups and how their tuning is possible. Determination of the equilibrium constants of the Lewis adducts formation between pyridines of calibrated Lewis basicities and phenylfluorenylium and tritylium ions allowed the determination of their Lewis acidities and to showcase the potential of these carbon-centered Lewis acids in catalysis.

Facile esterification of alcohols with 2-Acyl-4,5-dichloropyridazin-3(2 H)-ones under Friedel-Crafts conditions

This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel-Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel-Crafts conditions, representing a rapid, practical, and efficient method of esterification. Georg Thieme Verlag Stuttgart. New York.

Catalyst-free esterification of alcohols using 2-acyl-4,5- dichloropyridazinones under microwave conditions

Efficient and green esterification is of great importance. In this work, we demonstrate the catalyst-free esterification of alcohols by their reaction with 2-acyl-4,5-dichloropyridazin-3(2H)-ones under microwave irradiation. Aliphatic and aromatic alcohols were converted into the corresponding esters in good to excellent yields under microwave irradiation in solvent or solvent-free conditions. It is noteworthy that the reaction is catalyst-free, atom-economic, and rapid and that the process is inexpensive.

Rapid and Ecofriendly Esterification of Alcohols with 2-Acylpyridazinones

Atom-economical esterification is of great importance in green chemistry. In this work, we demonstrated the catalyst and additive free esterification of alcohols by their reaction with 2-acyl-4,5-dichloropyridazin-3(2H)- ones without solvent at 100 oC. Aliphatic and aromatic alcohols were converted into the corresponding esters in good to excellent yields. It is noteworthy that the reaction is solvent-free, atom-economic, easy-workup, and rapid and that the process is inexpensive.

Heterogeneous Baeyer-Villiger oxidation of ketones with H2O2/nitrile, using Mg/Al hydrotalcite as catalyst

We synthesized a magnesium-aluminium hydrotalcite and used it as a catalyst in the Baeyer-Villiger (BV) oxidation of cyclohexanone with a mixture of 30% aqueous hydrogen peroxide and benzonitrile as oxidant. The hydrotalcite proved an excellent catalyst for the process. The influence of experimental variables was examined in depth in order to bring the working conditions as close as possible to those usable on an industrial scale. We optimized the cyclohexanone/hydrogen peroxide/benzonitrile proportion and used various nitriles, solvents and amounts of catalyst, benzonitrile and methanol proving the most effective nitrile and solvent, respectively, for the intended purpose. The reaction was found to occur to an acceptable extent with other carbonyl compounds as substrates; by exception, α,β-unsaturated carbonyl compounds provided poor results by effect of their undergoing competitive epoxidation of their double bonds.

SnCl4-promoted ethenylation reaction of hydroxylated heteroarenes

Reaction of hydroxylated heteroarenes and acetylene in the presence of SnCl4 and Bu3N (or Et3N) gives the corresponding ethenylated arenes. The reaction takes place at the neighboring position of the hydroxy group, and is applicable to quinolines, an isoquinoline, pyridines, and N-trifluoromethanesulfonylated indoles provided that the optimized conditions for the ethenylation and workup are employed.

Synthesis of alkyl heteryl ethers from acetates under interphase catalysis conditions in a liquid/solid system

The reaction of acetates of heterocyclic alcohols with alkyl halides in the two-phase catalytic system of solid KOH/C6H6/18-crown-6 at room temperature leads selectively to the formation of the corresponding heterocyclic ethers in 32-93% yield. 1998 Plenum Publishing Corporation.