1780-40-1

Basic information

• Product Name: 2,4,5,6-Tetrachloropyrimidine
• Synonyms: 2,4,5,6-tetrachloro-pyrimidin;perchloropyrimidine;tetrachloro-pyrimidin;tetrachloropyrimidine;2,4,5,6-TETRACHLOROPYRIMIDINE;Tetrachlorpyrimidin;2,4,5,6-Tetrachloropyrimidine,97%;2,4,5,6-TetrachloropyriMidine, 97% 5GR
• CAS NO: 1780-40-1
• Molecular Formula: C₄Cl₄N₂
• Molecular Weight: 217.87
• EINECS: 217-228-3
• Product Categories: FINE Chemical & INTERMEDIATES;pharmacetical;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 1780-40-1.mol

Chemical Properties

• Melting Point: 68-70 °C(lit.)
• Boiling Point: 108 °C
• Flash Point: 133.2 °C
• Appearance: White/Crystalline Powder
• Density: 1.7673 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -8.56±0.39(Predicted)
• CAS DataBase Reference: 2,4,5,6-Tetrachloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5,6-Tetrachloropyrimidine(1780-40-1)
• EPA Substance Registry System: 2,4,5,6-Tetrachloropyrimidine(1780-40-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-27-37/39-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UV9745000
• Hazardous Substances Data: 1780-40-1(Hazardous Substances Data)

Usage

Chemical Properties

Beige crystals and chunks

InChI:InChI=1/C4Cl4N2/c5-1-2(6)9-4(8)10-3(1)7

Upstream product

• 67-52-7 BARBITURIC ACID 
• 61066-33-9 pyrimidine-2,4,5,6(1H,3H)-tetraone 
• 444-15-5 5-hydroxybarbituric acid 
• 10026-13-8 phosphorus pentachloride 
• 10025-87-3 trichlorophosphate 
• 21428-20-6 5,6-dichloro-1H-pyrimidine-2,4-dione 
• 106351-49-9 dilituric acid 
• 1738-25-6 3-dimethylaminopropiononitrile 

Downstream Products

• 289-95-2 PYRIMIDINE 
• 115581-46-9 2-benzilamino-4,5,6-tricloropirimidina 
• 115581-47-0 4-benzilamino-2,5,6-tricloropirimidina 
• 28969-60-0 4-amino-2,5,6-trichloropyrimidine 
• 319-87-9 pentachlorofluorobenzene 
• 767-79-3 2,4,5,6-tetrafluoropyrimidine 
• 697-83-6 2,4,6-trifluoro-5-chloropyrimidine 
• 90845-52-6 4-(4-nitrophenylamino)-2,5,6-trichloropyrimidine 
• 1002352-28-4 2,4,5-trichloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidine 
• 1239984-50-9 C₁₀H₄Cl₃FN₂ 
• 1239984-31-6 C₄₀H₂₇ClN₂ 
• 1239984-21-4 C₅₂H₃₆N₂ 
• 1239984-09-8 C₃₂H₂₈N₂ 
• 1239984-39-4 C₁₈H₁₄Cl₂N₂ 

Relevant articles and documents

9- (PYRAZOL- 3 -YL) - 9H- PURINE-2 -AMINE AND 3- (PYRAZ0L-3-YL) -3H-IMIDAZ0 [4, 5-B] PYRIDIN-5-AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.

Method of preparing 4,5,6-trichloro-and 2,4,5,6-tetrachloropyrimidine

Crystals with an average crystal size of ≦10 μm comprising compounds of the formula Ia and/or IIa A process for making said crystals.

Method of preparing 4,5,6-trichloro- and 2,4,5,6-tetrachloropyrimidine

PCT No. PCT/EP97/02933 Sec. 371 Date Dec. 7, 1998 Sec. 102(e) Date Dec. 7, 1998 PCT Filed Jun. 6, 1997 PCT Pub. No. WO97/47605 PCT Pub. Date Dec. 18, 1997The invention relates to a process for the preparation of 4,5,6-trichloro- and 2,4,5,6-tetrachloropyr

Process for producing 2,4,5,6-tetrachloropyrimidine by way of 5,6-dichloro-2,4-dihydroxypyrimidine which was produced from the corresponding 5,6-dichloro-2,4-di(trihalomethyl)-pyrimidine and a process for producing 2,4-dihydroxypyrimidine derivatives

2,4-Dihydroxypyrimidines of the formula STR1 with the substituent meanings given in the description, are obtained by reacting pyrimidines of the formula STR2 with the substituent meanings given in the description, with aqueous alkalis at elevated temperature. 2,4,5,6-Tetrachloropyrimidine is obtained from the dihydroxypyrimidines by reaction with agents which replace hydroxyl by chlorine.

Process for the preparation of tetrachloropyrimidine

Process for the preparation of tetrachloropyrimidine, characterized in that 2-cyanoethyl isocyanide dichloride is reacted with chlorine in the gas phase in the temperature range from 200°-650° C.

Process for the preparation of tetrachloropyrimidine

Process for the preparation of tetrachloropyrimidine, characterized in that compounds of the formula STR1 wherein R = a radical which can be split off under the reaction conditions, Are reacted with chlorine or agents which release chlorine, preferably at

Process for the preparation of tetrachloropyrimidine

Process for the preparation of tetrachloropyrimidine, characterized in that compounds of the formula STR1 wherein R = a radical which can be split off under the reaction conditions and R' = optionally substituted lower allyl radical, are reacted with chlo