17896-21-8

Basic information

• Product Name: Citiolone
• Synonyms: DL-N-ACETYLHOMOCYSTEINETHIOLACTINE;citicoline diphosphate choline;cdpc;DL-N-ACETYLHOMOCYSTEINETHIOLACTONE/2-ACETAMIDO-4-MERCAPTOBUTYRICACIDG-THIOLACTONE;DL-N-Acetylhomocysteine thiolactone,99%;2-Acetamido-4-mercaptobutyric acid gamma-thiolactone;DL-N-AcetylhoMocysteine thiolactone, 99% 25GR;N-(2-Oxotetrahydrothiophen-3-yl)acetaMide
• CAS NO: 17896-21-8
• Molecular Formula: C6H9NO2S
• Molecular Weight: 159.21
• EINECS: 214-793-8
• Product Categories: Amino Acids
• Mol File: 17896-21-8.mol

Chemical Properties

• Melting Point: 109-111 °C
• Boiling Point: 427.3°C at 760 mmHg
• Flash Point: 212.2°C
• Appearance: White to off-white/Crystalline Powder
• Density: 1.202 (estimate)
• Vapor Pressure: 1.66E-07mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: -20°C
• CAS DataBase Reference: Citiolone(CAS DataBase Reference)
• NIST Chemistry Reference: Citiolone(17896-21-8)
• EPA Substance Registry System: Citiolone(17896-21-8)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 22-24/25-45
• WGK Germany: 3
• RTECS: AC8680000
• Hazardous Substances Data: 17896-21-8(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystalline powder

InChI:InChI=1/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)/t5-/m0/s1

Upstream product

• 563-63-3 silver(I) acetate 
• 6038-19-3 3-aminodihydrothiophen-2(3H)-one hydrochloride 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 51524-71-1 2,2-dichloro-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-acetamide 
• 7540-67-2 O-acetyl-L-homoserine 
• 10387-40-3 potassium thioacetate 
• 2185-02-6 L-homoserine lactone 
• 2185-03-7 L-homoserine lactone hydrochloride 

Downstream Products

• 152420-81-0 5-Chloro-3-formyl-thieno<2,3-b>pyridine 
• 57271-88-2 N-acetyl-rac-ethionine 
• 6038-19-3 3-aminodihydrothiophen-2(3H)-one hydrochloride 

Relevant articles and documents

Preparation Method for Homocystein Thiolactone or Selenolactone

The present invention provides an expensive reagent such as homocysteine thiolactone or selenolactone as the main intermediate of erdosteine, or an expensive reagent such as HI. More specifically, A) a homoserine lactone or N - protected homoserine is reacted with a thiocarboxylic acid metal salt or selenocarboxylic acid metal salt (RCOXM, X=S or Se). B) Step A) of producing homocysteine thiolactone or homocysteine sonoactone by deprotection of N - protected homocysteine thiolactone or N - protected homocysteine seleactone. The present invention relates to a method for producing homocysteine thiactone or homocysteine senolactone or a salt thereof by the following reaction scheme. [Reaction Scheme] Then, this time. X Is S or Se, R and R ' are independently alkyl or aryl which is C1 - C6, and M is Na or K.

Syntheses of Sequence-Controlled Polymers via Consecutive Multicomponent Reactions

Multicomponent reactions have recently attracted a great deal of attention as they are considered as a powerful tool for constructing sequence-controlled polymers. Although new examples are constantly flourishing in the literature, the process that allows two or more consecutive multicomponent-reactions to react in a single operation for the syntheses of sequence-controlled polymers has not been developed until now. Here, we propose a new strategy combining multicomponent reaction of amine, thiol, and alkene conjugating and multicomponent polymerization of diyne, azide, and diamine coupling in one-pot for the synthesis of sequence-controlled polymer.

Two tandem multicomponent reactions for the synthesis of sequence-defined polymers

Multicomponent polymerizations have become powerful tools for the construction of sequence-defined polymers. Although the Passerini multicomponent reaction has been widely used in the synthesis of sequence-defined polymers, the tandem usage of the Passerini multicomponent reaction and other multicomponent reactions in one-pot for the synthesis of sequence-defined polymers has not been developed until now. In this contribution, we report the tandem usage of the Passerini three-component reaction and the three-component amine-thiol-ene conjugation reaction in one pot for the synthesis of sequence-defined polymers. The Passerini reaction between methacrylic acid, adipaldehyde, and 2-isocyanobutanoate was carried out, affording a new molecule containing two alkene units. Subsequently, an amine and a thiolactone were added to the reaction system, whereupon the three-component amine-thiol-ene conjugating reaction occurred to yield a sequence-defined polymer. This method offers more rapid access to sequence-defined polymers with high molecular diversity and complexity.

MANUFACTURING METHOD OF N-ACYL-α-AMINOLACTONE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for manufacturing an N-acyl-α-aminolactone compound in a high yield and a high purity from an acid salt of α-aminolactone. SOLUTION: The provided method for manufacturing an N-acyl-α-aminolactone compound is a method for manufacturing a specified N-acyl-α-aminolactone compound by reacting, in the presence of a solvent and a basic compound, an acid salt of a specified α-aminolactone and an anhydrous fatty acid. The reaction is carried out in the presence of a weak-basic compound at a quantitative ratio of 0.7 or more molar equivalent and 5 or less molar equivalent with respect to 1 mole of the acid salt of the α-aminolactone. The number of carbon atoms of the anhydrous fatty acid is 4 or more and 12 or less. The solvent is a solvent having solubilities, with the α-aminolactone and weak-basic compound (25°C), of 1 g or less each and a solubility, with the anhydrous fatty acid (25°C), of 10 g or more and is at least one type selected from among ketone-based solvents, ether-based solvents, ester-based solvents, and halogen-based solvents. COPYRIGHT: (C)2015,JPOandINPIT

Synthesis of sequence-ordered polymers via sequential addition of monomers in one pot

Sequence-ordered polymers can be simply prepared in one pot via sequential monomer addition.