179388-73-9Relevant articles and documents
Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice
Dutta, Rinku,Kumar, Virender,Peng, Yang,Evande, Ruby E.,Grem, Jean L.,Mahato, Ram I.
, p. 564 - 578 (2017)
Purposes: To determine the pharmacokinetic parameters and biodistribution of GDC-0449 loaded polymeric micelles after systemic administration into common bile duct ligation (CBDL) induced liver fibrotic mice. Methods: We used GDC-0449 encapsulated methoxy
Tagging alcohols with cyclic carbonate: A versatile equivalent of (meth)acrylate for ring-opening polymerization
Pratt, Russell C.,Nederberg, Fredrik,Waymouth, Robert M.,Hedrick, James L.
, p. 114 - 116 (2008)
Cyclic carbonate monomers based on a single biocompatible scaffold allow for incorporation of a wide range of functional groups into macromolecules via ring-opening polymerization. The Royal Society of Chemistry.
Synthesis and liquid crystal behavior of new side chain aliphatic polycarbonates based on cholesterol
Liu, Xiaofeng,Guo, Zhihao,Xie, Yujiao,Chen, Zhangpei,Hu, Jianshe,Yang, Liqun
, p. 350 - 358 (2018)
In this study, we synthesized a series of new liquid crystal aliphatic block polycarbonates copolymers mPEG43-b-P(MCC-Cn)51 (n = 1–4) via the ring-opening polymerization, hydrogenation reduction and coupling reaction, which contained side functionalized cholesteryl groups and were different in the number of the flexible methylene groups. The chemical structures of the chiral compounds and copolymers obtained in this study were characterized by FT-IR and 1H NMR spectra, and the average molecular weights of the copolymers were investigated by average molecular weights gel permeation chromatographic (GPC). The polarizing optical microscopy (POM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to characterize the liquid crystal behavior. The relationship of the structure and phase behavior of the chiral compounds and copolymers influenced by spacer lengths was discussed. As a result, the chiral compounds with two methylene only showed a smectic A (SmA) phase, while those with more methylene showed a SmA phase and cholesteric phase. As the number of the flexible methylene groups increased, the corresponding melting temperature, the transition temperatures of LC phases and the isotropic temperature of chiral compounds all showed a decreasing trend, and mesophase temperature range narrowed. The polycarbonate copolymer with two methylene did not show mesomorphism, while the copolymers with longer spacer length seemed beneficial for the formation of mesophases at room temperature and revealed a smectic A phase with an interdigitated molecular arrangement on heating and cooling cycles. The results showed a decreased tendency toward the glass temperature, and an increased tendency toward isotropic temperature for the LC copolymers with an increase of the spacer length.
Self-assembling, amphiphilic polymer-gemcitabine conjugate shows enhanced antitumor efficacy against human pancreatic adenocarcinoma
Chitkara, Deepak,Mittal, Anupama,Behrman, Stephan W.,Kumar, Neeraj,Mahato, Ram I.
, p. 1161 - 1173 (2013)
The therapeutic efficacy of gemcitabine is severely compromised due to its rapid plasma metabolism. Moreover, its hydrophilicity poses a challenge for its efficient entrapment in nanosized delivery systems and to provide a sustained release profile. In th
Enteric Polymer Based on pH-Responsive Aliphatic Polycarbonate Functionalized with Vitamin E To Facilitate Oral Delivery of Tacrolimus
Wang, Menglin,Sun, Jin,Zhai, Yinglei,Lian, He,Luo, Cong,Li, Lin,Du, Yuqian,Zhang, Dong,Ding, Wenya,Qiu, Shuhong,Liu, Yuhai,Kou, Longfa,Han, Xiangfei,Xiang, Rongwu,Wang, Yongjun,He, Zhonggui
, p. 1179 - 1190 (2015)
(Figure Presented) To improve the bioavailability of orally administered drugs, we synthesized a pH-sensitive polymer (poly(ethylene glycol)-poly(2-methyl-2-carboxyl-propylene carbonate)-vitamin E, mPEG-PCC-VE) attempting to integrate the advantages of enteric coating and P-glycoprotein (P-gp) inhibition. The aliphatic polycarbonate chain was functionalized with carboxyl groups and vitamin E via postpolymerization modification. Optimized by comparison and central composite design, mPEG113-PCC32-VE4 exhibited low critical micelle concentration of 1.7 × 10-6 mg/mL and high drug loading ability for tacrolimus (21.2% ± 2.7%, w/w). The pH-responsive profile was demonstrated by pH-dependent swelling and in vitro drug release. Less than 4.0% tacrolimus was released under simulated gastric fluid after 2.5 h, whereas an immediate release was observed under simulated intestinal fluid. The mPEG113-PCC32-VE4 micelles significantly increased the absorption of P-gp substrate tacrolimus in the whole intestine. The oral bioavailability of tacrolimus micelles was 6-fold higher than that of tacrolimus solution in rats. This enteric polymer therefore has the potential to become a useful nanoscale carrier for oral delivery of drugs.
Degradation behavior of poly(lactide-co-carbonate)s controlled by chain sequences
Liu, Xinli,Cui, Dongmei,Hua, Xiufang
, p. 5289 - 5296 (2020)
Immortal copolymerization of lactide (LA) and 2-methyl-2-benzyloxycarbonyl-1,3-trimethylene carbonate (MBC) affords random, tapered, and diblock microstructured poly(lactide-co-carbonate)s. Subsequent debenzylation of these poly(LA-co- MBC)s by Pd/C catalytic hydrogenation gives poly(LA-co-MCC)s containing carboxylic acid, which show controlled degradation performance during in vitro hydrolytic degradation experiments. The degradation rates of poly(LA-co-MCC)s are proved for the first time to be affected significantly by lactide-carbonate linkages in the main chains, following the trend of lactide-carbonate unit (L- C/C-L)>carbonate-carbonate unit (C-C)>lactide-lactide unit (L-L). The resultant hydrolysis products are the precursors for synthesizing the corresponding monomers. Therefore, the degradable and recyclable materials are accomplished.
Synthesis and characterization of hyperbranched poly(ε-caprolactone)s having different lengths of homologous backbone segments
Choi, Jeongsoo,Kwak, Seung-Yeop
, p. 8630 - 8637 (2003)
Hyperbranched poly(ε-caprolactone)s (HPCLs) were synthesized by moisture-sensitive catalyst-free polycondensation of AB2 macromonomers, 2,2-bis[ω-hydroxy oligo(ε-caprolactone)methyl]-propionic acids. The HPCLs were designed to incorporate diffe
Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria
Nimmagadda, Alekhya,Liu, Xuan,Teng, Peng,Su, Ma,Li, Yaqiong,Qiao, Qiao,Khadka, Nawal K.,Sun, Xiaoting,Pan, Jianjun,Xu, Hai,Li, Qi,Cai, Jianfeng
, p. 87 - 95 (2017)
The resistance developed by life-threatening bacteria toward conventional antibiotics has become a major concern in public health. To combat antibiotic resistance, there has been a significant interest in the development of antimicrobial cationic polymers
Cholesterol and Morpholine Grafted Cationic Amphiphilic Copolymers for miRNA-34a Delivery
Sharma, Saurabh,Mazumdar, Samrat,Italiya, Kishan S.,Date, Tushar,Mahato, Ram I.,Mittal, Anupama,Chitkara, Deepak
, p. 2391 - 2402 (2018)
miR-34a is a master tumor suppressor playing a key role in the several signaling mechanisms involved in cancer. However, its delivery to the cancer cells is the bottleneck in its clinical translation. Herein we report cationic amphiphilic copolymers graft
EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer
Mondal, Goutam,Kumar, Virender,Shukla, Surendra K.,Singh, Pankaj K.,Mahato, Ram I.
, p. 301 - 313 (2016)
The objective of this study was to design GE11 peptide (YHWYGYTPQNVI) linked micelles of poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-gemcitabine-graft-dodecanol (PEG-b-PCC-g-GEM-g-DC) for enhanced stability and target sp
