179555-10-3

Basic information

• Product Name: 2-AMINO-5-CYANO-4-PICOLINE
• Synonyms: 6-Amino-4-methylnicotinonitrile;2-Amino-5-cyano-4-picoline, 6-Amino-4-methylpyridine-3-carbonitrile;2-AMino-5-cyano-4-Methylpyridine;6-amino-4-methyl-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-amino-4-methyl-;2-AMINO-5-CYANO-4-PICOLINE;3-Pyridinecarbonitrile,6-amino-4-methyl-(9CI);6-amino-4-methylpyridine-3-carbonitrile
• CAS NO: 179555-10-3
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• Product Categories: PYRIDINE
• Mol File: 179555-10-3.mol

Chemical Properties

• Boiling Point: 318.514 °C at 760 mmHg
• Flash Point: 146.432 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.10±0.24(Predicted)
• CAS DataBase Reference: 2-AMINO-5-CYANO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CYANO-4-PICOLINE(179555-10-3)
• EPA Substance Registry System: 2-AMINO-5-CYANO-4-PICOLINE(179555-10-3)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 179555-10-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5-cyano-4-picoline is used as a chemical intermediate for the development of pharmaceutical compounds. Its ability to coordinate metal ions makes it a valuable component in the synthesis of coordination complexes that can have medicinal applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-5-cyano-4-picoline serves as a precursor in the production of various agrochemicals. Its role in forming heterocyclic compounds contributes to the development of new pesticides or other agrochemical products.
Used in Dye Production:
2-Amino-5-cyano-4-picoline is used as a building block in the synthesis of dyes. Its involvement in creating heterocyclic compounds lends itself to the production of a range of dyes used in different industries, including textiles and printing.
Used in Coordination Chemistry:
2-Amino-5-cyano-4-picoline is utilized as a ligand in coordination chemistry. It is instrumental in the formation of coordination complexes, which have applications in areas such as catalysis, materials science, and supramolecular chemistry.

InChI:InChI=1/C7H7N3/c1-5-2-7(9)10-4-6(5)3-8/h2,4H,1H3,(H2,9,10)

Upstream product

• 98198-48-2 2-amino-5-bromo-4-methylpyridine 
• 544-92-3 copper(I) cyanide 
• 557-21-1 zinc(II) cyanide 
• 107-15-3 ethylenediamine 

Downstream Products

• 1312556-65-2 7-methylimidazo[1,2-a]pyridine-6-carboxylic acid 
• 1224465-02-4 5-methoxycarbonyl-4-methyl-2-hydroxypyridine 
• 66909-35-1 6-chloro-4-methylpyridine-3-carbonitrile 
• 720660-12-8 5-(aminomethyl)-4-methylpyridin-2-amine 

Relevant articles and documents

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of the formula (I) wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects, nematodes, molluscs or representatives of the order Acarina.

Synthesis of a series of iridium complexes bearing substituted 2-pyridonates and their catalytic performance for acceptorless dehydrogenation of alcohols under neutral conditions

A series of Cp*Ir complexes bearing 5- and 4,5-substituted 2-pyridonate ligands have been synthesized and their catalytic performance for acceptorless dehydrogenation of alcohols has been investigated under neutral conditions. Electron-withdrawing groups such as methoxycarbonyl, trifluoromethyl, cyano, and nitro groups at the 5-position promoted the acceptorless dehydrogenation of 1-phenylethanol, whereas electron-donating methyl group at the 5-position retarded the reaction. Furthermore, introduction of methyl group at the 4-position improved the catalytic performance. Thus, Cp*Ir(5-trifluoromethyl-4-methyl-2-pyridonate)Cl (2bc) exhibited the highest catalytic performance among the complexes examined, and also showed good catalytic performance for acceptorless dehydrogenation of primary alcohols.

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists

A series of 6-aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA A receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABAAR binding affinities to native GABAA receptors (Ki 1.1-24 μM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K i 0.044 μM) and equipotency as an agonist to GABA itself as well as the standard GABAA agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a α1β 2γ2 GABAA receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABAAR agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABAAR area.

4-ARYL-BUTANE-1,3-DIAMIDES

The invention relates to compound of the formula (I): in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES

The invention relates to compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Substituted 2-aminopyridines as inhibitors of nitric oxide synthase

Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. STR1