180305-85-5

Basic information

• Product Name: (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE
• Synonyms: (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE;(R)-a-Phenyl-1-pyrrolidineethanaMine 2HCl
• CAS NO: 180305-85-5
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.288
• Mol File: 180305-85-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE(180305-85-5)
• EPA Substance Registry System: (R)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE(180305-85-5)

Safety Data

• Hazardous Substances Data: 180305-85-5(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
(R)-PPA is used as a research chemical for studying the effects of psychoactive substances on the human brain, particularly their interactions with neurotransmitters like dopamine, norepinephrine, and serotonin.
Used in Recreational Drug Use:
(R)-PPA is used as a recreational drug for its stimulant and psychoactive effects, although its use is not recommended due to the associated health risks and side effects.

Upstream product

• 123-75-1 pyrrolidine 
• 20780-53-4 (R)-Styrene oxide 
• 136329-29-8 (R)-1-pyrrolidine 
• 17609-52-8 Z-D-phenylglycine 
• 180305-84-4 (S)-2-(Pyrrolidin-1-yl)-2-phenylethanol 
• 20989-17-7 (2S)-2-phenylglycinol 
• 190442-37-6 (R)‐2‐amino‐2‐phenyl‐1‐(pyrrolidin‐1‐yl)ethan‐1‐one 

Downstream Products

• 1039631-74-7 N-(tert-butoxycarbonyl)-3-(S)-(1-(R)-phenyl-2-N'-pyrrolidinylethyl)aminopyrrolidine 

Relevant articles and documents

Synthesis and application of L-proline and R-phenylglycine derived organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

Novel R-phenylglycine derived organocatalysts were prepared from the reaction of Cbz-R-phenylglycine with indoline, pyrrolidine, or (S)-(-)-2-(diphenylmethyl)pyrrolidine in 3 steps. The asymmetric Michael addition of cyclohexanone to nitroolefins was investigated using R-phenylglycine derivatives along with L-prolinamides as chiral catalysts. The desired products were obtained in excellent yields with enantioselectivities up to 90% ee and diastereomeric ratio up to 98:2 of the syn addition product. TUeBITAK, 2012.

DPP-IV INHIBITORS

The invention relates to compounds of formula (I), Z-C(R1R 2)-C(R3NH2)-C(R4R5)-X-N(R 6R7), wherein Z, R1-7 and X have the meaning as cited in the description and the claims. Said compounds are useful as DPP-lV inhibitors. The invention also relates to the

Two expedient methods for the preparation of chiral diamines

A study on the development of methodology for the synthesis of chiral diamines is reported. Two synthetic approaches are described both of which involve the generation and subsequent reaction of aziridinium ions. One of the methods is a one-pot preparatio

Design, synthesis, and application of chiral nonracemic lithium amide bases in enantioselective deprotonation of epoxides

The reaction of epoxides with chiral nonracemic lithium amide bases, designed and prepared from (R)-phenylglycine, has been studied in detail. A maximum of 80% ee was obtained for conversion of cyclohexene oxide to (S)-2-cyclohexen-1-ol. Enantioselective deprotonation of a variety of other epoxides was studied. A cyclopentanoid core unit for prostaglandin synthesis was synthesized in 97% ee.

A simple and efficient method for the preparation of homochiral amines: Application to the synthesis of a new C2 symmetric triamine

Using a one-pot reaction, (R)-styrene oxide has been converted into a variety of novel diamines and a C2 symmetric triamine. Yields range from 63-93%. The method is simple, efficient and is considerably shorter than other synthetic approaches.