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1-(3,5-difluorophenyl)piperazine is a chemical compound consisting of a piperazine ring with a 3,5-difluorophenyl group attached to it. It is known for its potential psychoactive properties and is a key building block in the synthesis of various pharmaceutical compounds, particularly those targeting the central nervous system.

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  • 180698-14-0 Structure
  • Basic information

    1. Product Name: 1-(3,5-difluorophenyl)piperazine
    2. Synonyms: 1-(3,5-difluorophenyl)piperazine
    3. CAS NO:180698-14-0
    4. Molecular Formula: C10H12F2N2
    5. Molecular Weight: 198.21
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 180698-14-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(3,5-difluorophenyl)piperazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(3,5-difluorophenyl)piperazine(180698-14-0)
    11. EPA Substance Registry System: 1-(3,5-difluorophenyl)piperazine(180698-14-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 180698-14-0(Hazardous Substances Data)

180698-14-0 Usage

Uses

Used in Pharmaceutical Industry:
1-(3,5-difluorophenyl)piperazine is used as a building block for the synthesis of pharmaceutical compounds, specifically for the development of central nervous system drugs. Its unique structure and properties make it a valuable component in creating new medications.
Used in Research and Development:
1-(3,5-difluorophenyl)piperazine is used as a subject of research in the development of new psychoactive substances. Its potential psychoactive properties have garnered interest in understanding its effects and applications in this field.
Used in Treatment of Neurological and Psychiatric Disorders:
1-(3,5-difluorophenyl)piperazine has been investigated for its potential use in the treatment of certain neurological and psychiatric disorders. Its involvement in the synthesis of drugs targeting the central nervous system makes it a promising candidate for further exploration and development in this area.

Check Digit Verification of cas no

The CAS Registry Mumber 180698-14-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,6,9 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 180698-14:
(8*1)+(7*8)+(6*0)+(5*6)+(4*9)+(3*8)+(2*1)+(1*4)=160
160 % 10 = 0
So 180698-14-0 is a valid CAS Registry Number.

180698-14-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3,5-Difluorophenyl)piperazine

1.2 Other means of identification

Product number -
Other names Piperazine,1-(3,5-difluorophenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:180698-14-0 SDS

180698-14-0Relevant articles and documents

LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME

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, (2021/04/17)

LpxH targeting compounds, compositions thereof, as well as methods for for making and using the same are disclosed herein. The LpxH target compounds typically have a structure pursuant to Formula (I) and/or a salt thereof, wherein Rb is selecte

Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors

Ennis, Amanda F.,Fenton, benjamin A.,Hong, Jiyong,Kwak, Seung-Hwa,Lim, Won Young,Webster, caroline G.,Zhou, Pei,cho, Jae,cochrane, c. Skyler

, (2020/07/13)

The UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH is essential in lipid A biosynthesis and has emerged as a promising target for the development of novel antibiotics against multidrug-resistant Gram-negative pathogens. Recently, we reported the c

INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE

-

, (2019/08/20)

Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic disorders, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.

PYRROLE mTORC INHIBITORS AND USES THEREOF

-

, (2020/01/12)

The present invention provides compounds, compositions thereof, and methods of using the same.

PYRROLE mTORC INHIBITORS AND USES THEREOF

-

, (2018/05/27)

The present invention provides compounds, compositions thereof, and methods of using the same.

TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

-

Page/Page column 119-120, (2010/07/10)

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.

ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS

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Page/Page column 68, (2010/11/23)

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Parallel synthesis of N-arylpiperazines using polymer-assisted reactions

Duncton, Matthew A. J.,Roffey, Jonathan R. A.,Hamlyn, Richard J.,Adams, David R.

, p. 2549 - 2552 (2007/10/03)

A series of N-arylpiperazines were prepared in a parallel fashion using palladium-catalyzed cross-coupling, or nucleophilic aromatic displacement chemistries, and polymer-assisted sequestration and purification techniques as key steps.

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.

Naito, Hiroyuki,Ohsuki, Satoru,Sugimori, Masamichi,Atsumi, Ryo,Minami, Megumi,Nakamura, Yoshihide,Ishii, Mineko,Hirotani, Kenji,Kumazawa, Eiji,Ejima, Akio

, p. 453 - 462 (2007/10/03)

A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propene (2) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines in vitro and antitumor activity against some tumor models when dosed both intraperitoneally and orally in vivo. Compounds 7a and 7e, the 3,5-difluorophenyl and 3,5-dichlorophenyl analogues of 2, respectively, showed significantly more potent cytotoxicity than 2 in vitro and potent antitumor activities without causing decrease of body temperature related to side effects.

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