18076-03-4

Basic information

• Product Name: 1-Methyl-3-phenyl-2-pyrazoline
• Synonyms: 1-Methyl-3-phenyl-2-pyrazoline;4,5-Dihydro-1-methyl-3-phenyl-1H-pyrazole
• CAS NO: 18076-03-4
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 0
• Mol File: 18076-03-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-3-phenyl-2-pyrazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-phenyl-2-pyrazoline(18076-03-4)
• EPA Substance Registry System: 1-Methyl-3-phenyl-2-pyrazoline(18076-03-4)

Safety Data

• Hazardous Substances Data: 18076-03-4(Hazardous Substances Data)

Upstream product

• 936-59-4 3-chloropropiophenone 
• 613-94-5 benzoic acid hydrazide 
• 768-60-5 4-methoxyphenylacetylen 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 1826-67-1 vinyl magnesium bromide 
• 60-34-4 methylhydrazine 
• 67-56-1 methanol 
• 861381-14-8 3-(methyl-nitroso-amino)-1-phenyl-propan-1-one 
• 64-19-7 acetic acid 
• 40178-28-7 1,1-dimethyl-1-phenacylhydrazinium bromide 
• 18076-00-1 1,1-dimethyl-3-phenyl-4,5-dihydro-1H-pyrazolium; iodide 

Downstream Products

• 18076-00-1 1,1-dimethyl-3-phenyl-4,5-dihydro-1H-pyrazolium; iodide 
• 3463-26-1 1-methyl-3-phenyl-1H-pyrazole 

Relevant articles and documents

Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C–C/C–N formation, annulation and aromatization with 1,2-dichloroethane

A novel route for tandem C–C/C–N formation, annulation and aromatization of hydrazones with 1,2-dichloroethane to synthesize 1H-pyrazoles has been developed. Furthermore, the 1,2-dichloroethane serves as alkylation reagent in good to excellent yields. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of 1H-pyrazoles.

Synthesis of 1-Aza-6,7-dehydrotropanes via Copper(I)-Catalyzed Coupling of 5-Chloropentan-2-one with Hydrazines and Terminal Alkynes

A one-pot, three-component, Cu(I)-catalyzed coupling of primary hydrazines, 5-chloropentan-2-one, and terminal alkynes was developed. The resulting 1-aza-6,7-dehydrotropanes compose a new class of substances while related 1-azatropanes are scarcely described in literature and closely resemble tropane alkaloids. Hydrogenation of the double bond in 1-aza-6,7-dehydrotropanes triggered a rearrangement, involving a [1,3]-hydride shift, forming cyclic hydrazones.

Thermolyses of 1,1-dimethyl-2-pyrazolinium fluoborates - Evidence for spiro--1-aza-1,4,6-octatrienyl cation

Thermolyses of 3-aryl-1,1-dimethyl-2-pyrazolinium fluoborates give an isomeric mixture of 3-aryl-1-methylpyrazole and 5-aryl-1-methylpyrazole as major products in complete contrast to the corresponding acyclic analogs. 2,6-Diaryl-3-methylpyridines were isolated only in trace quantities.The probable reasons for this unique behaviour was explored using semi-empirical calculations, non-kinetic methods and radiolabelling experiments.A pathway was proposed.

The Reaction of 1,1-Dimethyl-1-Phenacylhydrazinium Bromide with Aqueous Sodium Hydroxide

The reaction of 1,1-dimethyl-1-phenacylhydrazinium bromide with 1 M aqueous sodium hydroxide give benzoic acid, 3-phenyl-1-methylpyrazole, 5-benzoyl-3-phenyl-1-methylpyrazole, and benzonitrile as the major components; the expected product, 2-benzoyl-5-phenylimidazole was formed in only small amounts.Mechanisms to rationalize the formation of the major products are discussed.