- Pharmaceutical composition comprising almotriptan malate having uniform drug distribution and potency
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The present invention relates to tablets comprising almotriptan malate and mannitol, wherein the mannitol is in crystalline form and the bulk density of the mannitol is below 0.75 g/ml. The present invention also relates to a specific crystalline form of
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Paragraph 0107
(2014/09/29)
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- PROCESS FOR THE PREPARATION OF 1-[[[3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL]METHYL]SULFONYL] PYRROLIDINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
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The present invention relates to an improved process for the preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl] methyl] sulfonyl]pyrrolidine compound of formula- 1 and its pharmaceutically acceptable salts.
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Page/Page column 26
(2010/11/03)
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- NOVEL PROCESS
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The present invention relates to a novel process for the preparation of almotriptan and pharmaceutically acceptable salts thereof, which affords product conveniently and efficiently with commercially acceptable yields and purity. The present invention also relates to a novel synthetic intermediate used in the process.
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Page/Page column 13-15; 19-20
(2009/03/07)
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- METHOD FOR THE PREPARATION OF HIGH PURITY ALMOTRIPTAN
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A method for the preparation and purification of the substance of formula (I), i.e. 3-[2- (dimethylamino)ethyl]-5-(1-pyrrolidinylsulfonylmethyl)-1H-indole, which comprises (a) conversion of 4-(1-pyrrolidinylsulfonylmethyl)phenylhydrazine of formula (III) by reaction with an organic or inorganic acid to a salt that is insoluble or poorly soluble in water, which is converted to 3-(2-aminoethyl)-5-(1-pyrrolidinylsulfonylmethyl)indole of formula (VII), which is further converted without isolation to a solution of the almotriptan base, which provides a crystalline salt of almotriptan with an organic or inorganic acid; (b) conversion of the salt of almotriptan to the almotriptan base, which separates from the solution in the crystalline form; (c) purification of the almotriptan base by crystallization from an organic solvent.
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Page/Page column 4; 11-12
(2009/01/24)
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- Process for the Preparation of Almotriptan
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The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl) 1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydro
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Page/Page column 2-3
(2008/12/07)
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- Crystalline forms of almotriptan and processes for their preparation
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Crystalline forms of almotriptan and almotriptan malate are disclosed. Processes for their preparation and pharmaceutical compositions containing the same are also disclosed. The amorphous form of almotriptan malate, processes for its preparation and a pharmaceutical composition containing the same are also disclosed
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Page/Page column 7
(2008/06/13)
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- A PROCESS FOR THE PREPARATION OF ALMOTRIPTAN
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The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(l- Pyrrolidinyl sulfonyl methyl) lH-indol-yl] ethane amine ii) Treating crude Almotriptan with a hyd
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Page/Page column 6
(2010/11/25)
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