1821464-56-5

Basic information

• Product Name: Azide-PEG12-Tos
• Synonyms: Azide-PEG12-Tos
• CAS NO: 1821464-56-5
• Molecular Formula: C31H55N3O14S
• Molecular Weight: 725.8451
• Mol File: 1821464-56-5.mol

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Azide-PEG12-Tos(CAS DataBase Reference)
• NIST Chemistry Reference: Azide-PEG12-Tos(1821464-56-5)
• EPA Substance Registry System: Azide-PEG12-Tos(1821464-56-5)

Safety Data

• Hazardous Substances Data: 1821464-56-5(Hazardous Substances Data)

Usage

Uses

Used in Bioconjugation Applications:
Azide-PEG12-Tos is utilized as a bioconjugation agent for the attachment of biomolecules to various surfaces or nanoparticles. The azide group enables the formation of stable triazole linkages through Click Chemistry, allowing for precise and efficient conjugation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azide-PEG12-Tos serves as a component in drug delivery systems. Its ability to form stable triazole linkages through Click Chemistry allows for the development of targeted drug delivery vehicles, improving the therapeutic efficacy and reducing side effects.
Used in Materials Science:
Azide-PEG12-Tos is employed in materials science for the synthesis of functional polymers and coatings. The reagent's capacity to participate in Click Chemistry reactions facilitates the creation of advanced materials with tailored properties for specific applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, Azide-PEG12-Tos is used as a versatile building block. The tosyl group's role as a good leaving group in nucleophilic reactions makes it a valuable component in the synthesis of complex organic molecules.

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Relevant articles and documents

A Three-Arm Scaffold Carrying Affinity Molecules for Multiplex Recognition Imaging by Atomic Force Microscopy: The Synthesis, Attachment to Silicon Tips, and Detection of Proteins

We have developed a multiplex imaging method for detection of proteins using atomic force microscopy (AFM), which we call multiplex recognition imaging (mRI). AFM has been harnessed to identify protein using a tip functionalized with an affinity molecule

Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction

The antibody pretargeting approach for radioimmunotherapy (RIT) using inverse electron demand Diels-Alder cycloaddition (IEDDA) constitutes an emerging theranostic approach for solid cancers. However, IEDDA pretargeting has not reached clinical trial. The major limitation of the IEDDA strategy depends largely on trans-cyclooctene (TCO) stability. Indeed, TCO may isomerize into the more stable but unreactive cis-cyclooctene (CCO), leading to a drastic decrease of IEDDA efficiency. We have thus developed both efficient and reproducible synthetic pathways and analytical follow up for (PEGylated) TCO derivatives, providing high TCO isomeric purity for antibody modification. We have set up an original process to limit the isomerization of TCO to CCO before the mAbs’ functionalization to allow high TCO/tetrazine cycloaddition.

LINKER MOLECULE FOR MULTIPLEX RECOGNITION BY ATOMIC FORCE MICROSCOPY (AFM)

Some of the embodiments of the present disclosure relate to a compound of the formula, and methods of preparing and using same.