857892-34-3 Usage
$$\text{Structure
\underset\textOxygen chain\underbrace\text-O-(CH2-CH2-O)23- \underset\textAzide\underbrace\text-N3 \underset\textEster group\underbrace\text-O-SO3CH3$$
Functional Groups
Azide (-N3)
Ester (SO3CH3)
Number of Carbon Atoms in the Oxygen Chain
24 (23 oxygens)
Purpose/Use
Crosslinking agent in polymer chemistry
Crosslinking Mechanism
Azide functional group allows for easy attachment to other molecules, facilitating crosslinking.
Hydrophilic Properties
Due to the long oxygen chain.
Enhanced Solubility and Reactivity
Thanks to the 4-methylbenzenesulfonate group.
Applications
Production of polymeric materials
Development of advanced materials with tailored properties
Industrial Applications
Used in various industrial applications requiring tailored material properties.
Advantages
Facilitates crosslinking in polymer chemistry
Provides flexibility and hydrophilic properties
Enhances solubility and reactivity
Specific Role in Polymer Chemistry
Acts as a crosslinking agent to improve the mechanical properties and stability of polymers.
Versatility
Can be employed in diverse polymer formulations to achieve desired material characteristics.
Potential Drawbacks
Toxicity or environmental concerns associated with the azide group.
Cost considerations due to the synthesis process and raw materials.
Safety Precautions
Handle with appropriate protective measures due to the presence of azide.
Follow safety protocols for handling chemical reagents.
Regulatory Considerations
Compliance with regulations regarding the use and disposal of hazardous chemicals.
Research Trends
Exploration of modified derivatives for improved performance or reduced environmental impact.
Investigation into alternative crosslinking agents with enhanced safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 857892-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,7,8,9 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 857892-34:
(8*8)+(7*5)+(6*7)+(5*8)+(4*9)+(3*2)+(2*3)+(1*4)=233
233 % 10 = 3
So 857892-34-3 is a valid CAS Registry Number.
857892-34-3Relevant articles and documents
Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction
Béquignat, Jean-Baptiste,Boucheix, Claude,Canitrot, Damien,Chezal, Jean-Michel,Degoul, Fran?oise,Miot-Noirault, Elisabeth,Moreau, Emmanuel,Navarro-Teulon, Isabelle,Quintana, Mercedes,Rondon, Aurélie,Taiariol, Ludivine,Ty, Nancy
, (2020/07/21)
The antibody pretargeting approach for radioimmunotherapy (RIT) using inverse electron demand Diels-Alder cycloaddition (IEDDA) constitutes an emerging theranostic approach for solid cancers. However, IEDDA pretargeting has not reached clinical trial. The major limitation of the IEDDA strategy depends largely on trans-cyclooctene (TCO) stability. Indeed, TCO may isomerize into the more stable but unreactive cis-cyclooctene (CCO), leading to a drastic decrease of IEDDA efficiency. We have thus developed both efficient and reproducible synthetic pathways and analytical follow up for (PEGylated) TCO derivatives, providing high TCO isomeric purity for antibody modification. We have set up an original process to limit the isomerization of TCO to CCO before the mAbs’ functionalization to allow high TCO/tetrazine cycloaddition.
METHODS AND COMPOSITIONS FOR PROTEIN LABELLING
-
, (2010/09/07)
A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
