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182417-65-8

ETHYL 2-(6-CHLOROBENZO[D]THIAZOL-2-YL)ACETATE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 182417-65-8 Structure

  • Basic information

    1. Product Name: ETHYL 2-(6-CHLOROBENZO[D]THIAZOL-2-YL)ACETATE
    2. Synonyms: ETHYL 2-(6-CHLOROBENZO[D]THIAZOL-2-YL)ACETATE
    3. CAS NO:182417-65-8
    4. Molecular Formula: C11H10ClNO2S
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 182417-65-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ETHYL 2-(6-CHLOROBENZO[D]THIAZOL-2-YL)ACETATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: ETHYL 2-(6-CHLOROBENZO[D]THIAZOL-2-YL)ACETATE(182417-65-8)
    11. EPA Substance Registry System: ETHYL 2-(6-CHLOROBENZO[D]THIAZOL-2-YL)ACETATE(182417-65-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 182417-65-8(Hazardous Substances Data)

182417-65-8 Usage

Synthesis Reference(s)

Synthetic Communications, 26, p. 3535, 1996 DOI: 10.1080/00397919608003762

Check Digit Verification of cas no

The CAS Registry Mumber 182417-65-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,4,1 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 182417-65:
(8*1)+(7*8)+(6*2)+(5*4)+(4*1)+(3*7)+(2*6)+(1*5)=138
138 % 10 = 8
So 182417-65-8 is a valid CAS Registry Number.

182417-65-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-(6-chloro-1,3-benzothiazol-2-yl)acetate

1.2 Other means of identification

Product number -
Other names 6-CHLORO-2-BENZOTHIAZOLEACETIC ACID ETHYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:182417-65-8 SDS

182417-65-8Downstream Products

182417-65-8Relevant articles and documents

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction

Wang, Zhen,Zhang, Min,Wang, Jin,Ji, Haitao

supporting information, p. 3617 - 3635 (2019/03/29)

The β-catenin/T-cell factor (Tcf) protein-protein interaction (PPI) plays a critical role in the β-catenin signaling pathway which is hyperactivated in many cancers and fibroses. Based on compound 1, which was designed to target the Tcf4 G13ANDE17 binding site of β-catenin, extensive structure-activity relationship studies have been conducted. As a result, compounds 53 and 57 were found to disrupt the β-catenin/Tcf PPI with the Ki values of 0.64 and 0.44 μM, respectively, and exhibit good selectivity for β-catenin/Tcf over β-catenin/E-cadherin and β-catenin/adenomatous polyposis coli (APC) PPIs. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) cell viability assays revealed that 56, the ethyl ester of 53, was more potent than 53 in inhibiting viability of most of the Wnt/β-catenin hyperactive cancer cells. Further cell-based studies indicated that 56 disrupted the β-catenin/Tcf PPI without affecting the β-catenin/E-cadherin and β-catenin/APC PPIs, suppressed transactivation of Wnt/β-catenin signaling in dose-dependent manners, and inhibited migration and invasiveness of Wnt/β-catenin-dependent cancer cells.

Condensation of thioamides with 2-aminothiophenols: A versatile synthesis of benzothiazoles

Nivalkar, Kishor R.,Mashraqui, Sabir H.

, p. 3535 - 3542 (2007/10/03)

Thioamides condense with 2-aminothiophenols under convenient and mild conditions to provide a variety of simple and functionalized benzothiazoles in fair to good yields.

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