183429-63-2

Basic information

• Product Name: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE
• Synonyms: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE;Methyl 1-amino-1-cycloheptanecarboxylate HCl;Methyl 1-aMinocycloheptanecarboxylate;Cycloheptanecarboxylic acid, 1-amino-, methyl ester
• CAS NO: 183429-63-2
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.24
• Product Categories: pharmacetical
• Mol File: 183429-63-2.mol

Chemical Properties

• Boiling Point: 231.9 °C at 760 mmHg
• Flash Point: 98.6 °C
• Appearance: /
• Density: 1.02 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE(183429-63-2)
• EPA Substance Registry System: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE(183429-63-2)

Safety Data

• Hazardous Substances Data: 183429-63-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE is used as a building block for the synthesis of various compounds, including drugs, due to its unique structural features and reactivity in organic reactions. Its cycloheptane ring and functional groups contribute to the development of new drugs and pharmaceuticals with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE is employed as a key intermediate in the synthesis of bioactive molecules and drug candidates. Its structural properties allow for the creation of diverse chemical entities with potential therapeutic effects, making it a valuable component in drug discovery and development processes.

Upstream product

• 502-42-1 cycloheptanone 
• 67-56-1 methanol 
• 6949-77-5 1-aminocycloheptane-1-carboxylic acid 
• 123193-99-7 1-aminocycloheptanecarbonitrile 

Downstream Products

• 814254-62-1 (1-aminocycloheptyl)methanol 

Relevant articles and documents

Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds

A novel strategy to construct complex polycyclic nitrogen-containing heterocycles from aliphatic amines via picolinamide-assisted palladium-catalyzed C-H bond activation reaction was reported. The reaction exhibits broad substrate scope for the synthesis of various azabicyclic scaffolds, including azetidines and tropane-class alkaloids. Application of this method to naturally occurring (-)-cis-myrtanylamine, an unprecedented type of carbon-carbon bond activation, in which the electron-pair involved initiates an intramolecular "SN2-like" displacement of a cyclopalladium-fragment from a tertiary center, is described.

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups

Optimization of the amino acid residue within a series of anthranilimide-based glycogen phosphorylase inhibitors is described. These studies culminated in the identification of anthranilimides 16 and 22 which displayed potent in vitro inhibition of GPa in