METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE

Base Information

• Chemical Name: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE
• CAS No.: 183429-63-2
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.239
• Hs Code.: 2922499990
• Mol file: 183429-63-2.mol

Synonyms:Methyl 1-aminocycloheptanecarboxylate hydrochloride;

Chemical Property of METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE

Chemical Property:

• Boiling Point: 231.9 °C at 760 mmHg
• Flash Point: 98.6 °C
• PSA: 52.32000
• Density: 1.02 g/cm³
• LogP: 1.91140
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl1-Amino-1-cycloheptanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE

There total 4 articles about METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 1-aminocycloheptane-1-carboxylic acid (6949-77-5) → C9H17NO2 (183429-63-2)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acscombsci.6b00005

Reference yield:

cycloheptanone (502-42-1) → C9H17NO2 (183429-63-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium chloride; ammonium hydroxide / isopropyl alcohol / 20 °C / Inert atmosphere

2: hydrogenchloride; water / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

3: thionyl chloride / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; ammonium hydroxide; thionyl chloride; water; ammonium chloride; In 1,4-dioxane; isopropyl alcohol;

DOI:10.1021/acscombsci.6b00005

Reference yield:

1-aminocycloheptanecarbonitrile (123193-99-7) → C9H17NO2 (183429-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

2: thionyl chloride / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; water; In 1,4-dioxane;

DOI:10.1021/acscombsci.6b00005

upstream raw materials:

cycloheptanone

methanol

1-aminocycloheptane-1-carboxylic acid

1-aminocycloheptanecarbonitrile

Downstream raw materials:

(1-aminocycloheptyl)methanol

Refernces

• 1、 Stotani, Silvia,Lorenz, Christoph,Winkler, Matthias,Medda, Federico,Picazo, Edwige,Ortega Martinez, Raquel,Karawajczyk, Anna,Sanchez-Quesada, Jorge,Giordanetto, Fabrizio. "Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening". . p. 330 - 336. Retrieved 2016/07/06.