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184945-01-5

3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Benzoic acid, 3-[[[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4 -dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]amino]carbonyl]amino]-

    Cas No: 184945-01-5

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  • 184945-01-5 Structure

  • Basic information

    1. Product Name: 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid
    2. Synonyms: GW-7854
    3. CAS NO:184945-01-5
    4. Molecular Formula: C34H31N5O6
    5. Molecular Weight: 605.65607
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 184945-01-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid(184945-01-5)
    11. EPA Substance Registry System: 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid(184945-01-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 184945-01-5(Hazardous Substances Data)

184945-01-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 184945-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,9,4 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 184945-01:
(8*1)+(7*8)+(6*4)+(5*9)+(4*4)+(3*5)+(2*0)+(1*1)=165
165 % 10 = 5
So 184945-01-5 is a valid CAS Registry Number.

184945-01-5Downstream Products

184945-01-5Relevant articles and documents

Use of 1,5-benzo?b!1,4-diazepines to control gastric emptying

-

, (2008/06/13)

A method of controlling gastric emptying in patients having an early non-insulin-dependent diabetic condition and exhibiting rapid gastric emptying comprising the administration of an effective gastric emptying controlling amount of a compound of Formula

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent

Hirst, Gavin C.,Aquino, Christopher,Birkemo, Lawrence,Croom, Dallas K.,Dezube, Milana,Dougherty Jr., Robert W.,Ervin, Gregory N.,Grizzle, Mary K.,Henke, Brad,James, Michael K.,Johnson, Michael F.,Momtahen, Tanya,Queen, Kennedy L.,Sherrill, Ronald G.,Szewczyk, Jerzy,Willson, Timothy M.,Sugg, Elizabeth E.

, p. 5236 - 5245 (2007/10/03)

Analogs of the previously reported 1,5-benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonist 1 were prepared which explore substitution and/or replacement of the C-3 phenyl urea moiety. Agonist efficacy on the isolated guinea pig gallbladder (GPGB) was retained with a variety of substituted ureas and amide analogs. Three compounds were identified which were orally active in the mouse gallbladder emptying assay (MGBE). The 2-indolamide (52) and N-(carboxymethyl)-2-indolamide (54) derivatives had improved affinity for the human CCK-A receptor but reduced agonist efficacy on the GPGB. Neither indolamide was orally active in a rat feeding assay. In contrast, the (3-carboxyphenyl)urea derivative (29, GW7854) had moderately increased affinity for the human CCK-B receptor but was a potent full agonist on the GPGB and was orally active in both the MGBE and rat feeding assays. GW7854 was a full agonist (EC50 = 60 nM) for calcium mobilization on CHO K1 cells expressing hCCK-A receptors and a potent antagonist of CCK-8 (pA2 = 9.1) on CHO K1 cells expressing hCCK-B receptors. GW7854 is a potent mixed CCK-A agonist/CCK-B antagonist which is orally active in two in vivo models of CCK-A-mediated agonist activity.

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