- The design and synthesis of orally active short duration spiroindane growth hormone secretagogues
-
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally active secretagogues with a short duration of action.
- Tata, James R.,Lu, Zhijian,Jacks, Thomas M.,Schleim, Klaus D.,Cheng, Kang,Wei, Liente,Chan, Wanda W.-S,Butler, Bridget,Tsou, Nancy,Leung, Kwan,Chiu,Hickey, Gerard,Smith, Roy G.,Patchett, Arthur A.
-
-
Read Online
- Amido spiropiperidines promote the release of growth hormone
-
The present invention is directed to certain spiropiperidines of the general structural formula: wherein R1, R2, R3, R3a, R3b, R4and R5are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
- -
-
-