185854-45-9

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-2-QUINOLINEACETIC ACID
• Synonyms: 1,2,3,4-TETRAHYDRO-2-QUINOLINEACETIC ACID;RARECHEM AK ML 0239;(1,2,3,4-Tetrahydro-quinolin-2-yl)acetic acid
• CAS NO: 185854-45-9
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Product Categories: pharmacetical
• Mol File: 185854-45-9.mol

Chemical Properties

• Boiling Point: 407 °C at 760 mmHg
• Flash Point: 199.9 °C
• Appearance: /
• Density: 1.162 g/cm³
• Vapor Pressure: 2.35E-07mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-2-QUINOLINEACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-2-QUINOLINEACETIC ACID(185854-45-9)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-2-QUINOLINEACETIC ACID(185854-45-9)

Safety Data

• Hazardous Substances Data: 185854-45-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-2-quinolineacetic acid is used as a chemical intermediate for the synthesis of biologically active compounds and drug molecules, contributing to the development of new therapeutic agents.
Used in Monoamine Oxidase Inhibition:
1,2,3,4-Tetrahydro-2-quinolineacetic acid is used as an inhibitor of monoamine oxidase (MAO), an enzyme that plays a crucial role in the metabolism of neurotransmitters in the brain. Its inhibitory action on MAO may have implications for the treatment of various neurological and psychiatric disorders.
Used in Anti-inflammatory Applications:
1,2,3,4-Tetrahydro-2-quinolineacetic acid is used as an anti-inflammatory agent, potentially mitigating inflammation through its effects on biochemical pathways associated with inflammatory responses.
Used in Analgesic Applications:
1,2,3,4-Tetrahydro-2-quinolineacetic acid is used as an analgesic, which may help in alleviating pain by interacting with pain transmission pathways in the body.
Used in Anti-cancer Applications:
1,2,3,4-Tetrahydro-2-quinolineacetic acid is used as an anti-cancer agent, having been investigated for its potential to inhibit the growth and proliferation of cancer cells, making it a candidate for further research in oncology.

InChI:InChI=1/C11H13NO2/c13-11(14)7-9-6-5-8-3-1-2-4-10(8)12-9/h1-4,9,12H,5-7H2,(H,13,14)

Upstream product

• 150535-15-2 methyl 2-(1,2,3,4-tetrahydroquinolin-2-yl)acetate 
• 5100-75-4 (+/-)-2-Cyanomethyl-1,2,3,4-tetrahydroquinoline 
• 93-10-7 quinoline-2-carboxylic acid 
• 63430-96-6 1,2,3,4-tetrahydroquinolin-2-ylmethanol 
• 46185-24-4 1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 618113-62-5 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline 
• 91-63-4 2-methylquinoline 
• 1613-37-2 Quinoline N-oxide 
• 52249-48-6 quinoline-2-acetic acid methyl ester 
• 149755-78-2 Methyl-1,2-dihydro-2-chinolylidenacetoacetat 

Downstream Products

• 150533-87-2 6-bromo-5-<(methoxycarbonyl)methyl>-6,7-dihydro-1H,5H-pyrido<1,2,3-de>quinoxaline-2,3-dione 

Relevant articles and documents

Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β-Amino Acids

Electrophilic aminations involve an umpolung of a nitrogen atom, providing an alternate, distinctive synthetic strategy. The recent advent of various designed O-substituted hydroxylamines has significantly advanced this research field. An underappreciated

Benzocarbacephems from quinolines

The azetidinones 1,2 and 3 have been prepared from simple quinoline derivatives. 2,2a,3,4-Tetrahydro-1H-azeto[1,2-a]quinolin-1-one 1 has been synthesised from quinoline N-oxide and, more efficiently, in three steps from 2-methylquinoline. In both routes 1,2,3,4-tetrahydroquinoline-2-acetic acid 7 is prepared as an intermediate and this is then cyclised to the azetidinone 1. The 8-hydroxyazetidinone 3 has been synthesised by analogous routes, the hydroxy group being protected as an isopropyl ether during the intermediate steps. An X-ray crystal structure of compound 3 has been obtained and this reveals intramolecular hydrogen bonding between the hydroxy and carbonyl groups. The unsaturated azetidinone 2 has been prepared from 1 by stereoselective radical bromination at C-4 followed by dehydrobromination with DBU.

Enzymatic resolution of 2-substituted tetrahydroquinolines. Convenient approaches to tricyclic quinoxalinediones as potent NMDA-glycine antagonists

Two approaches leading to the enantiomerically pure tricyclic quinoxalinedione class of NMDA-glycine antagonists using enzymatic resolutions are described. An intermediate, racemic methyl 1,2,3,4- tetrahydroquinoline-2-carboxylate 3, was resolved to (S)-3