18698-96-9

Basic information

• Product Name: 2-Iodophenylacetic acid
• Synonyms: RARECHEM AL BO 1302;O-IODOPHENYLACETIC ACID;2-IODOPHENYLACETIC ACID;2-(2-IODOPHENYL)ACETIC ACID;BENZENEACETIC ACID, 2-IODO-;2-Iodo-benzeneacetic acid;2-IODOPHENYLACETIC ACID, 98+%;2-IODOPHENYLACETIC ACID, 97+%
• CAS NO: 18698-96-9
• Molecular Formula: C₈H₇IO₂
• Molecular Weight: 262.04
• EINECS: -0
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid;Miscellaneous;C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 18698-96-9.mol

Chemical Properties

• Melting Point: 116-119 °C(lit.)
• Boiling Point: 344.5 °C at 760 mmHg
• Flash Point: 162.1 °C
• Appearance: Cream/Powder
• Density: 1.885 g/cm³
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: pK1:4.038 (25°C)
• Sensitive: Light Sensitive
• BRN: 2086800
• CAS DataBase Reference: 2-Iodophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodophenylacetic acid(18698-96-9)
• EPA Substance Registry System: 2-Iodophenylacetic acid(18698-96-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• WGK Germany: 3
• HazardClass: IRRITANT, LIGHT SENSITIVE
• Hazardous Substances Data: 18698-96-9(Hazardous Substances Data)

Usage

Uses

Used in Chemical Industry:
2-Iodophenylacetic acid is used as a synthetic intermediate for the production of various chemical compounds.
Used in Pharmaceutical Industry:
2-Iodophenylacetic acid is used as a reagent to synthesize Cepharanone B, a natural and potentially antineoplastic aristolactam found in Piper longum, a medicinal plant native to India.
Used in Cosmetic Industry:
2-Iodophenylacetic acid is used in the preparation of various cosmetic products.
Used in Research and Development:
2-Iodophenylacetic acid may be used in the preparation of:
2-iodophenylacetyl chloride
3,4-dimethoxyphenyl 2-iodophenylacetate
N-2-[2-(2-iodophenyl)-acetylamino]-ethyl-2-(3,4-dichlorophenyl)-acetamide
These applications highlight the versatility of 2-Iodophenylacetic acid in different industries, from chemical synthesis to pharmaceutical research and cosmetic product development.

Preparation

synthesis of 2-Iodophenylacetic acid: The anthranilic acid solution was acidified with sulfuric acid to pH = 1 followed by a diazotization reaction. The diazonium was added dropwise to the potassium iodide-sulfuric acid solution (3.5 g KI, 1.0 mL concentrated H2SO4, 5 mL water) preheated to 60-70 °C, stirred for 30 min, placed overnight, and filtered to obtain the product. Recrystallization with 50% ethanol aqueous solution gave 3.83 g of 2-iodophenylacetic acid, the yield was 73% (calculated as o-nitrophenylacetic acid), and the melting point was 113-115 °C (117 °C reported in the literature).

InChI:InChI=1/C8H7IO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)

Upstream product

• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 40400-13-3 2-Iodobenzyl bromide 
• 143-33-9 sodium cyanide 
• 52470-94-7 (2-iodophenyl)diazomethyl ketone 
• 88-67-5 2-Iodobenzoic acid 
• 5159-41-1 2-iodobenzyl alcohol 
• 151-50-8 potassium cyanide 
• 124-38-9 carbon dioxide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 95-53-4 o-toluidine 
• 615-37-2 ortho-methylphenyl iodide 
• 59473-45-9 2-(chloromethyl)iodobenzene 
• 59-48-3 2-oxoindole 
• 103-82-2 phenylacetic acid 

Downstream Products

• 90794-29-9 ethyl 2-(2-iodophenyl)acetate 
• 2005-16-5 (2-carboxymethyl-phenyl)-dichloro-λ³-iodane 
• 54997-35-2 2-(4-Cyclopropylphenylthio)phenylessigsaeure 
• 40400-30-4 2-(4-Methylselenphenylthio)-phenylessigsaeure 
• 54920-95-5 [2-(2-amino-5-chloro-phenylsulfanyl)-phenyl]-acetic acid 
• 26059-40-5 2-(2-iodophenyl)ethan-1-ol 
• 20904-50-1 2-(4-Amino-phenylmercapto)-phenylessigsaeure 
• 13420-57-0 (2-(2-Chlorophenylthio)phenyl)acetic Acid 
• 111400-25-0 (2-(4-dimethylaminophenylthio)phenyl)acetic acid 
• 84964-61-4 <2-(3-Methylphenylthio)phenyl>acetic Acid 
• 16175-07-8 2-<2-(4-methylthiophenylthio)phenyl>acetic acid 
• 16174-91-7 <2-(3-trifluoromethylphenylthio)phenyl>acetic acid 
• 80709-55-3 <2-(3,4-dimethoxyphenylthio)phenyl>acetic acid 
• 76242-88-1 <2-(3-fluorophenylthio)phenyl>acetic acid 

Relevant articles and documents

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Wolff rearrangement of α-diazoketones using in situ generated silver nanoclusters as electron mediators

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