188637-63-0

Basic information

• Product Name: 6-BROMO-2-PYRIDINEMETHANAMINE
• Synonyms: 6-BROMO-2-PYRIDINEMETHANAMINE;6-BROMO-2-PYRIDINEMETHANEAMINE;6-Bromo-2-pyridinemethanamin;6-Bromo-2-pyridinethylamine;6-bromo-2-pyridinenethanamine;2-Pyridinemethanamine, 6-bromo-;(6-BroMopyridin-2-yl)MethanaMine;C-(6-Bromo-pyridin-2-yl)-methylamine
• CAS NO: 188637-63-0
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• EINECS: 1312995-182-4
• Product Categories: Pyridine series
• Mol File: 188637-63-0.mol

Chemical Properties

• Boiling Point: 266.853 °C at 760 mmHg
• Flash Point: 115.189 °C
• Appearance: /
• Density: 1.574 g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.42±0.39(Predicted)
• CAS DataBase Reference: 6-BROMO-2-PYRIDINEMETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-PYRIDINEMETHANAMINE(188637-63-0)
• EPA Substance Registry System: 6-BROMO-2-PYRIDINEMETHANAMINE(188637-63-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 188637-63-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research and Development:
6-Bromo-2-pyridinemethanamine is used as a research compound for the development of new chemical entities. Its unique structure allows for the exploration of its properties and potential applications in various chemical reactions and processes.
Used in Organic Synthesis:
6-Bromo-2-pyridinemethanamine is used as a synthetic intermediate for the preparation of more complex molecules. Its reactivity and the presence of the bromine atom make it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Drug Discovery:
6-Bromo-2-pyridinemethanamine is used as a lead compound in drug discovery, where its structure can be further modified to develop potential therapeutic agents. Its interaction with biological targets can be explored for the treatment of various diseases and conditions.
Used in Material Science:
6-Bromo-2-pyridinemethanamine is used as a component in the development of new materials with specific properties, such as electronic, optical, or catalytic functions. Its incorporation into materials can lead to novel applications in various industries.

InChI:InChI=1/C6H7BrN2/c7-6-3-1-2-5(4-8)9-6/h1-3H,4,8H2

Upstream product

• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 
• 33674-96-3 2-bromo-6-(hydroxymethyl)pyridine 
• 83004-10-8 2-bromo-6-bromomethylpyridine 
• 727356-19-6 2-bromo-6-(chloromethyl)pyridine 
• 521917-57-7 2-[(6-bromopyridin-2-yl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione 

Downstream Products

• 404034-88-4 N-(6-bromopyridin-2-ylmethyl)-2-nitrobenzenesulfonamide 
• 1001413-86-0 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (6-bromo-pyridin-2-ylmethyl)-amide trifluoroacetic acid salt 
• 404034-89-5 {2-[6-(5-cyanopentyl)pyridin-2-yl]methyl}-2-nitrobenzenesulfonamide 
• 404034-91-9 3-(2-nitrobenzenesulfonyl)-3,6,17-triazabicyclo[11,3,1]heptadeca-1⁽¹⁷⁾,13,15-trien-5-one 
• 404034-90-8 2-bromo-N-(5-{6-[2-(2-nitrobenzenesulfonylamino)methyl]pyridin-2-yl}hexyl) acetamide 
• 1431656-36-8 N-((6-bromopyridin-2-yl)-methyl)benzamide 
• 1431656-25-5 5-Bromo-3-phenylimidazo[1,5-a]pyridine 
• 1431656-27-7 3-phenyl-5-(phenylethynyl)imidazo[1,5-a]pyridine 

Relevant articles and documents

General C-H Arylation Strategy for the Synthesis of Tunable Visible Light-Emitting Benzo[a]imidazo[2,1,5-c,d]indolizine Fluorophores

Herein we report the discovery of the benzo[a]imidazo[2,1,5-c,d]indolizine motif displaying tunable emission covering most of the visible spectrum. The polycyclic core is obtained from readily available amides via a chemoselective process involving Tf2O-mediated amide cyclodehydration, followed by intramolecular C-H arylation. Additionally, these fluorescent heterocycles are easily functionalized using electrophilic reagents, enabling divergent access to varied substitution. The effects of said substitution on the compounds' photophysical properties were rationalized by density functional theory calculations. For some compounds, emission wavelengths are directly correlated to the substituent's Hammett constants. Easily introduced nonconjugated reactive functional groups allow the labeling of biomolecules without modification of emissive properties. This work provides a straightforward platform for the synthesis of new moderately bright fluorescent dyes remarkable for their chemical stability, predictability, and unusually high excitation-emission differential.

Triflic anhydride mediated synthesis of imidazo[1,5-a]azines

Imidazo[1,5-a]azines are synthesized in moderate to excellent yields using a mild cyclodehydration/aromatization reaction triggered by the use of triflic anhydride (Tf2O) and 2-methoxypyridine (2-MeOPyr). Various substitution patterns and functional groups were found to be compatible under the optimized conditions. In addition, a 5-bromo-3-aryl derivative was also shown to be active in a Sonogashira cross-coupling and direct arylation reactions. A tertiary amide was compatible as a substrate leading to the synthesis of an imidazo[1,5-a]pyridinium triflate.

Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

The synthesis, structure-activity relationships (SAR), and biological results of pyridyl-substituted azaindole based tricyclic inhibitors of IKK2 are described. Compound 4m demonstrated potent in vitro potency, acceptable pharmacokinetic and physicochemical properties, and efficacy when dosed orally in a mouse model of inflammatory bowel disease.

ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS

The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.

A convenient one-pot preparation and applications of high loading benzhydrylamine solid phase linkers

A rapid and convenient one-pot route to solid supported benzhydrylamine linkers with high chemical loading is described. Such linkers possess differing levels of acid lability, which could be exploited in solid phase synthesis applications. They have also been utilised to prepare novel and potentially useful N-methylated derivatives. We also report an effective on-resin purification strategy for reductive amination, which is facilitated by the varying acid lability of resin-linked secondary amines or tertiary amine by-products.

1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY

The present invention provides for tricyclic compounds having the formula (I) wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS

The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.