188879-03-0

Basic information

• Product Name: 3-(2-METHOXYBENZYLOXY)PROPAN-1-OL
• Synonyms: 3-(2-METHOXYBENZYLOXY)PROPAN-1-OL
• CAS NO: 188879-03-0
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24
• Mol File: 188879-03-0.mol

Chemical Properties

• Boiling Point: 322.1°Cat760mmHg
• Flash Point: 148.6°C
• Appearance: /
• Density: 1.071g/cm³
• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 3-(2-METHOXYBENZYLOXY)PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHOXYBENZYLOXY)PROPAN-1-OL(188879-03-0)
• EPA Substance Registry System: 3-(2-METHOXYBENZYLOXY)PROPAN-1-OL(188879-03-0)

Safety Data

• Hazardous Substances Data: 188879-03-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H16O3/c1-13-11-6-3-2-5-10(11)9-14-8-4-7-12/h2-3,5-6,12H,4,7-9H2,1H3

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 612-16-8 (2-methoxyphenyl)methanol 
• 627-18-9 1-bromo-3-propanol 
• 52289-93-7 o-Methoxybenzyl bromide 
• 504-63-2 trimethyleneglycol 
• 7035-02-1 o-Methoxybenzyl chloride 

Downstream Products

• 773092-61-8 toluene-4-sulfonic acid 3-(2-methoxybenzyloxy)propyl ester 
• 773092-62-9 1-(3-iodopropoxymethyl)-2-methoxybenzene 
• 773092-65-2 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 773092-64-1 (3RS,4RS)-3-hydroxy-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-piperidin-1-carboxylic acid tert-butylester 

Relevant articles and documents

Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.

RENIN INHIBITORS

The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

The discovery and preparation of disubstituted novel amino-aryl-piperidine- based renin inhibitors

Recently, trans-disubstituted oxo-aryl-piperidines have been identified as small molecule nonpeptide renin inhibitors for the modulation of hypertension. Herein, we report on the discovery and preparation of a new class of novel cis-disubstituted amino-aryl-piperidines as a mixture of enantiomers that are potent in vitro renin inhibitors and also, possess in vivo antihypertensive activity in a double transgenic mouse model.

Piperidine-renin inhibitors compounds with improved physicochemical properties

Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D((pH 7.4)) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.