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2-(4-Nitrophenyl)-2H-1,2,3-triazole is a chemical compound with the molecular formula C9H6N4O2. It is a triazole derivative featuring a nitrophenyl group attached to the triazole ring. 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE is characterized by its yellow color, which is attributed to the nitro group present in its structure. Due to its potential toxicity, it is crucial to handle this compound with care.

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  • 18922-72-0 Structure
  • Basic information

    1. Product Name: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE
    2. Synonyms: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE
    3. CAS NO:18922-72-0
    4. Molecular Formula: C8H6N4O2
    5. Molecular Weight: 190.1588
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 18922-72-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 380.7°Cat760mmHg
    3. Flash Point: 184°C
    4. Appearance: /
    5. Density: 1.46g/cm3
    6. Vapor Pressure: 5.35E-06mmHg at 25°C
    7. Refractive Index: 1.696
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE(18922-72-0)
    12. EPA Substance Registry System: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE(18922-72-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 18922-72-0(Hazardous Substances Data)

18922-72-0 Usage

Uses

Used in Organic Synthesis:
2-(4-Nitrophenyl)-2H-1,2,3-triazole serves as a valuable building block in organic synthesis, contributing to the creation of a wide range of chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(4-Nitrophenyl)-2H-1,2,3-triazole is utilized as a key component in the development of various drugs. Its unique structure allows it to be incorporated into molecules with specific therapeutic properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 2-(4-Nitrophenyl)-2H-1,2,3-triazole is employed as a building block for the synthesis of compounds with pesticidal or herbicidal activities, contributing to the development of effective crop protection agents.
Used in Biological Research:
2-(4-Nitrophenyl)-2H-1,2,3-triazole has been studied for its potential biological activities, such as antimicrobial, antitumor, and anti-inflammatory properties. This makes it a candidate for further research and development in the field of medicine and healthcare.

Check Digit Verification of cas no

The CAS Registry Mumber 18922-72-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,2 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 18922-72:
(7*1)+(6*8)+(5*9)+(4*2)+(3*2)+(2*7)+(1*2)=130
130 % 10 = 0
So 18922-72-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N4O2/c13-12(14)8-3-1-7(2-4-8)11-9-5-6-10-11/h1-6H

18922-72-0Relevant articles and documents

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

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Paragraph 000186; 000501, (2016/05/02)

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

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Paragraph 2111; 2112, (2016/08/03)

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

NOVEL COMPOUNDS

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Page/Page column 65, (2016/04/20)

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Palladium-Catalyzed 2H-1,2,3-Triazole-Directed Oxidative Alkoxylation of Arenes with Alcohols

Shi, Wenjuan,Shi, Zhangjie

supporting information, p. 974 - 980 (2016/02/18)

A palladium catalyzed ortho-alkoxylation of aryl C-H bond was accomplished with primary and secondary alcohols as alkoxylation reagents and with triazole as new directing group. This transformation has a good functional group tolerance and is not sensitive to moisture and air. A palladium catalyzed ortho-alkoxylation of aryl C-H bond with alcohols was described. Trizaole was used as new directing group. A series of functional groups could be tolerated and the reaction is not sensitive to moisture and air.

HIV PROTEASE INHIBITORS

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Page/Page column 33-34, (2013/05/21)

Compounds of Formula I are disclosed: wherein A, R1, R2, R3, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which

Amide thiadiazole inhibitors of plasminogen activator inhibitor-1

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Page/Page column 24, (2010/02/12)

Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a ph

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs

Jia, Zhaozhong J.,Wu, Yanhong,Huang, Wenrong,Zhang, Penglie,Clizbe, Lane A.,Goldman, Erick A.,Sinha, Uma,Arfsten, Ann E.,Edwards, Susan T.,Alphonso, Merlyn,Hutchaleelaha, Athiwat,Scarborough, Robert M.,Zhu, Bing-Yan

, p. 1221 - 1227 (2007/10/03)

A variety of P4 motifs have been examined to increase the binding affinity and in vitro anticoagulant potency of our biphenyl 1-(2-naphthyl)-1H-pyrazole-5- carboxylamide-based fXa inhibitors. Highly potent 2-naphthyl-P1 fXa inhibitors (Ki≤2 nM) with improved in vitro anticoagulant activity (2×TG≤1 μM) and respectable pharmacokinetic properties have been discovered.

Azole antifungal agents, processes for the preparation thereof, and intermediates

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Page 74-75, (2010/01/31)

A compound represented by the general formula: wherein R1 and R2 denote a halogen atom or hydrogen atoms; R3 means a hydrogen atoms or lower alkyl group; r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic rings, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

Azole compounds, their production and use

-

, (2008/06/13)

PCT No. PCT/JP96/00325 Sec. 371 Date Oct. 17, 1996 Sec. 102(e) Date Oct. 17, 1996 PCT Filed Feb. 15, 1996 PCT Pub. No. WO96/25410 PCT Pub. Date Aug. 20, 1996The present invention provides an azole compound represented by the formula (I): wherein Ar is an

Optically active antifungal azoles. X. Synthesis and antifungal activity of N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones

Kitazaki, Tomoyuki,Ichikawa, Takashi,Tasaka, Akihiro,Hosono, Hiroshi,Matsushita, Yoshihiro,Hayashi, Ryogo,Okonogi, Kenji,Itoh, Katsumi

, p. 1935 - 1946 (2007/10/03)

New optically active antifungal azoles, N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]azolones (1, 2, 3), were prepared in a stereocontrolled manner. Compounds 1

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