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1-Trityl-1H-imidazole-4-carboxylic acid is an organic compound characterized by its trityl group and imidazole ring, which contributes to its unique chemical properties. It is a key intermediate in the synthesis of various biologically active molecules and has potential applications in the pharmaceutical industry due to its ability to form complex structures with other molecules.

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  • 191103-80-7 Structure
  • Basic information

    1. Product Name: 1-Trityl-1H-imidazole-4-carboxylic acid
    2. Synonyms: 1-Trityl-1H-imidazole-4-carboxylic acid;1-Tritylimidazole-3-carboxylic aicd;1-Trityl-1H-imidazole-4-carboxylic acid 1-Tritylimidazole-3-carboxylic aicd
    3. CAS NO:191103-80-7
    4. Molecular Formula: C23H18N2O2
    5. Molecular Weight: 354.41
    6. EINECS: N/A
    7. Product Categories: blocks;Carboxes;Imidazoles
    8. Mol File: 191103-80-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 546.287 °C at 760 mmHg
    3. Flash Point: 284.184 °C
    4. Appearance: /
    5. Density: 1.165 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-Trityl-1H-imidazole-4-carboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Trityl-1H-imidazole-4-carboxylic acid(191103-80-7)
    11. EPA Substance Registry System: 1-Trityl-1H-imidazole-4-carboxylic acid(191103-80-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 191103-80-7(Hazardous Substances Data)

191103-80-7 Usage

Uses

Used in Pharmaceutical Industry:
1-Trityl-1H-imidazole-4-carboxylic acid is used as a reactant for the synthesis of spiro[indole-3,2''-pyrrolidin]-2(1H)-one based inhibitors. These inhibitors have potential applications in the development of new drugs targeting specific biological pathways, making them valuable in the treatment of various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 191103-80-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,1,0 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 191103-80:
(8*1)+(7*9)+(6*1)+(5*1)+(4*0)+(3*3)+(2*8)+(1*0)=107
107 % 10 = 7
So 191103-80-7 is a valid CAS Registry Number.

191103-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Trityl-1H-imidazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1-tritylimidazole-4-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:191103-80-7 SDS

191103-80-7Relevant articles and documents

Intermediate for preparing medetomidine and its preparation method and use

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Paragraph 0094-0096, (2018/08/03)

The invention provides an intermediate for preparing medetomidine. The intermediate is a compound shown in the formula (I). The invention also provides a preparation method of the intermediate, and ause of the intermediate in the preparation of medetomidine. The compound shown in the formula (I) is used for preparation of medetomidine so that the raw material is cheap and easy to obtain, synthesis processes are simple, the reaction cycle is short, the environmental pollution is avoided, operation is simple, the harsh reaction conditions are avoided, the operation and post-treatment are simple, the yield and the product purity are high, the intermediate in each step is a solid and is easy to purify, a production cost is low, and the intermediate is suitable for industrial large-scale production and conforms to the principle of green chemistry.

PREPARATION METHOD OF DEXMEDETOMIDINE INTERMEDIATE

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Paragraph 0024, (2016/10/11)

The present invention discloses a preparation method of 2,3-dimethyl phenyl-1-trityl-imidazole-4-ketone. In accordance with this method, imidazole-4-ethyl formate is used as a raw material; ethyl formate is used for amino protection, 1-trityl-1H-imidazole

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

Chong, Pek,Sebahar, Paul,Youngman, Michael,Garrido, Dulce,Zhang, Huichang,Stewart, Eugene L.,Nolte, Robert T.,Wang, Liping,Ferris, Robert G.,Edelstein, Mark,Weaver, Kurt,Mathis, Amanda,Peat, Andrew

supporting information, p. 10601 - 10609 (2013/02/23)

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the key hydrogen-bonding motif. This led directly to the design of compound 43 that exhibits remarkable antiviral activity (EC50 1 nM) against a wide range of NNRTI-resistant viruses and a favorable pharmacokinetic profile across multiple species.

IMIDAZOLE CARBOXAMIDES

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Page/Page column 17, (2010/02/17)

The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.

THIA-TRIAZA-CYCLOPENTAZULENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER

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Page/Page column 29-30, (2010/11/05)

The present invention encompasses compounds of general formula (1) wherein 5 R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and th

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

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Page/Page column 21, (2009/02/11)

Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

CHEMICAL COMPOUNDS

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Page/Page column 105, (2009/01/24)

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Amide substituted xanthine derivatives

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, (2008/06/13)

The present invention is a 1,3,8 substituted xanthine derivative of formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

Novel farnesyl protein transferase inhibitors as antitumor agents

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Page 470, (2010/02/07)

Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY

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, (2012/04/23)

The present invention is a 1,3,8 substituted xanthine derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (I) and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

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