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(R)-1-Chloro-2-propanol is an organic compound that consists of carbon, hydrogen, chlorine, and oxygen atoms. It is a type of chlorohydrin and an isomer of 2-chloropropanol. The "(R)" prefix indicates the specific configuration of the chiral center in the molecule, which is crucial for its properties and applications. (R)-1-Chloro-2-propanol is utilized in the chemical industry for the production of various products, but it is important to note that it is toxic and corrosive, necessitating careful handling and adherence to safety protocols.

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  • 19141-39-0 Structure
  • Basic information

    1. Product Name: (R)-1-Chloro-2-propanol
    2. Synonyms: 2-PROPANOL, 1-CHLORO-, (2R)-;(R)-1-CHLORO-2-PROPANOL;(R)-1-CHLORO-2-PROPANOL 98+%;(2R)-1-Chloro-2-propanol;(R)-1-Chloro-2-propa;(R)-1-Chloropropan-2-ol;(2R)-1-chloropropan-2-ol
    3. CAS NO:19141-39-0
    4. Molecular Formula: C3H7ClO
    5. Molecular Weight: 94.54
    6. EINECS: N/A
    7. Product Categories: API intermediates;Chiral Compound
    8. Mol File: 19141-39-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 126.499 °C at 760 mmHg
    3. Flash Point: 54.541 °C
    4. Appearance: /
    5. Density: 1.083 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 14.09±0.20(Predicted)
    10. CAS DataBase Reference: (R)-1-Chloro-2-propanol(CAS DataBase Reference)
    11. NIST Chemistry Reference: (R)-1-Chloro-2-propanol(19141-39-0)
    12. EPA Substance Registry System: (R)-1-Chloro-2-propanol(19141-39-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. RIDADR: 2611
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup:
    9. Hazardous Substances Data: 19141-39-0(Hazardous Substances Data)

19141-39-0 Usage

Uses

Used in Chemical Industry:
(R)-1-Chloro-2-propanol is used as a chemical intermediate for the synthesis of various products. Its unique structure allows it to be a key component in the manufacturing process of certain chemicals, contributing to the final product's properties and performance.
Used in Pharmaceutical Industry:
(R)-1-Chloro-2-propanol is used as a starting material for the production of certain pharmaceutical compounds. Its reactivity and structural features make it a valuable precursor in the synthesis of drugs, potentially leading to the development of new medications.
Used in Agrochemical Industry:
(R)-1-Chloro-2-propanol is used as a building block for the creation of agrochemicals, such as pesticides and herbicides. Its chemical properties enable it to be incorporated into the molecular structure of these products, enhancing their effectiveness in agricultural applications.
Used in Material Science:
(R)-1-Chloro-2-propanol is used as a component in the development of new materials, such as polymers and resins. Its presence in these materials can influence their physical and chemical properties, making them suitable for specific applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 19141-39-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,1,4 and 1 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 19141-39:
(7*1)+(6*9)+(5*1)+(4*4)+(3*1)+(2*3)+(1*9)=100
100 % 10 = 0
So 19141-39-0 is a valid CAS Registry Number.

19141-39-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-1-chloropropan-2-ol

1.2 Other means of identification

Product number -
Other names 1-chloro-propane-2-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19141-39-0 SDS

19141-39-0Relevant articles and documents

Empirical method for predicting enantioselectivity in catalytic reactions: demonstration with lipase and oxazaborolidine

Ema, Tadashi,Ura, Norichika,Yoshii, Masataka,Korenaga, Toshinobu,Sakai, Takashi

supporting information; experimental part, p. 9583 - 9591 (2010/01/06)

We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition-state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products could be predicted correctly in most cases (28 out of 30).

Generation of a solid Bronsted acid site in a chiral framework

Ingleson, Michael J.,Barrio, Jorge Perez,Bacsa, John,Dickinson, Calum,Park, Hyunsoo,Rosseinsky, Matthew J.

, p. 1287 - 1289 (2008/12/21)

Protonation of chiral porous materials introduces a Bronsted acid centre, the structure of which is unique to the heterogeneous phase requiring pore wall confinement for stable isolation. The Royal Society of Chemistry.

A new dinuclear chiral salen complexes for asymmetric ring opening and closing reactions: Synthesis of valuable chiral intermediates

Thakur, Santosh Singh,Chen, Shu-Wei,Li, Wenji,Shin, Chang-Kyo,Kim, Seong-Jin,Koo, Yoon-Mo,Kim, Geon-Joong

, p. 1862 - 1872 (2007/10/03)

A new dinuclear chiral Co(salen) complexes bearing group 13 metals have been synthesized and characterized. The easily prepared complexes exhibited very high catalytic reactivity and enantioselectivity for the asymmetric ring opening of epoxides with H2O, chloride ions and carboxylic acids and consequently provide enantiomerically enriched terminal epoxides (>99% ee). It also catalyzes the asymmetric cyclization of ring opened product, to prepare optically pure terminal epoxides in one step. The homogeneous dinuclear chiral Co(salen) have been covalently immobilized on MCM-41. The potential benefits of heterogenization include facilitation of catalyst separation and recyclability requiring very simple techniques. The system described is very efficient.

Highly reactive and enantioselective kinetic resolution of terminal epoxides with H2O and HCl catalyzed by new chiral (salen)Co complex linked with Al

Thakur, Santosh Singh,Li, Wenji,Kim, Seong-Jin,Kim, Geon-Joong

, p. 2263 - 2266 (2007/10/03)

The asymmetric hydrolytic kinetic resolution (HKR) of racemic terminal epoxides by new easily synthesized dimeric chiral (salen)Co bearing Al, provides a practical and straightforward method for the synthesis of enantiomerically enriched terminal epoxides (>99% ee) and diols. An inorganic acid, HCl is applied first time for the asymmetric ring opening reaction of terminal epoxides. Reactions are conveniently carried out at room temperature under an air atmosphere.

The effect of catechin derivatives on the enantioselectivity of lipase-catalyzed hydrolyses of alkynol benzoate esters

Nakamura, Kaoru,Takenaka, Keishi

, p. 415 - 422 (2007/10/03)

Polyphenols, such as (+)-catechin and pyrogallol could be used to enhance stereochemical control in the lipase-catalyzed hydrolysis of alkynol benzoate esters, leading to increased enantioselectivities in the kinetic resolution of alkynols with lipase Amano AH.

Oxidation of olefins by palladium(II): Part 17. An asymmetric chlorohydrin synthesis catalyzed by a bimetallic palladium(II) complex

El-Qisairi, Arab,Henry, Patrick M.

, p. 50 - 60 (2007/10/03)

Previous studies showed that oxidation of α-olefins with monometallic catalysts containing chiral diphosphines and diamines gave chlorohydrins with poor to good enantioselectivites (28-82% ee). The present studies demonstrate that bimetallic catalysts containing a β-triketone and bridging chiral diphosphine and diamines are excellent catalysts for this reaction giving enantioselectivites considerably higher than the monometallic catalysts. Enantioselectivities were more than 50% for most olefins tested. The highest optical purities were 94% ee for propene and 93% ee for allylphenyl ether. A useful feature of this asymmetric synthesis is the fact it is a net air oxidation.

Enantiomerically enriched bifunctional sec-alcohols prepared by Candida antarctica lipase B catalysis. Evidence of non-steric interactions

Rotticci, Didier,Orrenius, Christian,Hult, Karl,Norin, Torbjoem

, p. 359 - 362 (2007/10/03)

Transesterification catalysed by Candida antarctica lipase B was used for the preparation of enantiomerically enriched bifunctional sec-alcohols. The enantiomeric ratio, E, for 3-butyn-2-ol was increased from 1.3 to over 500 by adding an easily removable protecting group. Kinetic resolution of bromohydrins and chlorohydrins bearing a halogen on the large substituent showed high enantioselectivity (E >80). On the other hand, halohydrins with the halogen on the medium group showed low E. Large differences in enantioselectivity were found by substituting the halogen atom of 1-halo-2-alkanols by a methyl group. These differences corresponded to more than 2 kcal mol-1 and were ascribed to non-steric interactions.

ASSYMETRIC REDUCTION OF KETONES BY GLYCEROL DEHYDROGENASE FROM GEOTRICUM

Nakamura, Kaoru,Yoneda, Tetsuo,Miyai, Takehiko,Ushio, Kazutoshi,Oka, Shinzaburo,Ohno, Atsuyoshi

, p. 2453 - 2454 (2007/10/02)

Glycerol dehydrogenase from Geotricum was used as a catalyst for asymmetric reduction of ketones.A 2-propanol-NAD couple was employed to supply NADH.

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