Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

DOI: 10.1016/S0960-894X(98)00069-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 545 - 548 (1998)

Update date:2022-08-10

Topics:

Authors:

Beall, Howard D.

Hudnott, Anna R.

Winski, Shannon

Siegel, David

Swann, Elizabeth

Ross, David

Moody, Christopher J.

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Article abstract of DOI:10.1016/S0960-894X(98)00069-9

A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.

Full text of DOI:10.1016/S0960-894X(98)00069-9

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