194805-14-6

Basic information

• Product Name: (1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole
• Synonyms: (R)-5-bromo-1-methyl-2-tritylisoindoline;(1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole
• CAS NO: 194805-14-6
• Molecular Formula: C₂₈H₂₄BrN
• Molecular Weight: 454.40086
• Mol File: 194805-14-6.mol

Chemical Properties

• Boiling Point: 507.6°C at 760 mmHg
• Flash Point: 260.8°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 2E-10mmHg at 25°C
• Refractive Index: 1.645
• PKA: 4.73±0.40(Predicted)
• CAS DataBase Reference: (1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole(194805-14-6)
• EPA Substance Registry System: (1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole(194805-14-6)

Safety Data

• Hazardous Substances Data: 194805-14-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
(1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole is used as a synthetic intermediate for the development of novel chemical reactions. Its unique structure, including the trityl group, allows for the exploration of new synthetic pathways and the creation of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole is used as a precursor in the synthesis of biologically active molecules. Its potential to be modified and functionalized makes it a valuable candidate for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
(1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole is utilized as a building block in medicinal chemistry for the design and synthesis of new pharmaceutical compounds. Its structural features, such as the bromine atom and the trityl group, can be leveraged to enhance the pharmacological properties of the resulting molecules.
Used in Chemical Synthesis Education:
(1R)-5-Bromo-1-methyl-2-trityl-2,3-dihydro-1H-isoindole can also be used as a teaching tool in chemical synthesis education, providing students with hands-on experience in working with complex organic molecules and understanding the principles of organic synthesis and reaction mechanisms.

InChI:InChI=1/C28H24BrN/c1-21-27-18-17-26(29)19-22(27)20-30(21)28(23-11-5-2-6-12-23,24-13-7-3-8-14-24)25-15-9-4-10-16-25/h2-19,21H,20H2,1H3/t21-/m1/s1

Upstream product

• 335428-62-1 (1R)-5-bromo-1-methyl-2,3-dihydro-1H-isoindole 
• 76-83-5 trityl chloride 
• 24358-62-1 (R)-1-(4-bromophenyl)ethylamine 
• 223595-15-1 (R)-5-bromo-2-(2,2-dimethylpropanoyl)-1-methyl-isoindoline 
• 223595-23-1 5-bromo-2-{(1R)-1-[(2,2-dimethylpropanoyl)amino]ethyl}benzyl chloride 
• 107-21-1 ethylene glycol 
• 124-63-0 methanesulfonyl chloride 
• 223595-22-0 5-bromo-2-{(1R)-1-[(2,2-dimethylpropanoyl)amino]ethyl}benzyl acetate 

Downstream Products

• 194804-75-6 garenoxacin 
• 223595-20-8 2-[(1R)-1-methyl-2-trityl-2,3-dihydro-1H-5-isoindolyl]-1,3,6,2-dioxazaborocane 

Relevant articles and documents

Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

The first example of cobalt-catalyzed C(sp2)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).

Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient

This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: wherein R1represents a hydrogen atom or a carboxyl-protecting group; R2represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amino groups, alkylidene groups, oxo group and groups each forming a cycloalkane group together with the carbon atom to which R4bonds; R5represents a hydrogen atom, an amino-protecting group, a substituted or unsubstituted alkyl, cycloalkyl, alkylsulfonyl, arylsulfonyl, acyl or aryl group; R6represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group, a protected or unprotected hydroxyl or amino group or a nitro group; and A represents CH or C—R7in which R7represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy or alkylthio group or a protected or unprotected hydroxyl group, and to a salt of a 7-isoindoline-quinolonecarboxylic acid represented by the general formula [1], a hydrate thereof and a composition comprising them as an active ingredient.