197240-27-0Relevant articles and documents
Spiro[indene-1,4′-oxa-zolidinones] Synthesis via Rh(III)-Catalyzed Coupling of 4-Phenyl-1,3-oxazol-2(3 H)-ones with Alkynes: A Redox-Neutral Approach
Liu, Zhongsu,Zhang, Wenjing,Guo, Shan,Zhu, Jin
, p. 11945 - 11957 (2019/10/02)
Transition-metal-catalyzed C-H activation synthesis of heterocyclic spiro[4,4]nonanes has persistently witnessed the use of additional stoichiometric transition-metal oxidant when employing C=C bond as the spiro ring closure site. Herein, we have addressed the issue by reporting a redox-neutral strategy for spiro[indene-1,4′-oxa-zolidinones] synthesis via Rh(III)-catalyzed coupling of 4-phenyl-1,3-oxazol-2(3H)-ones with alkynes. The synthesis features a broad substrate scope and high regiospecificity.
OPTICAL IMAGING CONTRAST AGENTS FOR IMAGING LUNG CANCER
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Page/Page column 20, (2008/06/13)
The invention provides contrast agents for optical imaging of lung cancer in patients. The contrast agents may be used in diagnosis of lung cancer, for follow up of progress in disease development, for follow up of treatment of lung cancer and for surgica
OPTICAL IMAGING CONTRAST AGENTS FOR IMAGING LUNG CANCER
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Page/Page column 24, (2008/06/13)
The invention provides contrast agents for optical imaging of prostate cancer in patients. The contrast agents may be used in diagnosis of prostate cancer, for follow up of progress in disease development, for follow up of treatment of prostate cancer and
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors
Puig, Carles,Miralpeix, Montserrat,Puig, Jaume,Beleta, Jordi,Huerta, Josep M.,López, Manel,Segarra, Victor,Ryder, Hamish,Palacios, José M.,Crespo, María I.,Godessart, Núria,Feixas, Joan,Ibarzo, Javier,Jiménez, Juan-Miguel,Soca, Lídia,Cardelús, Ignasi,Heredia, Ascensión
, p. 214 - 223 (2007/10/03)
A series of 3,4-diaryloxazolones were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). Extensive structure-activity relationship work was carried out within this series, and a number of potent and selective COX-2 inhibitors we