198633-76-0

Basic information

• Product Name: 2-FLUORO-6-METHYLBENZONITRILE
• Synonyms: 2-Cyano-3-fluorotoluene;2-Cyano-3-fluorotoluene, 6-Fluoro-o-tolunitrile
• CAS NO: 198633-76-0
• Molecular Formula: C₈H₆FN
• Molecular Weight: 135.14
• Product Categories: Benzene nitrile;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
• Mol File: 198633-76-0.mol

Chemical Properties

• Melting Point: 39-46 °C
• Boiling Point: 207.4 °C at 760 mmHg
• Flash Point: 91 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.226mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-FLUORO-6-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-METHYLBENZONITRILE(198633-76-0)
• EPA Substance Registry System: 2-FLUORO-6-METHYLBENZONITRILE(198633-76-0)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• RIDADR: UN 3439 6.1/PG III
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 198633-76-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-6-methylbenzonitrile is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Fluoro-6-methylbenzonitrile is employed as an intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Organic Compounds Synthesis:
2-Fluoro-6-methylbenzonitrile is used as a building block in the synthesis of various organic compounds, enabling the creation of a wide range of chemical products with diverse applications.
Used as a Reagent in Organic Chemical Reactions:
As a reagent, 2-Fluoro-6-methylbenzonitrile plays a crucial role in facilitating specific organic chemical reactions, contributing to the advancement of organic chemistry and the development of new chemical processes.

InChI:InChI=1/C8H6FN/c1-6-3-2-4-8(9)7(6)5-10/h2-4H,1H3

Upstream product

• 6575-09-3 2-chloro-6-methyl-benzonitrile 
• 446-52-6 2-Fluorobenzaldehyde 
• 74-88-4 methyl iodide 
• 557-21-1 zinc(II) cyanide 
• 883502-14-5 1-fluoro-2-iodo-3-methylbenzene 
• 748101-41-9 zinc cyanide 

Downstream Products

• 1255207-47-6 3-bromo-6-fluoro-2-methyl-benzonitrile 
• 1207529-96-1 4-methyl-1H-indazol-3-amine 
• 869371-52-8 N-(2-(aminomethyl)-3-methylphenyl)-N-methylmethanesulfonamide 
• 1073159-81-5 N-(2-cyano-3-methyl-phenyl)-N-methyl-methanesulfonamide 
• 1255207-48-7 3-ethenyl-6-fluoro-2-methylbenzonitrile 
• 1255207-46-5 6-fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile 
• 1426071-25-1 tert-butyl (3S)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate 
• 1426072-82-3 tert-butyl (3R,9aS)-3-(3-cyano-4-fluoro-2-methylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 
• 1426071-26-2 tert-butyl (3S,9aS)-3-(3-cyano-4-fluoro-2-methylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 
• 1426073-08-6 3-(2-bromo-acetyl)-6-fluoro-2-methyl-benzonitrile 
• 1426073-09-7 (3R,9aS)-3-(3-cyano-4-fluoro-2-methyl-phenyl)-3-hydroxy-hexahydro-pyrazino[2,1-c][ 1,4]oxazine-8-carboxylic acid tert-butyl ester 
• 1426073-10-0 (S)-3-(3-cyano-4-fluoro-2-methyl-phenyl)-6,7,9,9a-tetrahydro-1H-pyrazino[2,1-c][1,4]oxazine-8-carboxylic acid tert-butyl ester 
• 1426071-27-3 tert-butyl (3R)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxylethyl]-3-(hydroxymethyl)piperazine-1-carboxylate 
• 1426072-83-4 tert-butyl (3S,9aR)-3-(3-cyano-4-fluoro-2-methylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula(I) or a pharmaceutically acceptable salt thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.

Aminoisoquinolines and aminotheinopyridine derivatives and their use as anti-inflammatory agents

PCT No. PCT/SE97/00589 Sec. 371 Date Aug. 19, 1997 Sec. 102(e) Date Aug. 19, 1997 PCT Filed Apr. 9, 1997 PCT Pub. No. WO97/38977 PCT Pub. Date Oct. 23, 1997Compounds of formula I wherein R, R1, R2, and R3 and A are as defined herein, together with pharmaceutically acceptable salts, enantiomers or tautomers are useful as pharmaceuticals, particularly in the treatment of inflammatory disease.