200049-46-3

Basic information

• Product Name: 7-Bromo-2,3-dihydro-isoindol-1-one
• Synonyms: 7-Bromo-2,3-dihydro-isoindol-1-one;1H-Isoindol-1-one, 7-broMo-2,3-dihydro-;7-broMo-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 200049-46-3
• Molecular Formula: C₈H₆BrNO
• Molecular Weight: 212.0433
• Product Categories: Pharmaceutical intermediate
• Mol File: 200049-46-3.mol

Chemical Properties

• Boiling Point: 452.172 °C at 760 mmHg
• Flash Point: 227.266 °C
• Appearance: /
• Density: 1.666 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.36±0.20(Predicted)
• CAS DataBase Reference: 7-Bromo-2,3-dihydro-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-2,3-dihydro-isoindol-1-one(200049-46-3)
• EPA Substance Registry System: 7-Bromo-2,3-dihydro-isoindol-1-one(200049-46-3)

Safety Data

• Hazardous Substances Data: 200049-46-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Bromo-2,3-dihydro-isoindol-1-one serves as a crucial precursor in the synthesis of various biologically active compounds. Its unique structure allows for the development of new pharmaceuticals with potential therapeutic applications.
Used in Neuroscience Research:
In the field of neuroscience, 7-Bromo-2,3-dihydro-isoindol-1-one is studied for its potential therapeutic properties, particularly in addressing central nervous system disorders. Its chemical structure may contribute to the discovery of novel treatments for neurological conditions.
Used in Chemical Research and Development:
Due to its distinctive structural features, 7-Bromo-2,3-dihydro-isoindol-1-one may find applications in other areas of chemical research and development. Its versatility as a building block can lead to the creation of new compounds with diverse applications in various industries.

InChI:InChI=1/C8H6BrNO/c9-6-3-1-2-5-4-10-8(11)7(5)6/h1-3H,4H2,(H,10,11)

Upstream product

• 777859-74-2 methyl?2-bromo-6-(bromomethyl)benzoate 
• 99548-56-8 methyl 2-bromo-6-methyl-benzoate 
• 90259-31-7 2-bromo-6-methylbenzoic acid 
• 535961-79-6 2-bromo-6-methylbenzoyl chloride 
• 75366-10-8 1-bromo-2-(bromomethyl)-3-methylbenzene 

Downstream Products

• 200049-49-6 7-(4-Fluoro-phenyl)-2,3-dihydro-isoindol-1-one 
• 935269-07-1 2-(3-oxo-2,3-dihydro-1H-isoindol-4-yl)-pyrrole-1-carboxylic acid tert-butyl ester 
• 935269-16-2 5-benzyloxy-2-(3-oxo-2,3-dihydro-1H-isoindol-4-yl)-indole-1-carboxylic acid tert-butyl ester 
• 877150-62-4 2-benzyl-7-bromoisoindolin-1-one 

Relevant articles and documents

SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS

The present invention is directed to novel substituted dihydro-isoindolone compounds of formula (I): and forms thereof, wherein Ring A, X3, R1, R2, R3, R4 and R6 are as herein defined, and their synthesis and use as protein kinase inhibitors and interactions thereof.

DIARYLSULFONES AS 5-HT2A ANTAGONISTS

Compounds of formula (I) are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Suzuki couplings with phthalimidines - An efficient route to staurosporinone analogs

Staurosporinone analogs have been prepared by an efficient process. The key step is a palladium mediated Suzuki coupling between a bromophthalimidine and an aromatic boronic acid.