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2-Acetamido-5-chlorothiazole, an organochlorine compound with the molecular formula C6H6ClN3OS, features a thiazole ring and an acetamido group. It is a white to light yellow crystalline solid that is soluble in organic solvents. 2-ACETAMIDO-5-CHLOROTHIAZOLE is utilized in various chemical syntheses and exhibits antimicrobial and antifungal properties, making it a versatile intermediate in the production of pharmaceuticals, agrochemicals, dyes, pigments, and other organic compounds.

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  • 20256-39-7 Structure
  • Basic information

    1. Product Name: 2-ACETAMIDO-5-CHLOROTHIAZOLE
    2. Synonyms: 2-ACETAMIDO-5-CHLOROTHIAZOLE;2-Acetamido-5-chlorthiazol;2-Acetylamino-5-chlorothiazole;N-(5-chloro-1,3-thiazol-2-yl)acetamide
    3. CAS NO:20256-39-7
    4. Molecular Formula: C5H5ClN2OS
    5. Molecular Weight: 176.62
    6. EINECS: -0
    7. Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiazoles;ThiazolesHeterocyclic Building Blocks
    8. Mol File: 20256-39-7.mol
  • Chemical Properties

    1. Melting Point: 208-210°C
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.507g/cm3
    6. Refractive Index: 1.633
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. PKA: 9.03±0.50(Predicted)
    10. BRN: 120475
    11. CAS DataBase Reference: 2-ACETAMIDO-5-CHLOROTHIAZOLE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-ACETAMIDO-5-CHLOROTHIAZOLE(20256-39-7)
    13. EPA Substance Registry System: 2-ACETAMIDO-5-CHLOROTHIAZOLE(20256-39-7)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 36/37/38-22
    3. Safety Statements: 26-36-36/37
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 20256-39-7(Hazardous Substances Data)

20256-39-7 Usage

Uses

Used in Pharmaceutical Industry:
2-Acetamido-5-chlorothiazole is used as a key intermediate in the synthesis of various pharmaceuticals for its antimicrobial and antifungal properties. It contributes to the development of drugs that target a wide range of microbial infections, enhancing the effectiveness of treatments and combating drug resistance.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Acetamido-5-chlorothiazole serves as an essential component in the production of pesticides and fungicides. Its antimicrobial properties help protect crops from diseases and pests, ensuring higher yields and better crop quality.
Used in Dye and Pigment Industry:
2-Acetamido-5-chlorothiazole is used as an intermediate in the synthesis of dyes and pigments, contributing to the creation of a diverse range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
As a versatile intermediate, 2-Acetamido-5-chlorothiazole is utilized in the synthesis of other organic compounds, expanding its applications across different industries and contributing to the development of new products and materials.
It is crucial to handle 2-Acetamido-5-chlorothiazole with care and follow proper safety precautions during its use to ensure the safety of both individuals and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 20256-39-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,5 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 20256-39:
(7*2)+(6*0)+(5*2)+(4*5)+(3*6)+(2*3)+(1*9)=77
77 % 10 = 7
So 20256-39-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H5ClN2OS/c1-3(9)8-5-7-2-4(6)10-5/h2H,1H3,(H,7,8,9)

20256-39-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Alfa Aesar

  • (L17151)  2-Acetamido-5-chlorothiazole, 97%   

  • 20256-39-7

  • 1g

  • 190.0CNY

  • Detail
  • Alfa Aesar

  • (L17151)  2-Acetamido-5-chlorothiazole, 97%   

  • 20256-39-7

  • 5g

  • 642.0CNY

  • Detail
  • Aldrich

  • (673129)  2-Acetamido-5-chlorothiazole  96%

  • 20256-39-7

  • 673129-10G

  • 1,007.37CNY

  • Detail

20256-39-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(5-chloro-1,3-thiazol-2-yl)acetamide

1.2 Other means of identification

Product number -
Other names 2-acetylamino-5-chlorothiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20256-39-7 SDS

20256-39-7Upstream product

20256-39-7Relevant articles and documents

Oxidative Photochlorination of Electron-Rich Arenes via in situ Bromination

Düsel, Simon Josef Siegfried,K?nig, Burkhard

supporting information, p. 1491 - 1495 (2019/04/30)

Electron-rich arenes are oxidatively photochlorinated in the presence of catalytic amounts of bromide ions, visible light, and 4CzIPN as organic photoredox catalyst. The substrates are brominated in situ in a first photoredox-catalyzed oxidation step, followed by a photocatalyzed ipso-chlorination, yielding the target compounds in high ortho/para regioselectivity. Dioxygen serves as a green and convenient terminal oxidant. The use of aqueous hydrochloric acid as the chloride source reduces the amount of saline by-products.

CFBSA: a novel and practical chlorinating reagent

Lu, Zehai,Li, Qingwei,Tang, Minghua,Jiang, Panpan,Zheng, Hao,Yang, Xianjin

supporting information, p. 14852 - 14855 (2015/10/06)

A structurally simple, highly reactive chlorinating reagent, N-chloro-N-fluorobenzenesulfonylamine (CFBSA), was conveniently prepared from inexpensive Chloramine B in high yield. A wide range of substrates were chlorinated with it to obtain products in good to high yields and appropriate selectivity.

Discovery of FR115092 : A novel antinephritic agent

Ogino, Takashi,Tsuji, Kiyoshi,Tojo, Takashi,Igari, Norihiro,Seki, Nobuo,Sudo, Yu,Manda, Toshitaka,Nishigaki, Fusako,Matsuo, Masaaki

, p. 75 - 80 (2007/10/03)

A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092,26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.

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