20561-09-5Relevant articles and documents
Synthetic method of alicyclic diester
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Paragraph 0032; 0034; 0043; 0045, (2018/11/03)
The invention discloses a synthetic method of alicyclic diester. The synthetic method comprises the following steps: enabling diacid comprising a multi-carbon lipid chain end group or diester containing a multi-carbon lipid chain end group to react with a first halogenation reagent, after the reaction is completed, adding a second halogenation reagent into a reaction product, after the reaction iscompleted, re-esterifying, and obtaining the di-ester of di-halogenation; adding the di-ester of the di-halogenation into an organic solvent, adding alkali to perform the reaction, after the reactionis completed, adding acid to perform the neutralization, and obtaining annular di-ester; and performing the reduction reaction for the annular di-ester, and obtaining the alicyclic diester. By adopting the synthetic method, a novel reaction path is developed, and the direct-chain end-group diacid or diester is used as a raw material to prepare the alicyclic diester by virtue of bromination reaction, ring-closing reaction and the reduction reaction. The initial raw material is low in cost, the process is simple, the reaction condition requirement is low, the safety is good, the product yield and purity are high, and the mass production is easy to realize. Moreover, the diester of a three-membered ring to an eighteen-membered ring can be prepared by utilizing the synthetic method of the invention.
An efficient and improved process for the scale-up preparation of cis-cyclopropanediamine dihydrochloride
Wang, Fan,Xu, Xiao-Ying,Wang, Fei-Ying,Peng, Lin,Zhang, Yong,Wang, Liang-Liang,Wang, Li-Xin
, p. 741 - 744 (2016/03/25)
An effective and improved process for the preparation of cis-cyclopro panediamine dihydrochloride was developed in a 100 g scale. The key step in the process is the preparation of ciscyclopropane-1, 2-dicarboxylic acid from a mixture of cis- and transisomers by the formation of cyclic acidic anhydride. The whole process and all of the procedures are economical, industrially reliable and easily scaled up.
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors
Simpkins, Ligaya M.,Bolton, Scott,Pi, Zulan,Sutton, James C.,Kwon, Chet,Zhao, Guohua,Magnin, David R.,Augeri, David J.,Gungor, Timur,Rotella, David P.,Sun, Zhong,Liu, Yajun,Slusarchyk, William S.,Marcinkeviciene, Jovita,Robertson, James G.,Wang, Aiying,Robl, Jeffrey A.,Atwal, Karnail S.,Zahler, Robert L.,Parker, Rex A.,Kirby, Mark S.,Hamann, Lawrence G.
, p. 6476 - 6480 (2008/09/16)
The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold.
Herbicidal tricyclic heterocycles
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, (2008/06/13)
Compounds of Formula I having herbicidal utility are disclosed: STR1 wherein Q, R1, R2, V, m and p are defined in the text, including compositions containing such compounds, and a method for controlling weeds employing such compounds.
Facile Synthesis of Polysubstituted Cyclopropanes in a Two-Phase Solid-Liquid System
Chaoguo, Yan,Qiangzhi, Kong,Wenxing, Lu,Jitao, Wu
, p. 1651 - 1653 (2007/10/02)
The Michael addition of α-chloro esters to α,β-unsaturated systems was catalyzed by phase transfer catalyst, and the some polysubstituted cyclopropanes were facilly synthesized.
Purine derivatives
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, (2008/06/13)
Purines and pyrimidines having a fused cyclopropane ring in the side chain and the heterocyclic isosteres of said purines and pyrimidines have antiviral activity, especially against viruses of the herpes class.
Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)2
Kobayashi, Yoshiro,Taguchi, Takeo,Morikawa, Tsutomu,Tokuno, Etsuko,Sekiguchi, Shoh
, p. 262 - 267 (2007/10/02)
The oxidative coupling of ketone enolates and trimethylsilyl enol ethers by means of cupric trifluoromethanesulfonate is described in detail. 1,4-Diketones were effectively prepared by treating lithium enolates with Cu(OTf)2 in i-PrCN. 1,3-Cyclopentanedione derivatives were synthesized through intramolecular coupling of 2,4-pentanedione derivatives.Treatment of trimethylsilyl enol ethers with Cu(OTf)2 in i-PrCN also afforded the corresponding coupling products. Keywords---Oxidative coupling; cupric trifluoromethanesulfonate; 1,4-diketones; 1,3-cyclopentanediones; trimethylsilyl enol ether
Molybdenum Hexacarbonyl Catalyzed Cyclopropanation of α,β-Unsaturated Esters and Nitriles with Diazocarbonyl Compounds
Doyle, Michael P.,Davidson, James G.
, p. 1538 - 1539 (2007/10/02)
Molybdenum hexacarbonyl, when employed in catalytic amounts, effectively promotes cyclopropanation of acrylonitrile, methacrylonitrile, and ethyl acrylate by ethyl diazoacetate and α-diazoacetophenone; the intermediacy of molybdenum carbene species in the formation of cyclopropane derivatives is suggested.
