20921-00-0

Basic information

• Product Name: 6-BroMochroMan-2-one
• Synonyms: 6-BroMochroMan-2-one
• CAS NO: 20921-00-0
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.05468
• Mol File: 20921-00-0.mol

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 329.5°Cat760mmHg
• Flash Point: 153.1°C
• Appearance: /
• Density: 1.621g/cm³
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 6-BroMochroMan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMochroMan-2-one(20921-00-0)
• EPA Substance Registry System: 6-BroMochroMan-2-one(20921-00-0)

Safety Data

• Hazardous Substances Data: 20921-00-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
6-Bromochroman-2-one is used as a key intermediate in the synthesis of various pharmaceuticals for its unique chemical properties and reactivity, contributing to the development of novel therapeutic agents.
Used in Agrochemical Synthesis:
In the agrochemical industry, 6-bromochroman-2-one is employed as a building block in the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Research and Development:
6-Bromochroman-2-one serves as a valuable compound in the research and development of new chemical entities, facilitating the discovery of innovative applications and compounds with improved properties.
Used in Antioxidant and Anti-Inflammatory Studies:
6-Bromochroman-2-one is utilized in pharmacological research as a subject of study for its potential antioxidant and anti-inflammatory properties, which could lead to the development of new treatments for various diseases and conditions.

Upstream product

• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 34598-49-7 5-Bromo-1-indanone 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 92569-86-3 5-bromo-2-hydroxycinnamaldehyde 
• 495-78-3 3-(2-hydroxyphenyl)propionic acid 
• 19063-55-9 6-bromo-2H-chromen-2-one 
• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 82547-30-6 3-(5-bromo-2-methoxyphenyl) propanoic acid 
• 749878-59-9 3-(5-bromo-2-hydroxy-phenyl)-propionic acid 

Downstream Products

• 20921-12-4 β-(2-Hydroxy-5-brom-phenyl)-propionsaeure-ethylester 
• 33567-65-6 4-bromo-2-(3-hydroxypropyl)phenol 
• 893426-64-7 6-(1-hydroxy-2-(4-pentyl-2-fluorophenyl)ethyl)-3,4-dihydrocoumarin 
• 1360054-35-8 (E)-4-bromo-2-(5-hydroxypent-3-enyl)phenol 
• 1360054-11-0 (E)-5-(5-bromo-2-hydroxyphenyl)pent-2-enyl 2,2,2-trichloroacetimidate 
• 1360054-22-3 (E)-5-(5-bromo-2-hydroxyphenyl)pent-2-enyl acetate 
• 61370-75-0 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde 
• 1383542-02-6 C₂₁H₁₇ClF₂N₂O₂ 
• 33538-85-1 5-Brom-2-methoxyhydrozimtaldehyd 
• 33538-79-3 5-Brom-2-methoxyhydrozimtalkohol 
• 128652-04-0 methyl(5-hydroxy-3-trimethylsilylethynylphenyl)propionate 
• 131194-48-4 5-(2,2-Dibenzyl-chroman-6-ylmethyl)-thiazolidine-2,4-dione 
• 131194-72-4 2,2-dibenzyl-6-bromo-3,4-dihydro-2H-1-benzopyran 

Relevant articles and documents

Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material

A four-step synthesis of the indanone core of belzutifan (MK-6482) is described. This route starts from the commodity raw material dihydrocoumarin and was successfully demonstrated on a large scale to produce indanone 11 in the synthesis of belzutifan, an FDA-approved first-in-class therapy for the treatment of patients with certain types of Von Hippel-Lindau disease-associated tumors.

CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES

Disclosed are novel chromane-substituted tetracyclic compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, A', R2 R3, R4 and R5 are as defined in the description. Also disclosed are compositions comprising a chromane-substituted tetracyclic compound, and methods of using the chromane-substituted tetracyclic compounds for treating or preventing HCV infection in a patient.

Enantioselective Synthesis of Chromenes via a Palladium-Catalyzed Asymmetric Redox-Relay Heck Reaction

A palladium-catalyzed asymmetric redox-relay Heck reaction of 4H-chromenes and arylboronic acids has been successfully developed. The reaction proceeded in moderate to good yields with good to high enantioselectivities. The resulting product is an advanced intermediate of bio-active compound BW683C.

SYNTHESIS OF TERPHENYL COMPOUNDS

The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I or intermediates thereof.

NOVEL 2-AMINO-PYRIDINE AND 2-AMINO-PYRIMIDINE DERIVATIVES AND MEDICINAL USE THEREOF

Provided is a compound superior in an autotaxin inhibitory action and the like, effective as a prophylactic or therapeutic drug for diseases involving ATX. The present invention relates to a compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], which has a superior autotaxin inhibitory action and is useful as a prophylactic or therapeutic drug for diseases involving ATX.

Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants

The discovery of potent and pan-genotypic HCV NS5A inhibitors faces many challenges including the significant diversity among genotypes, substantial potency shift conferred on some key resistance-associated variants, inconsistent SARs between different genotypes and mutants, and the lacking of models of inhibitor/protein complexes for rational inhibitor design. As part of ongoing efforts on HCV NS5A inhibition at Merck, we now describe the discovery of a novel series of chromane containing NS5A inhibitors. SAR studies around the "Z" group of the tetracyclic indole scaffold explored fused bicyclic rings as alternates to the phenyl group of elbasvir (1, MK-8742) and identified novel chromane and 2,3-dihydrobenzofuran derivatives as "Z" group replacements offered good potency across all genotypes. This effort, incorporating the C-1 fluoro substitution at the tetracyclic indole core, led to the discovery of a new series of NS5A inhibitors, such as compounds 14 and 25-28, with significantly improved potency against resistance-associated variants, such as GT2b, GT1a Y93H, and GT1a L31V. Compound 14 also showed reasonable PK exposures in preclinical species (rat and dog).

Enzymatic Baeyer-Villiger oxidation of Benzo-Fused ketones: Formation of regiocomplementary lactones

Baeyer-Villiger monooxygenases (BVMOs) are enzymes that are known to catalyse the Baeyer-Villiger oxidation of ketones in aqueous media using O2 as oxidant. Herein, we describe the oxidation of a set of diverse benzo-fused ketones by three different BVMOs

COMPOUNDS, COMPOSITIONS AND METHODS

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Titanocene-Catalyzed Reduction of Lactones to Lactols

A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.