61370-75-0

Basic information

• Product Name: 2,2-DIMETHYLCHROMANE-6-CARBALDEHYDE
• Synonyms: BUTTPARK 93\04-17;2,2-DIMETHYLCHROMANE-2-CARBALDEHYDE;2,2-DIMETHYLCHROMANE-6-CARBALDEHYDE;2,2-DIMETHYLCHROMANE-6-CARBOXALDEHYDE;AKOS MSC-0776;2,2-Dimethylchromane-2-carbaldehyde, 90%+;2,2-Dimethylchromane-6-carbaldehyde, tech;2,2-DIMETHYLCHROMANE-2-CARBALDEHYDE: TECH.
• CAS NO: 61370-75-0
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.24
• Mol File: 61370-75-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 97-98℃
• Boiling Point: 110-114°C 2mm
• Flash Point: 131.5°C
• Appearance: /
• Density: 1.072±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.00112mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2-DIMETHYLCHROMANE-6-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYLCHROMANE-6-CARBALDEHYDE(61370-75-0)
• EPA Substance Registry System: 2,2-DIMETHYLCHROMANE-6-CARBALDEHYDE(61370-75-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 61370-75-0(Hazardous Substances Data)

Usage

General Description

2,2-Dimethylchromane-6-carbaldehyde, also referred to by its CAS number 23460-09-7, is a chemical compound that falls under the category of chromanes. Chromanes are a class of organic compounds that contain a benzene ring fused to a heterocyclic oxygen-containing ring. The structural specificity of 2,2-Dimethylchromane-6-carbaldehyde is denoted by the presence of two methyl groups at the second carbon atom and a carbaldehyde functional group at the sixth carbon. This chemical is largely used in the manufacture of other products, and is not typically found naturally occurring in the environment. Information about its physical properties, toxicity, or potential uses in commercial or industrial applications may vary and can depend on purity grade or specific composition.

InChI:InChI=1/C12H14O2/c1-12(2)6-5-10-7-9(8-13)3-4-11(10)14-12/h3-4,7-8H,5-6H2,1-2H3

Upstream product

• 23446-57-3 2,2,6-trimethyl-3,4-dihydro-2H-chromene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 78-79-5 isoprene 
• 28090-12-2 4-(3-methyl-but-2-enyloxy)-benzaldehyde 
• 870-63-3 prenyl bromide 
• 54730-30-2 4-hydroxy-3-C-prenylbenzaldehyde 
• 20921-00-0 6-bromo-3,4-dihydro-2H-1-benzopyran-2-one 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 74021-58-2 4-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde 
• 204503-25-3 1-bromo-4-((3-methylbut-2-en-1-yl)oxy)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 174894-80-5 6-bromo-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran 
• 106-44-5 p-cresol 
• 4167-73-1 4-(2-hydroxyphenyl)-2-methyl-2-butanol 

Downstream Products

• 12772-83-7 3-[2,2-dimethyl-3,4-dihydro-(2H)-benzopyran-6-yl]-2E-propenoic acid 
• 61370-82-9 (2,2-dimethylchroman-6-yl)methanol 
• 2039-47-6 2,2-dimethylchroman-6-carboxylic acid 
• 69964-40-5 6-formyl-2,2-dimethyl-2H-chromene 
• 95604-08-3 2,2-Dimethyl-chroman-6-carbonyl bromide 
• 1608121-24-9 (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one 
• 1608121-21-6 (Z)-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one 
• 1383719-84-3 C₂₈H₃₆N₂O₄ 
• 1253582-74-9 4-(1-(2,2-dimethylchroman-6-yl)-3-phenylprop-2-ynyl)morpholine 
• 1253582-75-0 1-(1-(2,2-dimethylchroman-6-yl)-3-phenylprop-2-ynyl)piperidine 
• 71822-00-9 <1-hydroxyethyl>-2,2-dimethylchromene 

Relevant articles and documents

Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives

In an effort to develop potent anti-inflammatory agents, a series of novel chroman derivatives including acyclic amidochromans, chromanyl esters and chromanyl acrylates have been designed, synthesized and fully characterized. These chroman analogues were screened for their anti-inflammatory activities through inhibition of the TNF-α-induced ICAM-1 expression on human endothelial cells. A structure-activity relationship was also established and it has been found that in the case of carboxy chromans and amidochromans, the chain length of the amide moiety, branching of the side chain and the presence of the substituents on the phenyl ring have significant effects on their inhibitory activities, while in chromanyl acrylates, the number of methoxy groups, their relative positions on the phenyl ring, and presence of functional groups in the α,β-unsaturated ester moiety played a critical role on their activities. Compound 14 (N-hexyl-7-hydroxy-2,2-dimethylchromane-6-carboxamide) was found to be the most potent compound in inhibiting the TNF-α-induced expression of ICAM-1 on endothelial cells. This journal is

CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES

Disclosed are novel chromane-substituted tetracyclic compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, A', R2 R3, R4 and R5 are as defined in the description. Also disclosed are compositions comprising a chromane-substituted tetracyclic compound, and methods of using the chromane-substituted tetracyclic compounds for treating or preventing HCV infection in a patient.

Synthetic method for rubrolide compounds E, F, R, S and their derivatives

Rubrolide F (compound 1f), R (compound 1r), and S (compound 1s), which are biological important natural butenolides, 7andPrime;,8andPrime;-didihydro derivatives (compound 1sa) thereof, 3andPrime; -bromorubrolide (compound 1fa), rubrolide E (compound 1e) and di-O-methyl derivatives thereof (compound 1ea) can be industrially obtained and are effectively synthesized with the overall yield of 14-48.5% from low-priced precursors. The rubrolide compounds can be synthesized through a Knoevenagel condensation reaction after a Wittig-Horner reaction and SeO_2-induced tandem allylic hydroxylation/intramolecular cyclization for preparing butenolide rings and a rubrolide cores structure.COPYRIGHT KIPO 2017