210346-49-9Relevant articles and documents
INHINITORS OF GLI1 AS THERAPEUTIC AGENTS
-
Paragraph 0155; 0157, (2020/06/10)
This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to glioma- associated oncogene (Gli) expression. More particularly, this disclosure relate
5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE
-
Page/Page column 99, (2017/02/28)
Provided in some embodiments are compounds of Formula A, as defined herein, that modulate the activity of 5-HT2C receptor. Also provided in some embodiments are methods, such as, for weight management, inducing satiety, and decreasing food intake, and for
NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF
-
Paragraph 00159, (2017/07/06)
Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.
CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES
-
Paragraph 203-205, (2017/09/15)
The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.
Development of a new family of chiral auxiliaries
Gelat, Fabien,Richard, Vincent,Berger, Olivier,Montchamp, Jean-Luc
supporting information, p. 1819 - 1821 (2015/04/27)
A new family of chiral auxiliaries designed on a conformationally restricted version of (-)-8-phenylmenthol has been developed. Both enantiomers are available from an inexpensive synthesis conducted on multigram scale. A first application has showed compa
Photoassisted synthesis of enantiopure alkaloid mimics possessing unprecedented polyheterocyclic cores
Kumar, N.N. Bhuvan,Mukhina, Olga A.,Kutateladze, Andrei G.
supporting information, p. 9608 - 9611 (2013/07/26)
Enantiopure alkaloid mimics are synthesized via high yielding intramolecular cycloadditions of photogenerated azaxylylenes tethered to pyrroles, with further growth of molecular complexity via post-photochemical transformations of primary photoproducts. This expeditious access to structurally unprecedented polyheterocyclic cores is being developed in the context of diversity-oriented synthesis, as the modular design allows for rapid "pre-assembly" of diverse photoprecursors from simple building blocks/diversity inputs.
Rapid photoassisted access to N,O,S-polyheterocycles with benzoazocine and hydroquinoline cores: Intramolecular cycloadditions of photogenerated azaxylylenes
Mukhina, Olga A.,Bhuvan Kumar,Arisco, Teresa M.,Valiulin, Roman A.,Metzel, Greg A.,Kutateladze, Andrei G.
supporting information; experimental part, p. 9423 - 9428 (2011/11/06)
Ring the changes: A new photoassisted approach to give conformationally constrained N,O,S-polyheterocyclic scaffolds of unprecedented topologies was achieved by intramolecular [4+4] and [4+2] cycloadditions of photogenerated o-azaxylylenes (23 examples; see scheme). The precursors can be readily assembled by simple and high-yielding reactions, thus making this a powerful synthetic method amenable to high-throughput diversity-oriented synthesis.
Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof
-
Page/Page column 30-31, (2009/10/06)
The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands
Caldwell, John P.,Matasi, Julius J.,Zhang, Hongtao,Fawzi, Ahmad,Tulshian, Deen B.
, p. 2281 - 2284 (2007/10/03)
A series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.
N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES
-
Page/Page column 41, (2008/06/13)
Novel N-phenyl-1,1,1-trifluoromethanesulfonamide compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo and ex vivo.