211315-09-2

Basic information

• Product Name: 2-(4-Benzyloxy-phenyl)-propionitrile
• Synonyms: 2-(4-Benzyloxy-phenyl)-propionitrile
• CAS NO: 211315-09-2
• Molecular Formula: C16H15NO
• Molecular Weight: 237.2964
• EINECS: -0
• Mol File: 211315-09-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Benzyloxy-phenyl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Benzyloxy-phenyl)-propionitrile(211315-09-2)
• EPA Substance Registry System: 2-(4-Benzyloxy-phenyl)-propionitrile(211315-09-2)

Safety Data

• Hazardous Substances Data: 211315-09-2(Hazardous Substances Data)

Usage

Structure

A derivative of propionitrile with a benzyl ether group attached to the 4-position of the phenyl ring.

Usage

Organic synthesis as a building block for the production of various pharmaceuticals and other organic compounds.

Application

Utilized in the development of new materials and chemical processes.

Reactivity

The presence of the propionitrile group imparts reactivity that is useful for a variety of chemical reactions and transformations.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 56441-91-9 1-(benzyloxy)-4-ethylbenzene 
• 54696-05-8 4'-benzyloxy-acetophenone 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 14191-95-8 4-cyanomethylphenol 
• 100-39-0 benzyl bromide 
• 36438-63-8 1-(4-[benzyloxy]phenyl)ethan-1-ol 
• 124-38-9 carbon dioxide 
• 838-96-0 2-[4-(benzyloxy)phenyl]acetonitrile 

Relevant articles and documents

α-Methylation of 2-Arylacetonitrile by a Trimethylamine-Borane/CO2 System

A highly selective monomethylation of 2-arylacetonitrile using CO2 is described. The utilization of trimethylamine-borane facilitates the six-electron reduction of CO2. This reaction is the first selective six-electron reductive functionalization of CO2 faciliated by C(sp3)-H bonds. A variety of 2-arylpropionitrile was obtained in good yields. The reaction could also be applied at the gram scale.

Facile preparation of α-aryl nitriles by direct cyanation of alcohols with TMSCN under the catalysis of InX3

(Chemical Equation Presented) A convenient and efficient synthesis of α-aryl nitrites was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.

Heterocyclyl sulphonamide derivatives

The present invention relates to the potentiation of glutamate receptor function using certain heterocyclyl sulphonamide derivatives. It also relates to novel heterocyclyl sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.

Sulphonamide derivatives

Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formulaR1—L—NHSO2R2??Iin whichR1 represents an unsubstituted or substituted aromatic or heteroaromatic group;R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; andL represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring;and pharmaceutically acceptable salts thereof.Also disclosed are compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.

Sulphonamide derivatives

The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.

Benzylic Cyanation via Oxidation and Simultaneous Nucleophilic Substitution

Use of dichlorodicyano benzoquinone and trimethylsilyl cyanide in suitable solvent permits the direct and ready transformation of benzylic C-H bonds to C-CN bonds with high yield and selectivity via oxidation and simultaneous nucleophilic substitution.